This biologically-advanced serum provides an unprecedented concentration of defensin molecules in the Age-Repair Defensin^® Complex.

DefenAge's iconic best seller.

Inclusive and comprehensive AM & PM skincare set promotes cell renewal, diminishes the signs of aging, and restores skin moisture. Up to 27% SAVINGS over buying individually!

DefenAge's signature dermatologist recommended skin care treatment. We recommend starting DefenAge with the Clinical Power Trio. 

Intense hydrating cream infused with Age-Repair Defensins®, multi-action barrier balancing ingredients and skin brightening skincare actives.

Improves the visible health of delicate skin around the eyes. Technology-loaded treatment with extended performance.

Multi-award winner.

New luxe anti-aging neck tightening and moisturizing cream infused with leading scientific advances.

Trial size is available.

Beauty Breakthrough - Achieve a New Level of Lip Rejuvenation! Visibly enhances fullness, smoothness, and overall lip health. Designed to support natural lip cell renewal and reduce the appearance of fine lines, delivering softer, more defined lips with a hydrated, plump appearance.

First-ever defensin-containing cream for the hands and body! Multi-functional performance. The first of its kind. Experts recommend. Trial size is available.

Visibly improves the natural health and overall condition of the nails and skin around the nails. Designed to help revitalize nails via direct messaging to nail-producing cells. Smoother and stronger nail plate, hydrated and smoother skin.

See amazing skin-brightening in minutes with this Triple Enzyme exfoliating mask. Instantly resurfaces, refines, and softens skin.

In seconds, melt away surface debris, instantly dissolve heavy makeup and waterproof mascara, and help liquefy impurities in pores.

A well-rounded routine sets the foundation for the day, protecting your skin from environmental stressors, replenishing moisture, and enhancing its natural glow. 

Our skin loses moisture while we sleep. Use our high-performing nighttime routine to repair the day’s damage and promote the skin’s natural renewal. 

Complete skincare set to take care of the neck and décolletage area, where aging is often more noticeable. Up to 20% SAVINGS over buying individually! 

Give your hands five-star treatment! High-performing cosmetic treatment for the hands and elbows reverses signs of skin aging and sun damage.

Experience the celebrity skincare secret of New York Fashion Week with the Runway Glow Collection—transform your complexion into luminous, rejuvenated skin. 28% SAVINGS over buying individually!

Get your skin glowing with the perfect wedding skincare routine! Check out how this celebrity bride used it and what results she got! (up to $592 value)

Discover a skincare regimen specially crafted for those who spend significant time in the kitchen, designed to protect, repair, and rejuvenate your hands, nails, arms, and neck. 26% SAVINGS! 

A travel-size version of the CLINICAL POWER TRIO, DefenAge's core skincare regimen, offering a 2-week supply in a cosmetic bag. TSA-friendly.

An all-inclusive, luxury skincare regimen for the face and body in a trial-size, 2-3 day supply. Try them all!

A trial size of the CLINICAL POWER TRIO, DefenAge's signature regimen, 2-3 day supply.

This rejuvenation-inspired, super-charged scalp serum revitalizes the environment surrounding the hair follicles, creating an optimal ecosystem for the follicles to flourish. Contains 48 natural proven ingredients.

A complete, professional-grade, annual skin detailing service tailored to men’s need. We recommend using the Booster once or twice a year to jumpstart the skin for high-performance and following with the Provision for skin maintenance until the next boost.

A scientifically proven, easy-to-use skincare system tailored and formulated directly to the unique needs of men’s skin. It is designed for daily skin maintenance and promotes healthy skin that looks fresh, energized, and young.

A clinically backed, easy-to-use anti-aging skincare essential tailored to the unique needs of men. Designed for daily use, it promotes healthy, resilient skin that looks fresh, energized, and youthful.

Simple to use systems for skin-, scalp- and beard- care, developed for men. Jump start the skin with the Booster and maintain with the Provision. The 150K Hair Follicle Serum promotes sustainable health and wellness of the scalp and skin under the beard.

This rejuvenation-inspired, super-charged scalp and beard serum revitalizes the environment surrounding the hair follicles, creating an optimal ecosystem for the follicles to flourish. Contains 48 natural proven ingredients.

Luxurious sleep experience and beauty benefits. Natural 100% silk is less absorbent than cotton, helping skin retain valuable moisture while we sleep.

Give the gift of DefenAge to your friens and family! Our e-Gift Card is an ideal Birthday and Holiday Gift that was just released!