Unlock the Power of 8 Serums in 1
Newly Redesigned Cleanser Cap
NewBeauty Award: Best Rejuvenating Nail Serum
Newly Redesigned Cleanser Cap
NewBeauty Award: Best Rejuvenating Nail Serum


Unlock the power of Defensins: Regenerate and reveal your skin's youthful vitality through the fusion of innovative cellular science and nature's timeless wound-healing mechanisms.



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  • Wine, Alcohol, and Skin Aging



Best Hair Growth Serum NEXT Winner Body Cream Award Neck Cream Award Inc 5000 Award Eye Cream Innovator Award Innovator Award Dermatology Times Award Excellence Award




evidence-based, revolutionary technology

defenage video

Time-defying Defensin molecules boost new skin, outdating the endless repairing and covering up of signs of skin aging. Scientific research shows that Defensins can reprogram dormant cells in our body to promote newer-, healthier- and truly youthful-looking new skin. Defensin molecules visibly rejuvenate the skin in a short period of time, resulting in a brighter-looking skin tone, an improvement in the appearance of dark spots, pores, fine lines and wrinkles, and preserving skin moisture. The scientists at DefenAge® implemented this revolutionary discovery in our formulas. DefenAge® is a beauty brand that formulates a range of anti-aging skincare products that harness the Defensins’ natural skin rejuvenation power. Defensins are exclusive to DefenAge, the technology is patented, and can be combined with almost any skin care regimen.


studies show that skin can naturally turn back the clock

We thoroughly tested and validated all of DefenAge’s formulas and technology in 15 clinical studies.

DefenAge “globally improves the visual appearance of aging skin… without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin,” – says the most comprehensive clinical research on the skin rejuvenation properties of defensins, published in the Journal of Drugs in Dermatology (J Drugs Dermatol. 2018;17(4):426-441) .

Over 5 years, DefenAge has been widely used by aesthetic professionals in their practices as a universal anti-aging and preventive solution. They recommend DefenAge to their clients to address the appearance of these top skin concerns: loss of firmness, contour definition, fine lines and wrinkles, enlarged pores, dark spots and pigmentation, uneven skin tone, surface imperfections, dark eye circles, dullness, glow and radiance, skin clarity, loss of moisture, dryness, rough texture, skin softness, and excessive oiliness, and use to enhance visible results of the microneedling and aesthetic procedures.


visible health, radical age correction, authentic skin rejuvenation


clean skincare • clean formulas • clean ingredients

DefenAge committed to clean technologies from the very beginning, 5 years ago when it just started. The safety and purity of our products is DefenAge’s philosophy. We carefully review background information on each ingredient that we add into our products and follow new developments, research, and recommendations. We are proud to pioneer an exclusion of animal- and human- derived ingredients from skincare. Find out why it is important and review an extensive list of harmful and compromised ingredients and substances that are banned from being used in DefenAge on our Clean Beauty page.

All DefenAge formulas are dermatologist-tested and cruelty free.


“DefenAge really represents a major advanced paradigm shift seen once per decade. The science is remarkable.”

Amy Taub

MD, Dermatologist, Illinois

“The clinical results put DefenAge into the best-in-class category for age-reversing skincare. This truly is a landmark product.”

Vivian Bucay

MD, Dermatologist, Texas

“DefenAge resulted in significant skin improvement to patient wrinkles, texture, pigmentations, and pores within six weeks without any remarkable side-effects.”

Gordon Sasaki

MD, FACS, California

“Defensin-molecules are a new era in skin rejuvenation, they message our body to create new skin by activating the dormant reserve of “fresh” cells in the body.”

Gregory Keller

MD, FACS, California


testimonials • ratings • experiences • stories

“In six short weeks I experienced dramatic improvements in the radiance, texture, and appearance of my complexion. Defenage exceeded all of my expectations. Never before have I endorsed a product.”

E. L., Hawaii

“I have spent thousands on high end products and organic health store product natural solutions. This is the only product that doesn’t cause my eyes to be puffy in the mornings. Everyone has commented on how great my skin looks.”

P. N., California


DefenAge “is the next biggest game-changer in topical products for anti-aging.”

“The answer to aging is here. When used diligently, standout results can finally be achieved at home.”

“I’ve been going back and forth about getting {wrinkle relaxers}, but after starting this routine, I can hold off a little longer.”


authentic products

Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled. Quality is NOT guaranteed when DefenAge products are sold by Amazon, eBay, Walmart, Skincare Solutions Store, Healthy Glow Skin Store, Skin Elite (skinelite.com), Harben House or other unauthorized sources.

All cosmetic products are made in U.S.A.


We stand by our product and are confident that you will be completely satisfied! If you are unhappy with your purchase for any reason, contact us within 30 days of purchase and we will honor your decision to return that item for a refund or for store credit. To make your experience as simple as possible, we offer free return shipping to customers who choose to return for a store credit. Customers who choose to return their purchase for a refund will be issued a refund in the full amount of the returned purchase less the cost of shipping and handling (services rendered). All refunds will be credited to the same account used for the initial purchase.

This Money Back Guarantee Policy excludes wholesale purchases and purchases of limited edition products.

Limited Edition Products: All limited edition items must be returned new, unused, unopened, and with all the security seals still in place.


Skin, Age and Aesthetics: It’s Not Just Vanity

by Eliza Cabana, aesthetic and skin rejuvenation guru

Your skin paints a picture of internal health and vitality. Call it anti-aging or simply aging well, one expert offers insights into why we’re preoccupied with our skin as well as skin rejuvenation tips from top beauty brands to keep it looking healthy and beautiful.


The Skin Care Essentials You Need Regardless of Your Skin Type

There are certain skin care products that all skin types can benefit from, including an under-eye cream, moisturizer, and serum. There are also tried-and-true ingredients that work well on all skin types, such as antioxidants and hyaluronic acid. Some skin rejuvenation formulas are formulated for all skin types and work to address common complaints such as the appearance of fine lines, wrinkles, or dark under-eye circles.


Naturally Rejuvenate Your Skin with These Skin Care Products

Skin rejuvenation in the form of topical skin care products is one of the best ways to improve and maintain the look of skin. The best products will address the appearance of fine lines and wrinkles, the look of the skin’s tone and texture, and improve hydration levels. Learn more about what to look for in your skin rejuvenation products to ensure you are using formulas that actually work.


Kick Off the New Year with an Effective, New Skin Care Routine

If a new year means committing to a consistent skin care routine with high-quality rejuvenating products, now is the time to embrace it. The appearance of your skin is a sign of health and radiance, so you want to use products that help brighten the look of your complexion and reduce the appearance of fine lines and wrinkles. Regardless of your age, you deserve healthy, bright-looking skin.


Get Glowing Skin with DefenAge’s High-Performing Skin Rejuvenation Products

Why cover up visible signs of aging when you can make brand-new, healthy skin cells? Skincare products from DefenAge do just that. Using proprietary Age-Repair Defensins, you can prompt dormant cells to wake up and make brand-new cells. This high-performing ingredient is the key to skin that appears smoother, firmer, and brighter. Try the 8-in-1 BioSerum and 24/7 Barrier Balance Cream from DefenAge today.

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Check the authenticity and expiration date of your products by entering the batch number located on the bottom of each bottle.