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EYE AND LIP RENEWAL DUO
Lip Enhancer & Eye Cream
Ultimate care for delicate areas, visibly smooth and firm the skin around your eyes & lips
[ $180 value ]

2026 Holiday Promotion

30 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

Black Friday Promotion

Buy One, Get One 70% OFF

Add any 2 of the same item to your bag.

Discount applied automatically.

Black Friday countdown

Limited-time offer. While supplies last.

EYE AND LIP RENEWAL DUO

Lip Enhancer & Eye Cream
Ultimate care for delicate areas, visibly smooth and firm the skin around your eyes & lips
[ $180 value ]

2026 Holiday Promotion

30 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

Black Friday Promotion

Buy One, Get One 70% OFF

Add any 2 of the same item to your bag.

Discount applied automatically.

Black Friday countdown

Limited-time offer. While supplies last.

$126.00 Regular Price $180.00
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SKU
10995-m
  1. Value Bundle
  1. Fragrance Free
People en Español Star ProductNewBeautyBeautytap Award: Editor's PickSkincare Anarchy AwardEye Cream Award | NewBeauty Eye Cream Award

Brighten eyes and plump lips with DefenAge’s Eye & Lip Renewal Duo. Combining the powerful 3D Eye Radiance Cream and the breakthrough 12-Factor Revitalizing Lip Enhancer, this set smooths, firms, and revitalizes the look of these delicate areas, giving you a refreshed, youthful look.

Key Benefits:

  • • Eye Radiance: Helps to lift and firm the upper eyelids, reduces the appearance of dark circles, puffiness, and fine lines.
  • • Luscious Lips: Boosts collagen for fuller, firmer lips while deeply hydrating.
  • • Defensin-Loaded: Uses Defensins to regenerate skin look and help to improve texture without irritation.
  • • Gentle & Effective: Safe for sensitive skin, contact lens wearers, and all skin types.

Routine Contents:

  • • 12-Factor Revitalizing Lip Enhancer (Full Size, 0.25 fl. oz.)
  • • 3D Eye Radiance Cream (Full Size, 0.5 fl. oz.)

All products in this collection are supplied in original individual packaging.

Made in the U.S.A.

How To Use

DIRECTIONS

 

How to Use The 12-Factor Revitalizing Lip Enhancer

12-Factor Revitalizing Lip Enhancer Directions

1.

With the cap on, shake the bottle well before first use.

Take off the cap.

Step 1

2.

Apply once or twice daily. Hold the bottle at the indented areas with 2 fingers. Push down on both sides of the applicator to release a drop of the serum.

Step 2

3.

Use the tip of the applicator to smooth one pump over the lips.

Step 3

 

 

How to Use 3D Eye Radiance Cream

3D Eye Radiance Cream

3D Eye Radiance Cream

Daily: AM | PM

After cleansing, while the skin is still moist from rinsing, pump a drop of radiant under-eye treatment onto the applicator. Lightly dab three dots of dark circle eye cream above and below each eye. Using the applicator, massage cream around the eyes.
Suitable for all skin types.

 

 

WARNINGS

These products are for external use only. Keep out of your eyes. If the eye cream enters the eyes, rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

 

 

Clinical Studies

Study on Defensins and Skin Rejuvenation: What It Means for You

Background:

Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.

What are Defensins?

Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.

The Study:

  1. This was a double-blind, vehicle-controlled study, meaning neither the participants nor the researchers knew who was using the Defensin-containing product and who was using a placebo (vehicle).
  2. Participants included men and women with signs of skin aging, such as fine lines, wrinkles, uneven skin tone, and rough texture.
  3. They applied either the Defensin-containing product or a placebo product to their face for 6 weeks.

Key Results:

  1. Visible Improvement: Participants who used the Defensin-containing product showed significant improvement in skin quality compared to those who used the placebo. They experienced smoother skin, fewer wrinkles, improved texture, and a more even skin tone.
  2. Safety: The product was well-tolerated by participants, with no major side effects, making it a safe option for most people.

What This Means for You:

This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.

CLINICAL STUDY ►

Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

All formulas in this collection are fragrance-free.

CLEAN BEAUTY

We have carefully formulated our hand cream products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.

GREEN PLANET

The tubes and boxes are fully recyclable; please recycle.

Our products are not tested on animals.

Guarantees

MONEY BACK GUARANTEE

This product is qualified for the Money Back Guarantee.

In case of a refund, all products in this bundle should be returned.
Return Policy ►

 

FAQ's
What's included in the DefenAge Eye and Lip Renewal Duo?
The Eye and Lip Renewal Duo brings together the 12-Factor Revitalizing Lip Enhancer in the full size, 0.25 fl. oz., and the 3D Eye Radiance Cream in the full size, 0.5 fl. oz.
What are the key benefits of the Eye and Lip Renewal Duo?
The Eye and Lip Renewal Duo helps lift and firm the upper eyelids while reducing the look of dark circles, puffiness, and fine lines. Collagen support brings fuller, firmer lips with deep hydration, and Age-Repair Defensins work throughout to improve texture and skin renewal without irritation. Both formulas are gentle enough for sensitive skin, contact lens wearers, and all skin types.
How do I apply the 3D Eye Radiance Cream without irritating my eyes?
Gentleness is what matters most here. After cleansing, while skin is still moist, a pump of cream goes onto the metal applicator, dabbed in three small dots above and below each eye, then massaged in with the applicator itself rather than fingertips. Staying clear of the lash line and the eyes themselves prevents irritation, and if the cream does make contact with the eyes, rinsing thoroughly with water clears it right up.
Does the 3D Eye Radiance Cream reduce puffiness and dark circles?
Yes, reducing puffiness and fading the look of dark circles is exactly what the 3D Eye Radiance Cream is built for. A blend of antioxidants and soothing botanicals works alongside Age-Repair Defensins to visibly decrease puffiness and diminish discoloration, while also fading the appearance of crow's feet and fine lines around the eyes.
How does the 12-Factor Lip Enhancer hydrate lips?
Shea butter, panthenol, and hyaluronic acid work together in the 12-Factor Lip Enhancer to deliver deep, lasting hydration, softening the look and feel of dry or chapped lips. Age-Repair Defensins support the lips' natural renewal process alongside that hydration, building volume and firmness over time as moisture locks in.
How often should I use the Eye and Lip Renewal Duo?
Both the 3D Eye Radiance Cream and the 12-Factor Lip Enhancer fit into a twice-daily routine, morning and evening. Consistency drives results here, giving the Age-Repair Defensins in both formulas the best chance to work alongside skin's natural renewal process.
Is the Eye and Lip Renewal Duo safe for sensitive skin and contact lens wearers?
Both the 3D Eye Radiance Cream and the 12-Factor Lip Enhancer are formulated to work for all skin types, including sensitive skin. The eye cream is ophthalmologist and dermatologist tested safe for contact lens wearers, so both formulas fit comfortably into a daily routine without extra precautions.

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.913815 / 5 from 789 reviews.

AI Generated Review Summary

Summary topics

Review topics: ["results","feels","improvement","lips","looks","eyes","hydration","cream","value","lines","duo","lip renewal","difference","serum","applicator","defenage","bundle","set","moisturizer","use","works"].

Review highlights

Reviews

Eye radiance

"I like the weight of this eye cream. I use it twice daily The applicator feels nice and cool when applying. I don’t have a lot of wrinkles around my eyes. My problem is puffiness. Too soon to tell since it’s only been 3 weeks. Hope to see some decrease in puffiness."

— Bernie (4/5)

LOOKING GOOD

"I am very satisfied with the results of the revitalizing lip cream just as I am with every other Defenage product I use."

— Barb K. (5/5)

Required

"My lips struggle. I did three rounds of Accutane in my youth for acne and I don’t think my lips ever got back their ability to self-moisturize. On top of that, I’m a post-menopausal woman living in a very low humidity, high altitude area with many weather extremes. Plus my lips become easily sensitized to various irritants in lip products. Despite the steep price, this is the only product besides Vaseline I’m willing to buy over and over for my lips because it demonstrably helps improve their barrier function and reduces dryness and sensitivity. I do think it’s probably staving off lip lines too, but only time will tell. I highly recommend this as it’s become one of my Holy Grail products in recent years."

— Gillian (5/5)

Miracle eye and lip glow

"Both products make a difference in the texture and fine lines. You appear more hydrated and you do not notice the fine lines!"

— Helene B. (5/5)

Eye cream

"Good texture. No smells! Works well"

— Angela K. (5/5)

Decrease in fine lines

"Feels great, and looks as though there are less fine lines."

— Rachel S. (4/5)

Beautiful eye cream

"Goes on smooth, moisturizing, absolutely wonderful eye cream...love it!"

— deborah Z. (5/5)

Amazing eye cream!!

"I have terrible eyes always have, the applicator helps products go on smooth, hydrates eyes, I use an under eye color correcter after, product make it crappie!!"

— Julie H. (4/5)

It’s worth a try

"I like this but do find it a little pricey for the results that I see"

— Gia V. (4/5)

Less wrinkles and dryness

"Less wrinkles and dryness"

— Cathy L. (5/5)

Q&A