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360-Rejuvenation Nail Root Serum Details

Getting to the Root of Healthy Nails.

The 360-Rejuvenation Nail Root Serum is the first-ever nail rejuvenation serum that utilizes Defensin-molecules to target the real source of healthy nails – the root! As we age, our nails become thinner, weaker, and more fragile or brittle. Life habits, including our diet, daily tasks, and hobbies, also affect our nails. The root of nail growth is located in the nail matrix, in the LGR6+ cells that produce our nails and are responsible for nail regeneration.

The new 360-Rejuvenation Nail Root Serum is designed to help revitalize nails via direct messaging to nail-producing cells.

Discover the Transformative Power of the 360-Rejuvenation Nail Root Serum


Dive into the world of unparalleled nail care with the 360-Rejuvenation Nail Root Serum, where visible results speak volumes:

  • •  Smoother Nails: Up to 92% smoother nails, significantly minimizing both vertical and horizontal ridges and lines.
  • •  Enhanced Strength: A robust increase in nail strength by up to 54%.
  • •  Superior Hydration: An impressive surge in hydration, up to 78% more for the skin surrounding your nails.
  • •  Timely Improvement: Witness the initial signs of improvement in just 30 days, with continued enhancement over the span of 3 months.

* Findings are based on a clinical study of participants aged 40-58. Individual results may vary.


The 360-Rejuvenation Nail Root Serum stands out by fostering direct communication with the nail-producing matrix, thereby revitalizing your nails from their very origin. This unique approach is complemented by a suite of benefits designed to elevate the health and aesthetics of your nails and the skin around them:

  • •  Visibly Enhanced Nail and Skin Condition: Witness a noticeable improvement in the overall health and appearance of your nails and skin.
  • •  Increased Smoothness: Enjoy smoother nails as our serum works to enhance their natural texture.
  • •  Strengthened Nails: Reduce fragility and breakage with an increase in nail strength.
  • •  Hydration and Nourishment: Provide your nails and surrounding skin with the essential hydration and nourishment they crave.
  • •  Keratin Production: Boost the natural production of keratin for healthier nail appearance.
  • •  Antioxidant Protection: Benefit from a full spectrum of antioxidant protection against daily environmental stressors.
  • •  Optimized Nail Growth Metrics: Experience optimized nail growth metrics, leading to better, more visible results.

Embark on your journey to healthier, more resilient nails with the 360-Rejuvenation Nail Root Serum, where science meets beauty to transform your nail care routine.

Why the 360-Rejuvenation Nail Root Serum Is Different

Our nail serum is an excellent cosmeceutical care for the nails and surrounding skin. Instead of cosmetically "fixing" the old nail plate by bringing chemicals into it, like common nail serums do, the 360-Rejuvenation Nail Root Serum addresses the cause of the problem by targeting the nail-producing matrix in the nail root for NEW stronger, smoother, rejuvenated nails. Here’s what makes the 360-Rejuvenation Nail Root Serum different:

  • •  Contains a serum-high level of Defensin-molecules that specifically target nail-producing cells.
  • •  Infused with a powerful collection of high-performing ingredients for a comprehensive nail rejuvenation approach, including Tara tree fruit extract, niacinamide, biotin, squalene, pentanol, methionine, and an advanced, know-how protected, anti-inflammatory and soothing complex.
  • •  Delivers a wide range of benefits in one product.
  • •  Free from drugs and hormones.
  • •  Studied in an independent, third-party clinic and was shown to be effective.

FAQ: Where Does This Odor Come From?

The 360-Rejuvenation Nail Root Serum does not contain fragrance or chemicals to absorb the organic sent. The odor you can smell is the natural scent of key performance ingredients. The “smelliest” one is an essential amino acid, called Methionine. It is crucial to keep our nails strong, therefore our scientists added it to the 360-Rejuvenation Nail Root Serum. BTW, this amino acid is also often taken as a food supplement.

Made in the U.S.A.


  • 1. Lehoczky JA, Tabin CJ. Lgr6 marks nail stem cells and is required for digit tip regeneration. Proceedings of the National Academy of Sciences USA 2015 Oct 27;112(43):13249-54
  • 2. Dolan CP, Dawson LA, Muneoka K. Digit tip regeneration: merging regeneration biology with regenerative medicine. Stem Cells Translational Medicine. 2018 Mar;7(3):262-270.
  • 3. Mahmud N, Eisner C, Purushothaman S, et al. Nail-associated mesenchymal cells contribute to and are essential for dorsal digit tip regeneration. Cell Reports. 2022 Dec 20;41(12):111853.

How to Use The 360-Rejuvenation Nail Root Serum

360-Rejuvenation Nail Root Serum Directions

Designed to improve the natural health of nails and their surrounding skin. Please follow the directions below for optimal results.

Nail Serum


Use twice daily, in the morning and evening.


With the built-in brush, apply 1-2 pumps of the serum on all the nails and on the skin around the nails on both hands.


Push the button of the bottle to release a pump of the serum on top of the brush and then distribute the serum across all the nails and the skin around the nails.


Start with the first phalange, and then brush the serum toward the end of the nail.


Ensure the serum is distributed to the skin surrounding all sides of the nail.


Leave serum on for at least 30 minutes or overnight.


Okay to use on fingernails and toenails.


  • • For first use, it may take 5-7 pumps before product starts to dispense.
  • • For better results, do not cover nails with nail polish. If nail polish is used, the serum may not penetrate through the nails.
  • • Do not wash the serum off after the application. This is a leave-on product, and it should stay on the skin and nails for at least 30 minutes.
  • • Do not use more pumps than recommended (do not overdose).
  • • If used according to directions, one bottle should last 15-30 days.

Clinical Studies of the 360-Rejuvenation Nail Root Serum

The 360-Rejuvenation Nail Root Serum is clinically-tested by a Board-Certified dermatologist and shows an outstanding safety profile (hypoallergenic, non-sensitizing, non-irritating formula).

The efficacy clinical studies show that the defensin-containing serum, applied twice daily, is "effective in improving the overall condition of the nails and skin in the nail root area," including up to 92% smoother nails with visibly fewer vertical and horizontal ridges, up to 54% improvement in nail strength, up to 78% more hydration of the skin around the nails (clinical studies of women and men, ages 40-58; individual results may vary).

Nail Plate Smoothness Has Improved

Nail Plate Smoothness Has Improved

Nail Plate Smoothness Has Improved

Nail Plate Smoothness Has Improved

Nail Plate Smoothness Has Improved

Nail Plate Smoothness Has Improved

Clinical photos are obtained from the study performed by an independent, third-party clinic. Photos have not been retouched.

Nail Plate Became Stronger

Nail Plate Became Stronger

Clinical data is obtained from the study performed by an independent, third-party clinic.

Nail Regeneration Was Triggered as Indicated by PhotoGrammetrix® Image Analysis

Nail Regeneration Was Triggered as Indicated by PhotoGrammetrix® Image Analysis

Clinical data is obtained from the study performed by an independent, third-party clinic.

Moisturization Improvement

Moisturization Improvement

Clinical data is obtained from the study performed by an independent, third-party clinic.

360-Rejuvenation Nail Root Serum Ingredients

Key Performance Ingredients and Technologies

Age-Repair Defensins® | 5X | DefenAge's Exclusive

• Trigger Nail-Producing Matrix to Revitalize Nail •

Defensins are natural molecules known to awaken dormant regenerative cells in our body. Multiple studies demonstrated their tremendous ability in helping our body make beautiful skin, hair, and nails. DefenAge contains an identical copy of human defensins made via biosynthesis; defensins are exclusive to DefenAge.


• Nail Strength •

Methionine is an essential amino acid. It is a crucial building block of the nail.

Tara Tree Fruit Extract

• Protection, Strengthening & Beautifying •

Caesalpinia Spinosa (Tara) Fruit Extract is an outstanding natural antioxidant, shown to be effective in protecting the nails and their keratin structure from damaging free radicals that can be caused by environmental stress, UV light, and harsh chemicals.

Vitamin B Complex | Niacinamide, Panthenol & Biotin

• Hydration • Circulation • Keratin •

Vitamins B3 (niacinamide), B5 (panthenol), and B7 (biotin) are vital components of the nail-supporting system. The vitamins in this complex repair the natural moisturization of the nail and surrounding skin, revive oxygen supply, and activate nail keratin.

Fine Blend of Soothing and Calming Ingredients

• Addresses Inflamm-Aging • Calms Nail Environment •

This formula is infused with a powerful and concentrated composition of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.


The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excluded from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.


We do not test products on animals.


Water (Aqua), Panthenol, Niacinamide, Pentylene Glycol, Squalane, Ricinus Communis (Castor) Seed Oil, Octyldodecanol, Glyceryl Stearate Citrate, Alpha-Defensin 5, Beta-Defensin 3, Biotin, Caesalpinia Spinosa Fruit Pod Extract/Caesalpinia Spinosa Fruit Extract, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Helianthus Annuus (Sunflower) Sprout Extract, Helianthus Annuus Seed Oil Unsaponifiables, Helianthus Annuus Seed Oil, Ribes Nigrum Seed Oil, Rosmarinus Officinalis Leaf Extract, Leuconostoc/Radish Root Ferment Filtrate, Methionine, Epigallocatechin Gallatyl Glucoside, Phospholipids, Tocopherol, Tocopheryl Acetate, Ubiquinone, l-Alanyl-l-Glutamine, Polyglyceryl-3 Stearate, Hydrogenated Lecithin, Phytic Acid, Caprylic/Capric Triglyceride, Pistacia Lentiscus Gum, Polyacrylate Crosspolymer-6, Phenoxyethanol, Albumin, Sodium Benzoate, Potassium Sorbate, Propylene Glycol, Sodium Chloride.
Fragrance free.

360-Rejuvenation Nail Root Serum Guarantees


The quality of the 360-Rejuvenation Nail Root Serum is guaranteed ONLY when sold by defenage.com or authorized professionals; otherwise, it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 


This 360-Rejuvenation Nail Root Serum product qualifies for the Money-Back Guarantee.
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