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FLAWLESS FACE COLLECTION
A comprehensive facial care collection designed to hydrate, protect, and rejuvenate for luminous, youthful-looking skin.
[ $778 value ]

2026 Holiday Promotion

40 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

Black Friday Promotion

Buy One, Get One 70% OFF

Add any 2 of the same item to your bag.

Discount applied automatically.

Black Friday countdown

Limited-time offer. While supplies last.

FLAWLESS FACE COLLECTION

A comprehensive facial care collection designed to hydrate, protect, and rejuvenate for luminous, youthful-looking skin.
[ $778 value ]

2026 Holiday Promotion

40 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

Black Friday Promotion

Buy One, Get One 70% OFF

Add any 2 of the same item to your bag.

Discount applied automatically.

Black Friday countdown

Limited-time offer. While supplies last.

$466.00 Regular Price $778.00
Claim Exclusive Rewards
SKU
10206-m
People Award Oprah Daily Award Beautytap Award: Editor's Pick NewBeauty Award Hall of Fame Award Skincare Anarchy 2025 People en Español Star Product NewBeauty NEXT Award Skincare Anarchy AwardELITE Lifestyle Award NewBeauty Award   The BEST Neck Cream Award | NewBeauty Neck Cream Award | People Eye Cream Award | NewBeauty   Innovator Award Eye Cream Award Best Brightening Mask Award Innovator Award

Elevate your routine with the a complete set of skincare essentials. This all-in-one set includes everything needed for a complete face care regimen, from deep cleansing and targeted treatment to hydration, eye care, neck care, and lip enhancement. Powered by Defensin-molecule technology, each product works together to reduce the appearance of fine lines, improve skin texture, and restore a luminous, healthy glow—perfect for achieving your best skin yet this holiday season.

Key Benefits:

  • • Age-Repair Defensins®: Awakens dormant skin cells to visibly reduce signs of aging.
  • • Barrier-Boosting Hydration: Locks in moisture while strengthening the skin’s natural barrier.
  • • Full-Face Renewal: Targeted treatments that visibly restore vulnerable and problem areas.
  • • Simple, Powerful Skincare: Complete, results-driven skincare in one luxurious set.
  • • Defends Against Inflamm-aging: Helps combat hidden inflammation that accelerates visible signs of aging.

Routine Contents:

  • • 1-Step Multi-Cleanse (Mega Size, 5 fl.oz)
  • • 8-in-1 BioSerum (MEGA Size, 1.5 fl. oz.)
  • • 24/7 Barrier Balance Cream (Full Size, 1.5 fl. oz.)
  • • 2-Min Reveal Masque (Full Size, 2.5 fl.oz)
  • • 3D Eye Radiance Cream (Full Size, 0.5 fl.oz)
  • • 6-Week Perfection Neck Cream (1.5 fl.oz.)
  • • 12-Factor Revitalizing Lip Enhancer (Full Size, 0.25 fl.oz)
  • • NEW 7X Calming Complex (Full Size, 0.5 fl.oz.)
How To Use

DIRECTIONS

1-Step Multi-Cleanse

STEP ONE | 1-Step Multi-Cleanse

Daily: AM | PM

Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with clean towel. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream and 6-Week Perfection Neck Cream).
Suitable for all skin types.

24/7 Barrier Balance Cream

STEP TWO - FACE | 24/7 Barrier Balance Cream

Daily: AM | PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.

3D Eye Radiance Cream

STEP TWO - EYES | 3D Eye Radiance Cream

Daily: AM | PM

After cleansing, while skin is still moist from rinsing, pump a drop of cream onto applicator. Lightly dab three dots of cream above and below each eye. Using applicator, massage cream around eyes. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.

6-Week Perfection Neck Cream

STEP TWO - NECK | 6-Week Perfection Neck Cream

Daily: AM | PM

Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.

7X Calming Complex

ANTI-INFLAMMAGING | 7X Calming Complex

Daily: AM | PM

Please visit the 7X Calming Complex page for the usage directions for this innovative product ►

8-in-1 BioSerum

STEP THREE | 8-in-1 BioSerum

Daily: AM | PM

Apply after the 24/7 Barrier Balance Cream,
3D Eye Radiance Cream, and 6-Week Perfection Neck Cream.

30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.

12-Factor Revitalizing Lip Enhancer

STEP THREE - LIPS | 12-Factor Revitalizing Lip Enhancer

Daily: AM | PM

Please visit the 12-Factor Revitalizing Lip Enhancer page for the usage directions for this innovative product ►

2-Minute Reveal Masque

1-2 Xs A WEEK | 2-Minute Reveal Masque

Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream and 6-Week Perfection Neck Cream).
Not recommended for acne, extremely sensitive or abraded skin.

WARNINGS

For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

Clinical Studies

Study on Defensins and Skin Rejuvenation: What It Means for You

Background:

Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.

What are Defensins?

Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.

The Study:

  1. This was a double-blind, vehicle-controlled study, meaning neither the participants nor the researchers knew who was using the Defensin-containing product and who was using a placebo (vehicle).
  2. Participants included men and women with signs of skin aging, such as fine lines, wrinkles, uneven skin tone, and rough texture.
  3. They applied either the Defensin-containing product or a placebo product to their face for 6 weeks.

Key Results:

  1. Visible Improvement: Participants who used the Defensin-containing product showed significant improvement in skin quality compared to those who used the placebo. They experienced smoother skin, fewer wrinkles, improved texture, and a more even skin tone.
  2. Safety: The product was well-tolerated by participants, with no major side effects, making it a safe option for most people.

What This Means for You:

This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.

CLINICAL STUDY ►

Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

CLEAN BEAUTY

We have carefully formulated our products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.

Guarantees

MONEY BACK GUARANTEE

This product is qualified for the Money Back Guarantee.

Return Policy ►

 

FAQ's
No Questions

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.921772 / 5 from 5011 reviews.

AI Generated Review Summary

Summary topics

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Review highlights

Reviews

Undecided

"I honestly don't know if this works better than just my moisturizer and step 3. I use it as step 2 followed by another product from them (step 3) and a great moisturizer. No breakouts and my face does stays hydrated. The amount the pumos puts out is not much so you may need another 1/4-1/2 pump for face bringing down onto your neck. I have thin, drier skin and I'm mature and need hydration so I'll take what I can get."

— Marlene M. (4/5)

Biosil8

"I really like this serum texture. I have been using now for several weeks. I see a difference in overall texture and brightness. This was my first purchase with the moisturizer. I liked it very much so purchased at a great sale the splendor set of products which gives you most of their products to try."

— Bernie (5/5)

Eye radiance

"I like the weight of this eye cream. I use it twice daily The applicator feels nice and cool when applying. I don’t have a lot of wrinkles around my eyes. My problem is puffiness. Too soon to tell since it’s only been 3 weeks. Hope to see some decrease in puffiness."

— Bernie (4/5)

Masque

"This is a great exfoliant. I use twice a week. Leaves complexion soft clear without dryness I don’t know if I would call this a masque. Would love to see DefenAge develop a soothing hydrating masque"

— Bernie (5/5)

Excellent morning routine

"I have fortuitously been introduced to the Defenage line of products. So far I’ve tried and love the 8 in 1 Bioserum, the lip product and the 2 minute reveal. I like this company’s customer service and although it’s pricey I stick up during their great sales. I’m 61 and people say I look a lot younger. Using and buying these products reminds me to stay out of the sun."

— Joanne C. (5/5)

Excited for long-term results

"This lasted about about 9 weeks using liberally twice a day. My neck has been the area that's really started showing its age, and I can definitely tell an improvement after going through my first jar. My skin isn't as crepey and laxity has improved. I'm curious to see how continued use will affect skin my skin's quality and appearance. I just repurchased and plan to keep this in my routine for as long as I can afford it."

— Sal (4/5)

The only face wash I use

"I’ve bought this so many times I’ve lost count. It cleans thoroughly without my face feeling tight after and has great slip."

— Gia V. (5/5)

Calming complex

"I like the idea of what this can do. I don’t have redness or skin irritation per se but when I apply evenings my skin next morning appears to me to be clearer and just over all nicer. I like it."

— Bernie (4/5)

LOOKING GOOD

"I am very satisfied with the results of the revitalizing lip cream just as I am with every other Defenage product I use."

— Barb K. (5/5)

Love this!

"Hydrating, smooth finish, and clinical evidence to support! Will forever be in my lineup."

— Margaret H. (5/5)

Q&A

Is this the same grade of potency and quality as what is sold in a spa selling your product line?
We offer two different formulations of our line: • The PRO Exclusive line (with silver/platinum bottle) is not available on the internet and can only be purchased at an authorized medical or aesthetic practice. • With the PRO Exclusive line, we have taken our original purple formulas and enhanced them for maximum results. • The PRO Exclusive Line is more powerful due to the significant increase in our age-defying defensins, and should be used under the care of a medical professional. Please contact the med spa to purchase the PRO line or reach out to customerservice@defenage.com for further assistance.