Give Your Hands Five-Star Treatment!


Give Your Hands Five-Star Treatment!

$29/mo with Affirm. Use Amazon Pay at Checkout.


DefenAge Hand Trio Details

The Ultimate Hand Trio is a unique and exclusive hand repair treatment that helps refresh the skin on your hands and elbows via topical application. This hand moisturizing routine uses DefenAge's Hero Blend of age-repairing Defensins, which trigger young and healthy cells to produce fresh new skin.

Maintaining a daily skincare routine for your hands is just as important as caring for the skin on your face. Since we do not apply makeup to our hands to offer protection, they can start to show signs of premature aging sooner. The Ultimate Hand Trio for dry hands repairs, hydrates, and renews in 3 easy steps:

  • 2-Minute Reveal Masque Gently removes dead skin cells to reveal fresh new skin and a brighter tone. It was named The Best Brightening Mask by NewBeauty Magazine. This hydrating mask is supplied in full size, 2.5 oz.
  • 10 Luxe Hand & Body Cream Protects and restores lost moisture via multi-action activities and an advanced four-pillar revolutionary formulation. This moisturizing hand cream is supplied in full size, 4 fl. oz.
  • 8-in-1 BioSerum Promotes new skin via 5-time concentrated Defensins and visibly renews the skin's firmness, elasticity, and texture. This enhanced serum is supplied in mega-size, 1.5 fl. oz.

Try this luxurious, three-step professional hand moisturizer routine for yourself. You could experience firmness in the skin's elasticity, brighter tone, and more hydrated skin in as little as 7-10 days.

Here are additional benefits of our hand trio for dry hands.

  • •  Provides anti-aging benefits on a global scale while reversing signs of premature skin aging and sun damage.
  • •  Promotes new, ‘younger’ skin.
  • •  Effective on both the hands and elbows and visibly revives their smooth texture and revitalizes softness.
  • •  Visibly enhances firmness and cosmetic elasticity.
  • •  Refines the surface skin texture.
  • •  Provides both instant and long-lasting hydration, including in dry or winter climates.
  • •  Boosts natural moisture retention, leaving skin feeling firmer and plumper immediately.
  • •  Relieves dryness and itching.
  • •  Balances the skin’s barrier function.
  • •  Promotes the skin’s natural Hyaluronic Acid, Laminin, and Elastin.
  • •  Improves visible skin thickness.
  • •  Skin tone appears luminous and healthy.
  • •  Acts fast: first results from ‘immediate’ to 1 week, full range of results in 6 weeks.
  • •  Can be used together with a Retinol if Retinol is tolerated. Effective as a Retinol alternative for Retinol-sensitive skin to deliver Retinol-like results.
  • •  Free from irritants, suitable for all skin types.
  • •  Meets clean beauty standards and is fragrance-free

All of our moisturizing hand products in the collection are supplied in their largest available sizes and in their original individual packaging.

All hydrating hand products are made in the U.S.A.

How to Use Our Hand Repair Kit

Hand and Elbow Treatment Ritual

1-Step Multi-Cleanse

WEEKLY - Exfoliation

2-Minute Reveal Masque

1-2 Xs A Week

Once or twice a week after washing your hands, dry your skin thoroughly. Apply a dollop of the hydrating hand cream masque, about the size of a quarter, to both hands and the same amount of masque on both elbows. Using dry fingertips, gently massage the masque in a circular motion for 20 seconds or less, depending on skin sensitivity. Wait 2 minutes. With moistened fingertips, massage until the crystals are completely dissolved. Rinse treated areas thoroughly. We recommend applying the hand moisturizer masque on the elbows before showering for easy wash-off.
Not recommended for extremely sensitive or irritated skin.

3D Eye Radiance Cream

STEP TWO - Moisturizing

10 Luxe Hand & Body Cream

Daily: AM | PM

Apply the moisturizing hand cream once or twice daily after washing your hands or showering. Distribute and massage one pump of the hand cream on both hands, and use another pump to treat both elbows. Wait 30 seconds, then apply 8-in-1 BioSerum | STEP THREE.
Suitable for all skin types.

8-in-1 BioSerum


8-in-1 BioSerum

Daily: AM | PM

Apply after 10 Luxe Hand & Body Cream.

Thirty seconds after applying 10 Luxe Hand & Body Cream, distribute and massage 1 pump of serum between both hands and use another pump on both elbows. While the skin is still moist, lightly massage it into the skin. Follow with sunscreen.
Suitable for all skin types.


These hydrating products are for external use only. Keep out of the eyes. If the product enters your eyes, rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

Hand Cream Clinical Studies

The multi-parameter clinical study is in a clinical dermatology magazine, and the results are very exciting! Join DefenAge® Skin Club to receive an update as soon as the data becomes publicly available. It is free and does not require a subscription or purchase commitment.

Be the first to try this high-performing cosmetic hand cream treatment first-hand!

Hand Moisturizer Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

All hydrating hand cream formulas in this bundle are fragrance-free.


We have carefully formulated our hand cream products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.


The bottles, tubes, and boxes of these hand cream products are fully recyclable; please recycle.

Our hand moisturizers are not tested on animals.

Hand Repair Cream Guarantees

Quality Guarantee

The quality of our hand cream products is guaranteed ONLY when sold by defenage.com or authorized professionals; otherwise, it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 


These hand cream products qualify for the Money-Back Guarantee.

In case of a refund, all products in this bundle should be returned.

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