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POWER PAIR - HYDRATION+
Anti-Aging Serum & Face Moisturizer, Hydration+ Edition
Visibly smooth signs of aging, boost hydration, and support a stronger, healthier-looking skin barrier
[ $304 value ]

New An extra level of hydration.

2026 Holiday Promotion

27 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

POWER PAIR - HYDRATION+

Anti-Aging Serum & Face Moisturizer, Hydration+ Edition
Visibly smooth signs of aging, boost hydration, and support a stronger, healthier-looking skin barrier
[ $304 value ]

New An extra level of hydration.

2026 Holiday Promotion

27 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

$221.00 Regular Price $304.00
Claim Exclusive Rewards
SKU
10225-m

Skincare Anarchy AwardNEXT AwardELITE Lifestyle AwardInnovator Award

Elevate your skincare with DefenAge’s Power Pair – Hydration+ Edition. Featuring two of our best-selling, dermatologist-recommended formulas, this high-performance duo pairs advanced age repair with enhanced hydration to visibly improve fine lines, wrinkles, firmness, tone, and overall skin health. Powered by Defensin-molecule technology, this simple routine supports the skin’s natural renewal process while delivering lasting hydration and a smooth, refined matte finish. Visible results can begin in as little as one week.

Key Benefits:

  • • Age-Repair Defensins®: Activates dormant skin cells to support natural renewal and visibly improve multiple signs of aging.
  • • Enhanced Hydration: Delivers increased hydration and lasting comfort to help skin feel soft, smooth, and replenished.
  • • Barrier Support: Helps strengthen and support the skin’s natural moisture barrier for healthier-looking, more resilient skin.
  • • Simplicity, Maximum Impact: Two high-performance formulas deliver targeted age repair and hydration in a streamlined daily routine.

Routine Contents:

  • • 8-in-1 BioSerum | Mega Size, 1.5 fl. oz.
  • • 24/7 Barrier Balance Cream - Hydration+ Edition | Full Size, 1.5 fl. oz.

All products in this collection are supplied in original individual packaging.

Made in the U.S.A.

How To Use

DIRECTIONS

 

24/7 Barrier Balance Cream

24/7 Barrier Balance Cream-Hydration+

Daily: AM | PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Suitable for all skin types.
Suitable for all skin types.

 

 

8-in-1 BioSerum

8-in-1 BioSerum

Daily: AM | PM

After applying 24/7 Barrier Balance Cream, place 1 pump of 8-in-1 BioSerum onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.

 

 

WARNINGS

For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

 

 

Clinical Studies

Study on Defensins and Skin Rejuvenation: What It Means for You

Background:

Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.

What are Defensins?

Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.

The Study:

  1. This was a double-blind, vehicle-controlled study, meaning neither the participants nor the researchers knew who was using the Defensin-containing product and who was using a placebo (vehicle).
  2. Participants included men and women with signs of skin aging, such as fine lines, wrinkles, uneven skin tone, and rough texture.
  3. They applied either the Defensin-containing product or a placebo product to their face for 6 weeks.

Key Results:

  1. Visible Improvement: Participants who used the Defensin-containing product showed significant improvement in skin quality compared to those who used the placebo. They experienced smoother skin, fewer wrinkles, improved texture, and a more even skin tone.
  2. Safety: The product was well-tolerated by participants, with no major side effects, making it a safe option for most people.

What This Means for You:

This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.

CLINICAL STUDY ►

Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

All formulas in this collection are fragrance-free.

CLEAN BEAUTY

We have carefully formulated our hand cream products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.

GREEN PLANET

The tubes and boxes are fully recyclable; please recycle.

Our products are not tested on animals.

Guarantees

MONEY BACK GUARANTEE

This product is qualified for the Money Back Guarantee.

In case of a refund, all products in this bundle should be returned.
Return Policy ►

 

FAQ's
What's included in the DefenAge Power Pair Hydration+?
The Power Pair Hydration+ brings together the 8-in-1 BioSerum in the mega size, 1.5 fl. oz., and the 24/7 Barrier Balance Cream Hydration+ Edition in the full size, 1.5 fl. oz. Choosing the Boost option adds the 7X Calming Complex in the full size, 0.5 fl. oz., for an extra layer of calm alongside the routine.
What are the main benefits of the DefenAge Power Pair Hydration+?
The DefenAge Power Pair Hydration+ works on two fronts. Age-Repair Defensins activate dormant skin cells to support natural renewal and visibly improve multiple signs of aging, while the Barrier Balance Cream Hydration+ Edition delivers enhanced hydration and lasting comfort along with a stronger, healthier-looking moisture barrier. Together, they leave skin feeling soft, smooth, and replenished, with visible results beginning in as little as one week.
What's the difference between the Power Pair and the Power Pair Hydration+ Edition?
Both bundles pair the 8-in-1 BioSerum with a 24/7 Barrier Balance Cream, and both deliver Age-Repair Defensins and barrier support. The difference comes down to hydration level: the standard Power Pair uses the original Barrier Balance Cream for balanced, everyday hydration with a natural finish, while the Power Pair Hydration+ uses the enhanced formula, built for skin that wants more moisture and comfort, absorbing into a smooth, velvety matte finish.
Does the DefenAge Power Pair Hydration+ contain Vitamin C?
The Power Pair Hydration+ doesn't include Vitamin C in its formula, and pairing it with a Vitamin C serum works well for anyone already using one. Age-Repair Defensins support the skin's natural renewal process, helping new skin cells replace pigmented ones over time, so this duo can help address concerns like uneven tone right alongside whatever Vitamin C brings to the routine.
What is the application order for the Power Pair Hydration+, and how does the 7X Calming Complex fit in if I have the Boost?
Cleansed skin comes first, followed by any other treatments already in the routine, like a Vitamin C serum, retinol, or tretinoin. With the Boost option, the 7X Calming Complex goes on next, applied for its full 10 to 14 day cycle, either as a standalone step or repeated 4 to 6 times a year alongside the rest of the routine. From there, twice daily the 24/7 Barrier Balance Cream Hydration+ Edition goes on, up to two pumps massaged in while skin is still moist, avoiding the eye area. The 8-in-1 BioSerum follows, one pump massaged around the eyes and over the face, with a second pump for the neck and décolleté. Sunscreen rounds out the morning routine.
What skin types is the DefenAge Power Pair Hydration+ suitable for?
Both the 8-in-1 BioSerum and the 24/7 Barrier Balance Cream Hydration+ Edition are formulated to work for all skin types, from oily and combination to dry and sensitive. Fragrance-free and built around Age-Repair Defensins, the Power Pair Hydration+ fits easily into an existing routine, and the enhanced hydration level makes it a particularly strong fit for skin that runs dry or feels tight.
What technology powers the DefenAge Power Pair Hydration+?
Age-Repair Defensins sit at the center of both products in the Power Pair Hydration+. These molecules work by activating dormant skin cells, supporting the body's own renewal process rather than working against it. Backed by more than 30 clinical studies, the technology is what sets the BioSerum and Barrier Balance Cream Hydration+ Edition apart from typical anti-aging formulas.

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.934509 / 5 from 1588 reviews.

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Review highlights

Reviews

Excellent morning routine

"I have fortuitously been introduced to the Defenage line of products. So far I’ve tried and love the 8 in 1 Bioserum, the lip product and the 2 minute reveal. I like this company’s customer service and although it’s pricey I stick up during their great sales. I’m 61 and people say I look a lot younger. Using and buying these products reminds me to stay out of the sun."

— Joanne C. (5/5)

Essential Step in Skincare Routine

"First Step after cleansing, immediate feeling of hydration. My skin, which I would describe as naturally dry had become soft and dry no more! I love this luxurious cream and will use it forever. I purchase in bundles at a great value."

— Valerie B. (5/5)

Good so far

"I havnt been using for more than a few weeks but u can see my skin tone getting lighter to my natural tone. Pores are minimizing and skin feels more hydrated and plump. Slightly minimizing fine lines but hoping to see more effective results for the fine lines"

— Corrine A. (5/5)

Great product

"I got a sample from the med spa and really liked the results I was getting so I purchased the full size."

— HEATHER C. (5/5)

Back for more

"I’ve tried so many things and this seems to be working on my skin texture and balanced hydration."

— JB (5/5)

8-In-1 Bioserum

"It is still too soon but I like the product and the science and clinical studies conducted I will continue to purchase"

— Bernadine D. (5/5)

Defenage

"The 8 in 1 serum is very effective . I have been getting compliments on my skin tone and condition since I started using the product 10 years ago. It was recommended by a dermatologist and from a plastic surgeon"

— Amy B. (5/5)

Love the texture

"I was concerned that the recommended 1 pump was not enough but surprisingly it provides full coverage and goes on very silky smooth. I can’t wait to see the results."

— Vicky C. (5/5)

So powerful must avoid during eyebrow tattoo and lip blushing

"This product works almost to well. Because of the effective cell turnover working so well and so rapidly, my permanent makeup artist has prohibited my Defenage for the 4 weeks following my tattoos. i miss the product and cant wait to get back to using it once my tattoos are fully healed."

— Betsy P. (5/5)

Game changer

"Love how my skin feels"

— Yaretzza P. (5/5)

Q&A