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This product is covered by U.S. Patent No. 11,491,096.


This product is covered by U.S. Patent No. 11,491,096.


Innovator Award

Intense hydrating cream infused with Age-Repair Defensins®, multi-action barrier balancing ingredients and skin brightening skincare actives work together to regenerate and rejuvenate the appearance of skin. 


  • •  Innovative formula helps replenish and balance the skin's natural barrier.
  • •  Revives radiance and improves overall tone and texture for remarkably smooth, even skin.
  • •  With regular use, skin looks brighter and feels firmer.


Made in the U.S.A.




24/7 Barrier Balance Cream

STEP TWO - FACE| 24/7 Barrier Balance Cream

Daily: AM | PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. 
Suitable for all skin types.

Dermatologist tested. Clinically proven effective.



Age-Repair Defensins® | 1X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

Hyaluronic Acid | Liposome - Encapsulated

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


The same as all other DefenAge products, the 24/7 Barrier Balance Cream is formulated with clean skincare in mind. To learn more about DefenAge’s clean standards please visit our Clean Beauty page.


The bottle and box are fully recyclable, please recycle.

Not tested on animals.



24/7 Barrier Balance Cream

Water (Aqua), Carthamus Tinctorius (Safflower) Oleosomes, Butyrospermum Parkii (Shea) Butter, Macadamia Integrifolia Seed Oil, Niacinamide, Yeast Extract, Ammonium Acryloyldimethyltaurate/ VP Copolymer, Helianthus Annuus (Sunflower) Seed Oil, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Hyaluronic Acid, Ophiopogon Japonicus Root Extract, Hydrolyzed Candida Saitoana Extract, Sea Whip Extract, Lycium Chinense Fruit Extract, Vaccinium Angustifolium Fruit Extract, Vaccinium Marcrocarpon Fruit (Cranberry) Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Panthenol, Albumin, Tocopheryl Acetate, Ubiquinone, L-Alanyl-L-Glutamine, Leuconostoc/Radish Root Ferment Filtrate, Xanthan Gum, Phytic Acid, Polysorbate 20, Caprylic/Capric Triglyceride, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Potassium Sorbate, Sodium Chloride.
Fragrance free.


For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.



Quality guaranteed ONLY when sold by or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



This product is qualified for the Money Back Guarantee.
Return Policy ►


Why should STEP 2 creams be layered before the 8-in-1 BioSerum?
In addition to stimulating new skin, defensins have an extra beneficial action to "close gaps" between cells on the surface of our skin. It means that defensins prevent water loss from the skin. The 8-in-1 BioSerum contains the highest concentration of defensins, meaning that once the serum is applied, penetration into the skin surface other products will be compromised (if "nothing/water goes out" - then "nothing is goes in"). This is a unique property of defensin molecules, therefore we always advise layering the 8-in-1 BioSerum as the last step of the skincare regimen, only sunscreen and makeup (if any) is recommended to be applied on top of the 8-in-1 BioSerum in the morning and nothing layered on top at night.