A skincare regimen easy as 1-2-3 with age-defying, skin rejuvenation results in little as 6 weeks.

Paradigm shift

evidence-based, revolutionary technology

Why try to repair old skin when you can create new skin?

Scientific research shows the defensin-molecule can reprogram dormant cells in our body to generate visibly newer, healthier and truly youthful NEW SKIN.

Scientists at DefenAge implemented this revolutionary discovery in our formulas. Defensins are exclusive to DefenAge, the technology is patent-pending, and may be combined with almost any skin care regimen.

DefenAge is proven in 15 clinical studies.

Improvement on a global scale

study shows that skin can naturally turn back the clock

  • #PoreEraser
  • #AcneMender
  • #WrinkleRemover
  • #MelaninMasker
  • #TreatmentMultiplier
  • #GlobalFixer

Multi-center placebo-controlled double-blind clinical study shows that DefenAge’s Clinical Power Trio “globally improves the visual appearance of aging skin” and “offers most of the advantages of time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin.”

Journal of Drugs in Dermatology 2018, 17(4): p. 426-441
Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD

Anti-Aging Treatment

Clean beauty

DefenAge DOES NOT contain:

Abrasives, aluminum salts, animal-derived ingredients, BPA, BHT/BHA, chemical sunscreens, chemical sunscreens (oxybenzone, avobenzone, and octinoxate), coal tar, colorants, formaldehyde-releasing agents, formaldehydes, gluten ingredients (no wheat, oats, barley), human-derived ingredients, hydroquinone, irritating acids, mineral oil, oxybenzone, parabens, paraffin, petrolatum, phthalates, polyethylene and polypropylene (microbeads), propylene glycol, retinyl palmitate, sodium laureth sulfate, sodium lauryl sulfate, strong emulsifiers, sulfates (SLS and SLES), talc, toluene, triclocarban, triclosan, triethanolamine. Fragrance free options are available for all DefenAge formulas.

All DefenAge formulas are dermatologist-tested and cruelty free.

What doctors say about Defenage

“DefenAge really represents a major advanced paradigm shift seen once per decade. The science is remarkable.”

Amy Taub

MD, Dermatologist, Illinois

“The clinical results put DefenAge into the best-in-class category for age-reversing skincare. This truly is a landmark product.”

Vivian Bucay

MD, Dermatologist, Texas

“DefenAge resulted in significant skin improvement to patient wrinkles, texture, pigmentations, and pores within six weeks without any remarkable side-effects.”

Gordon Sasaki

MD, FACS, California

“Defensin-molecules are a new era in skin rejuvenation, they message our body to create new skin by activating the dormant reserve of “fresh” cells in the body.”

Gregory Keller

MD, FACS, California

Real people are saying

testimonials • ratings • experiences • stories


“In six short weeks I experienced dramatic improvements in the radiance, texture, and appearance of my complexion. Defenage exceeded all of my expectations. Never before have I endorsed a product.”

E. L., Hawaii

“I have spent thousands on high end products and organic health store product natural solutions. This is the only product that doesn’t cause my eyes to be puffy in the mornings. Everyone has commented on how great my skin looks.”

P.N., California

Featured in

DefenAge “is the next biggest game-changer in topical products for anti-aging.”

Dermatology Times

“The answer to aging is here. When used diligently, standout results can finally be achieved at home.”

Beauty Report

“I’ve been going back and forth about getting Botox, but after starting this routine, I can hold off a little longer.”


Quality guarantee

authentic products

Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled. Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources.

All cosmetic products are made in U.S.A.

Money back guarantee

We stand by our product and are confident that you will be completely satisfied! If you are unhappy with your purchase for any reason, contact us within 30 days of purchase and we will honor your decision to return that item for a refund or for store credit. To make your experience as simple as possible, we offer free return shipping to customers who choose to return for a store credit. Customers who choose to return their purchase for a refund will be issued a refund in the full amount of the returned purchase less the cost of shipping and handling (services rendered). All refunds will be credited to the same account used for the initial purchase.

This Money Back Guarantee Policy excludes wholesale purchases and purchases of limited edition products.

Limited Edition Products: All limited edition items must be returned new, unused, unopened, and with all the security seals still in place.

CLINICAL POWER TRIO clinical study tested, DefenAge’s core skin care regimen