Dermatologist Recommended Skincare for Skin Rejuvenation
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Anti-aging Skincare Promo

A skincare regimen easy as 1-2-3 with age-defying, skin rejuvenation results in little as 6 weeks.


evidence-based, revolutionary technology

Time-defying defensin molecules boost new skin, outdating the endless repairing and covering up of signs of skin aging.

Scientific research shows that defensins can reprogram dormant cells in our body to promote newer-, healthier- and truly youthful-looking new skin. Defensin molecules visibly rejuvenate the skin in a short period of time, resulting in a brighter-looking skin tone, an improvement in the appearance of dark spots, pores, fine lines and wrinkles, and preserving skin moisture. The scientists at DefenAge® implemented this revolutionary discovery in our formulas.

DefenAge® is a beauty brand that formulates a range of anti-aging skincare products that harness the defensins’ natural skin rejuvenation power. Defensins are exclusive to DefenAge, the technology is patent-pending, and can be combined with almost any skin care regimen.


study shows that skin can naturally turn back the clock

  • We thoroughly tested and validated all of DefenAge’s formulas and technology in 15 clinical studies.

DefenAge “globally improves the visual appearance of aging skin… without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin,” – says the most comprehensive clinical research on the skin rejuvenation properties of defensins, published in the Journal of Drugs in Dermatology (J Drugs Dermatol. 2018;17(4):426-441).

Over 5 years, DefenAge has been widely used by aesthetic professionals in their practices as a universal anti-aging and preventive solution. They recommend DefenAge to their clients to address the appearance of these top skin concerns: loss of firmness, contour definition, fine lines and wrinkles, enlarged pores, dark spots and pigmentation, uneven skin tone, surface imperfections, dark eye circles, dullness, glow and radiance, skin clarity, loss of moisture, dryness, rough texture, skin softness, and excessive oiliness, and use to enhance visible results of the microneedling and aesthetic procedures.

Anti-Aging Treatment

Clean beauty

DefenAge DOES NOT contain:

The safety and purity of our products is DefenAge’s philosophy. We carefully review background information on each ingredient that we put into our products and follow new developments, research, and recommendations. We are proud to pioneer an exclusion of animal- and human- derived ingredients from skincare. We guarantee that the ingredients below are NOT be found in our formulas: abrasives, aluminum salts, animal-derived ingredients, BPA, BHT/BHA, chemical sunscreens, chemical sunscreens (oxybenzone, avobenzone, and octinoxate), coal tar, colorants, formaldehyde-releasing agents, formaldehydes, gluten ingredients (no wheat, oats, barley), growth factors, human-derived ingredients, hydroquinone, irritating acids, mineral oil, oxybenzone, parabens, paraffin, petrolatum, phthalates, polyethylene and polypropylene (microbeads), propylene glycol, retinyl palmitate, sodium laureth sulfate, sodium lauryl sulfate, strong emulsifiers, sulfates (SLS and SLES), talc, toluene, triclocarban, triclosan, triethanolamine. Fragrance free options are available for all DefenAge formulas.

All DefenAge formulas are dermatologist-tested and cruelty free.

What doctors say about Defenage

“DefenAge really represents a major advanced paradigm shift seen once per decade. The science is remarkable.”

Amy Taub

MD, Dermatologist, Illinois

“The clinical results put DefenAge into the best-in-class category for age-reversing skincare. This truly is a landmark product.”

Vivian Bucay

MD, Dermatologist, Texas

“DefenAge resulted in significant skin improvement to patient wrinkles, texture, pigmentations, and pores within six weeks without any remarkable side-effects.”

Gordon Sasaki

MD, FACS, California

“Defensin-molecules are a new era in skin rejuvenation, they message our body to create new skin by activating the dormant reserve of “fresh” cells in the body.”

Gregory Keller

MD, FACS, California

Real people are saying

testimonials • ratings • experiences • stories


“In six short weeks I experienced dramatic improvements in the radiance, texture, and appearance of my complexion. Defenage exceeded all of my expectations. Never before have I endorsed a product.”

E. L., Hawaii

“I have spent thousands on high end products and organic health store product natural solutions. This is the only product that doesn’t cause my eyes to be puffy in the mornings. Everyone has commented on how great my skin looks.”

P.N., California

Featured in

DefenAge “is the next biggest game-changer in topical products for anti-aging.”

Dermatology Times

“The answer to aging is here. When used diligently, standout results can finally be achieved at home.”

Beauty Report

“I’ve been going back and forth about getting Botox, but after starting this routine, I can hold off a little longer.”


Quality guarantee

authentic products

Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled. Quality is NOT guaranteed when DefenAge products are sold by Amazon, eBay or other unauthorized sources.

All cosmetic products are made in U.S.A.

Money back guarantee

We stand by our product and are confident that you will be completely satisfied! If you are unhappy with your purchase for any reason, contact us within 30 days of purchase and we will honor your decision to return that item for a refund or for store credit. To make your experience as simple as possible, we offer free return shipping to customers who choose to return for a store credit. Customers who choose to return their purchase for a refund will be issued a refund in the full amount of the returned purchase less the cost of shipping and handling (services rendered). All refunds will be credited to the same account used for the initial purchase.

This Money Back Guarantee Policy excludes wholesale purchases and purchases of limited edition products.

Limited Edition Products: All limited edition items must be returned new, unused, unopened, and with all the security seals still in place.

Anti-Aging Blog

featured article

Naturally Rejuvenate Your Skin with These Skin Care Products

Skin rejuvenation in the form of topical skin care products is one of the best ways to improve and maintain the look of skin. The best products will address the appearance of fine lines and wrinkles, the look of the skin’s tone and texture, and improve hydration levels. Learn more about what to look for in your skin rejuvenation products to ensure you are using formulas that actually work. 

Read full article ►

CLINICAL POWER TRIO clinical study tested, DefenAge’s core skin care regimen