10 Yeat Collection is the best gift ever!
"The products are amazing"
Limited Time
Enjoy 48% SAVINGS compared to purchasing individually
+ GIFT: NEW 7X Calming Complex
+ FREE 100% Silk Pillowcase
TAKE AN ADDITIONAL
15 % OFF select Holiday Collections
With this offer, the collection is $508.30. Discount applied automatically in the cart.



















2025 Science of Skin Award, Most Innovative Skincare Range, Top Medical Skincare Lines, Most Innovative 2024 Fast Company, Star Products Award, Eye Product of the Year, Best Neck Cream, Best-In-Class Body, Best Brightening Mask, Non-Surgical Innovator of the Year, Beauty Choice Award, Best Eye Cream For Dark Circles, The Secret to a Firmer Neck Award, Best Nail Serum, Star Products Award, Editor's Pick, Best Age-Defying Lip Serum.
The 10 Year Anniversary Collection: 10 Years. 11 Innovative Products. One Complete Set.
Celebrate a decade of DefenAge with the 10 Year Anniversary Collection— a complete 11-product set featuring our most advanced, award-winning formulas in their largest sizes. Powered by our patented Age-Repair Defensins®, this exclusive collection showcases a decade of skincare innovation. From our hydrating cleanser to our cutting-edge serum, this collection offers targeted formulas for skin, lips, body, and hair. Every product reflects a chapter in our journey to redefine how we age, empowering you to look and feel your best, at every stage of life.
For limited time, this season, your 10 Year Collection also includes two exclusive gifts: our 100% Silk Pillowcase and NEW! 7X Calming Complex!
Available for a limited time and while supplies last.
The 10 Year Anniversary Collection is presented in its largest sizes for exceptional value and includes:
All products in this collection are presented in DefenAge’s signature gift box.
Made in the U.S.A.
Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with clean towel. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream and 6-Week Perfection Neck Cream).
Suitable for all skin types.
Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
After cleansing, while skin is still moist from rinsing, pump a drop of cream onto applicator. Lightly dab three dots of cream above and below each eye. Using applicator, massage cream around eyes. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.
Please visit the 12-Factor Revitalizing Lip Enhancer page for the usage directions for this innovative product ►
Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream and 6-Week Perfection Neck Cream).
Not recommended for acne, extremely sensitive or abraded skin.
Apply once or twice daily after showering or bathing. Smooth and lightly massage the cream from ankles to waist, then hands, arms, and shoulders, followed by rest of the body. Apply 8-in-1 BioSerum on elbows, knees, and other challenging areas to maximize results.
Suitable for all skin types.
Please visit the 360-Rejuvenation Nail Root Serum page for the usage directions for this innovative product ►
Please visit the 150K Hair Follicle Serum page for the usage directions for this innovative product ►
DefenAge is proven in more than 30 clinical studies. All DefenAge formulas are dermatologist tested. 1-Step Multi-Cleanse, 3D Eye Radiance Cream, and 8-in-1 BioSerum are also ophthalmologist tested.
Multi-center placebo-controlled double-blind clinical study shows that DefenAge “globally improves the visual appearance of aging skin” and “offers most of the advantages of time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin.”
Journal of Drugs in Dermatology 2018, 17(4): p. 426-441Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD
Learn More ►
Please visit the 360-Rejuvenation Nail Root Serum page to review clinical data relating to this innovative product ►
Please visit the 150K Hair Follicle Serum page to review clinical data relating to this innovative product ►
Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.
Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.
Liposome Encapsulated (Cream) | Low Molecular Weight (Serum)
Promotes hydration and improves texture for remarkably smooth and even skin.
This formula is infused with a powerful and concentrated composition of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.
The powerful blend of natural extracts balances the skin’s barrier, saves the skin’s natural moisture, and promotes the levels of Natural Moisturization Factors (NMFs).
Energizes skin hydration. Prevents moisture loss while restoring visible skin’s suppleness and flexibility. Fights skin damage and free radicals.
Helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. Hydrates the skin from within. Proven humectant.
Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.
This bundle contains eight of DefenAge’s top products; all of them are formulated based on the enhanced clean beauty standards. Find more information about our standards and why we raised the bar for skincare safety requirements on our Clean Beauty page.
The bottles, tubes, and boxes are fully recyclable, please recycle.
Not tested on animals.
The detailed ingredient lists can be reviewed on the individual product pages:
For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.
Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources.
This product is qualified for the Money Back Guarantee.
In case of a refund, all products in this bundle should be returned.
Return Policy ►
[ $1,154 value ]
Limited Time
Enjoy 48% SAVINGS compared to purchasing individually
+ GIFT: NEW 7X Calming Complex
+ FREE 100% Silk Pillowcase
TAKE AN ADDITIONAL
15 % OFF select Holiday Collections
With this offer, the collection is $508.30. Discount applied automatically in the cart.