Skincare for All Skin Tones, Learn More
Morning & Night Routine + FREE Full-Size Exfoliating Masque. Shop Now!
Unlock Youthful Skin: DefenAge's Day & Night Skincare Revolution!
Unlock Winter's Secret with our 8-in-1 BioSerum
Skincare for All Skin Tones, Learn More
Morning & Night Routine + FREE Full-Size Exfoliator. Shop Now!
Unlock Youthful Skin: DefenAge's Day & Night Skincare Revolution!
Unlock Winter's Secret with our 8-in-1 BioSerum

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

This product is covered by U.S. Patent No. 11,491,096.


Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

This product is covered by U.S. Patent No. 11,491,096.

/ $198.00 with free account /

Innovator Award

The 8-in-1 BioSerum is DefenAge's iconic bestseller. This patented technology, remarkably smart bio serum formula seems to understand your skin’s needs better than your DNA. Designed to activate, orchestrate, and energize the skin, this biologically advanced, anti-aging, and cream-like serum concentrate provides an unprecedented concentration of defensin molecules contained in the Age-Repair Defensin® Complex. Dermatologists and aesthetic professionals name defensins as a perfect retinol alternative and the 8-in-1 BioSerum as a retinol or bakuchiol serum replacement. The best part? Results are equal to eight separate serums. Get your best skin ever with 8-in-1 BioSerum.

The 8-in-1 BioSerum is perfect as a stand alone skincare product. The 8-in-1 BioSerum is also well known as a "treatment multiplier," dermatologists recommend the 8-in-1 BioSerum for pre- and post- aesthetic procedures to amplify the results of microneedling, RF-microneedling, fractional and ablative laser, and Sofwave. Find more about expected results when you add the 8-in-1 BioSerum to your treatment at the Clinical Studies tab.

Read expert opinions here.



How Our Bio Serum Works


The DefenAge 8-in-1 BioSerum works by improving the overall health and appearance of the skin. It helps


  • •  Rejuvenates smoothness. Improves overall visible skin health and quality.
  • •  Minimizes the look of fine lines, wrinkles, pores, and skin pigmentation and discolorations.
  • •  Promotes radiance and revives the skin’s natural moisture for an ultimate glow.
  • •  Brightens the overall skin tone and clarity and enhances skin luminosity.
  • •  Renews the feeling of skin firmness, elasticity, and texture.
  • •  Helps improve the appearance of skin redness.
  • •  Promotes the skin barrier and skin immunity.



Why 8-in-1 BioSerum Is Different


Our bio serum is an excellent retinol and bakuchiol serum alternative. We’ve combined advanced, targeted treatment with established and validated science to bring you a skin care product that is unlike any other on the market. Here’s what makes 8-in-1 BioSerum different.


  • •  Contains five times more defensin molecules than any other formula.
  • •  Light-weight application; “you don't feel it when you're wearing it”.
  • •  Effective and safe for the entire face, including the delicate skin around the eyes and lips, and the neck and décolleté.
  • •  High-performing on crepey thin skin on the neck and arms.
  • •  Fast-acting anti-aging — first results are seen within a few weeks.
  • •  Perfect as a daily skin care product for both men and women.
  • •  Effective for all stages of skin aging, including for people above 70.
  • •  Non-irritating and gentle on sensitive skin, unlike retinol.
  • •  Tolerated by all skin types, including those with rosacea and melasma.
  • •  Highly effective for pre- and post- aesthetic procedures to achieve the optimal outcomes, including microneedling and fractional and resurfacing laser treatments. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
  • •  Effective in preparing skin before fillers — start using four to six weeks before procedures.
  • •  DefenAge's most “likable” product with the most impressive consumer feedback.


Made in the U.S.A.



Add These Moisturizers to Your BioSerum Routine:




Ten Specific Ways Leading Dermatologists Recommend Using the 8-in-1 BioSerum:


  1. For daily use. It’s lightweight. “You can’t even feel it when you’re wearing it.” Dermatologist Vivian Bucay, MD


  1. For sensitive skin. It delivers anti-aging results but it’s “not irritating like a retinol or acids.” Dermatologist Anne Chapas, MD


  1. For older age. Even old skin has young dormant cells that can be turned on by defensins. “We saw a marked difference at 2 months” in a 73-year-old patient. Dermatologist Angela Bowers, MD


  1. For better skin quality, including firmer skin, fewer fine lines, more luminosity and clarity, and a reduced appearance of pores. Dermatologist Anne Chapas, MD


  1. After microneedling, patients are “less likely to break out with acne post treatment.” Dermatologist Vivian Bucay, MD


  1. “4 to 6 weeks before having filler procedures” to prep the skin and enhance results. Dermatologist Kathleen Welsh, MD


  1. Before and after ablative skin treatments, which “primes skin to respond more quickly and robustly, healing faster.” Dermatologist Steven Swengel, MD


  1. To target specific areas, including around the eyes and lips. Dermatologist Angela Bowers, MD


  1. Beyond the face: on the neck and décolleté. Dermatologist Steven Swengel, MD


  1. For crepey thin skin on the neck and arms. Dermatologist Kathleen Welsh, MD


Dermatologists weigh in on DefenAge’s 8-in-1 BioSerum: Patient outcomes, optimal use. The Dermatology Digest (2021) January, p. 40-42.



How and Why You Should Add the 8-in-1 BioSerum to Your Skincare Regimen?


Dermatologists agree, if you do one nice thing for your skin this year - introduce it to defensin-molecules. Defensins can be incorporated into your existing skincare regimen and do not conflict or compete with other skincare. Whether it’s CHANEL or Clinique, incorporating DefenAge + Defensins can actually enhance the skincare you already know and love.


Consumer survey says that 93% of consumers who use CHANEL

skincare also like the results they see with DefenAge!

/ Survey 2019, data on file /


“Why do CHANEL users like DefenAge? – this is simple – DefenAge’s defensins multiply the effect of other skincare. …Ironically, DefenAge skin care has no competition on the skincare market because it enhances any other skin care brands. Much like laser treatments and microneedling, the topical application of defensins causes our body to message ‘preserved,’ healthy cells to create visibly new skin. I recommend the BioSerum to my patients to activate their “skin’s memory”, triggering skin to look younger, twice a day – in the morning and evening by applying just one drop of DefenAge BioSerum over the moisturizer of their choice,”

-Board-certified dermatologist Natalie M. Curcio, M.D., M.P.H.


Check with us, what other skincare than CHANEL can be combined with DefenAge's defensins for more glowing skin.  



Opinions and Stories


Healthy, Simple, and Safe Skincare Routines with Defensins from Supermodel Veronica Webb

by Veronica Webb, supermodel mom and influencer

Aging powerfully is as much about your attitude as it is about the skincare products you use. Veronica Webb, supermodel, mom, influencer, and beauty writer talks dermatologist recommended anti-aging clean beauty serums, moisturizers, and cleansers. Veronica shares her take simple safe and healthy confidence-boosting skincare routines that make a daily difference. Read more ...


How Effective Is Combining Products From Different Skincare Lines?

by Eliza Cabana, aesthetic and skin rejuvenation guru

Don’t want to give up your Chanel (or other) skincare product for something new? With DefenAge, you don’t have to! One expert explains how you can combine your favorite products with the DefenAge line to get all the benefits of both. Read more ...


The Secret to Effective 'Anti-Aging'

by Eliza Cabana, aesthetic and skin rejuvenation guru

Who doesn’t love a good anti-aging cream? But will it actually turn back the clock for your skin? One expert shares her perspective on the “anti-aging” misnomer as well as tips for what steps you can take to get the most out of your skincare routine. Read more...


Introduce Your Skin to the Benefits of DefenAge’s 8-in-1 BioSerum This Year

DefenAge’s 8-in-1 BioSerum may be lightweight, but it packs more Defensin molecules than any of DefenAge’s other products. Age-Repair Defensins wake up dormant cells to make brand-new, healthy cells. The result is skin that looks brighter, smoother, and firmer. If you don’t want to use retinol, try the dermatologist recommended skin care from DefenAge, including 8-in-1 BioSerum. Age-Repair Defensins are just as effective as retinol. Read more...


How to Get the Best Results From Your Anti-Aging Skin Care Products

The best anti aging skin care products will help your skin look brighter, smoother, plumper, and reduce the appearance of wrinkles. But if you want to truly maximize the product’s effectiveness, there are several things to keep in mind. Using skin care products that address signs of aging is a commitment, but it’s worth it when you start seeing results. Read more...


DefenAge’s Anti-Aging Serum: A Spring Skin Care Must-Have

The 8-in-1 BioSerum, anti-aging serum, from DefenAge is a best-selling product with the highest concentration of Age-Repair Defensins. Defensins are molecules that prompt dormant cells to make brand-new, healthy skin cells. DefenAge is the only brand to use Age-Repair Defensins, a proprietary ingredient. The result is new skin cells that look younger and healthier. DefenAge’s products don’t merely cover signs of visible aging.



8-in-1 BioSerum

8-in-1 BioSerum 

Daily: AM | PM

Place one pump of the 8-in-1 BioSerum Concept Anti-Aging Cream onto fingertips. Lightly massage, first around the eyes, then over the entire face. Use a second pump on the neck and décolleté. Always follow the one pump rule - one pump per area if you would like to use this product on the arms, elbows, and knees. Layer sunscreen on top of the bio serum in the morning or day time before leaving house. 

This product is suitable for all skin types.





For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 7 clinical studies.


The 8-in-1 BioSerum was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.

Additional ophthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.

The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.

All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.

We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile. Because of the exceptional results seen with the use of the 8-in-1 BioSerum and the unique mechanism of action of Defensin-molecules, the 8-in-1 BioSerum is commonly called "microneedling in a bottle."

Before and After

Before and After


Microneedling and RF-Microneedling: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Fractional laser: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Ablative laser: 7 days post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Safewave and other non-invasive procedures: Immediately post-procedure, apply Clinical Power Trio for 2-4 weeks.

Before and After

Before and After



Age-Repair Defensins® | 5X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone. The 8-in-1 BioSerum is named 'Best Niacinamide and Hyaluronic Acid Serum of 2024' by Good Housekeeping magazine.

Hyaluronic Acid | Low Molecular Weight

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excused from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.



The bottle, box and package components are fully recyclable, please recycle.

We do not test products on animals.


8-in-1 BioSerum | Concept Anti Aging Cream

Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Sea Whip Extract, Ergothioneine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Offinalis (Rosemary) Leaf Extract, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Albumin, L-Alanyl-L-Glutamine, Caprylic/Capric Triglyceride, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride.
Fragrance free.

This product does not contain retinol and should not be considered as a retinol serum.



Quality guaranteed ONLY when 8-in-1 BioSerum is sold by or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



8-in-1 BioSerum | Concept Anti Aging Cream (bio serum) is qualified for the Money Back Guarantee.
Return Policy ►


Why should the 8-in-1 BioSerum be layered last in a skincare routine?
The reason is because of a unique property of defensin molecules. Our bio serum contains DefenAge’s highest dose of defensins, which not only stimulate new skin, but also have shown to be effective in preventing water loss via the skin-surface’s natural “tight junction” mechanism. In other words, defensins “lock gaps” between surface cells; therefore water cannot go out, it is locked inside, but together with this – nothing goes in, meaning that if you apply any other creams or serums on top of the 8-in-1 BioSerum, their ingredients may not be absorbed. We recommend that all skin care products in your routine be layered before the 8-in-1 BioSerum, only makeup and sunscreen should be layered on top in the morning, and nothing should be layered at night; please review the dermatologist recommendations on night skincare routines on our How-To Page.
My skin is glowing right after a week of the use of 8-in-1 BioSerum, can I increase the number of pumps for even more results?
Please be patient, more is not better. More results will not show up just because of an overuse of the bio serum. Concentrations of ingredients are very well balanced in the formula, please just follow with the recommended dosage and do it regularly: morning and night – results will not disappoint. Use one pump of the 8-in-1 BioSerum on the face and one on the neck. We also recommend exfoliating the skin regularly to see results faster – removing old cells from skin’s surface will unveil beautiful new skin; DefenAge’s gentle solution for exfoliation is the 2-Minute Reveal Masque.
Do I need to use a Vitamin C serum together with the Defensin anti-aging serum?
DefenAge’s 8-in-1 BioSerum contains a fine blend of naturally powerful anti-oxidants. We do not restrict DefenAge users form the using vitamin C serum, although we believe that it is unnecessary.
Is it true that makeup will be applied easier on skin treated with 8-in-1 BioSerum?
This is true. Due to the high concentration of defensin molecules, the skin will become smoother after using 8-in-1 BioSerum, therefore makeup will be applied easier than usual. Some consumers even say, “I do not need foundation after I started using DefenAge's bioserum.”
Is 8-in-1 BioSerum good for acne prone skin?
Yes it is. The 8-in-1 BioSerum is safe for acne prone skin, our bio serum underwent multiple safety studies that returned an outstanding safety profile. Please be sure that you use the exact quantity of the product that we recommended, and do not exceed it: 1 pump of the bio serum for entire face and 1 pump on the neck.