/ $165.00 with account /
FREE SHIPPING     1.0 fl. oz. | 30ml
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This remarkably smart 8-in-1 BioSerum seems to understand your skin’s needs better than your own DNA. Designed to activate, orchestrate and energize, this biologically-advanced anti aging cream like serum concentrate provides an unprecedented concentration of defensin molecules contained in the Age-Repair Defensin® Complex. Dermatologists and aesthetic professionals name defenins as a perfect retinol alternative and the 8-in-1 BioSerum as a retinol serum replacement. The best part? Results are equal to 8 separate serums. Apply with 24/7 Barrier Balance Cream to create smoother, younger looking skin. Patent-pending technology. Get the best skin ever today!


  • •  Rejuvenates smoothness.
  • •  Promotes radiance, revives skin’s natural moisture for ultimate glow.
  • •  Minimizes the look of fine lines, wrinkles and skin discolorations.
  • •  Brightens overall skin tone and clarity.
  • •  Renews the feel of skin firmness and elasticity.
  • •  Helps improve the appearance of skin redness.
  • •  Ideal for use around the delicate eye area.
  • •  Perfect to combine with microneedling or device treatment, contact us for microneedling protocol.


Starting out as a brand of an anti aging cream, 8-in-1 BioSerum (bio serum), DefenAge grew and expanded with a revolutionary portfolio of anti-aging skin care products. 8-in-1 BioSerum is DefenAge’s first and longest-produced product.



Add defensin-molecules to your skincare regimen!

Dermatologists agree, if you do one nice thing for your skin this year - introduce it to defensin-molecules. Defensins can be incorporated into your existing skincare regimen and do not conflict or compete with other skincare. Whether it’s CHANEL or Clinique, incorporating DefenAge + Defensins can actually enhance the skincare you already know and love.


Consumer survey says that 93% of consumers who use CHANEL skincare also like the results they see with DefenAge!

/ Survey 2019, data on file /


“Why do CHANEL users like DefenAge? – this is simple – DefenAge’s defensins multiply the effect of CHANEL, as well as other skincare. …Ironically, DefenAge skin care has no competition on the skincare market because it enhances any other skin care brands. Much like laser treatments and microneedling, the topical application of defensins causes our body to message ‘preserved,’ healthy cells to create visibly new skin. I recommend the BioSerum to my patients to activate their “skin’s memory”, triggering skin to look younger, twice a day – in the morning and evening by applying just one drop of DefenAge BioSerum over the moisturizer of their choice,”

-Board-certified dermatologist Natalie M. Curcio, M.D., M.P.H.


Check with us, what other skincare than CHANEL can be combined with DefenAge's defensins for more glowing skin.  


Made in the U.S.A.



8-in-1 BioSerum

STEP THREE | 8-in-1 BioSerum 

Daily: AM | PM

Place 1 pump of 8-in-1 BioSerum (bio serum) onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.

Suitable for all skin types.





For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 7 clinical studies.



The 8-in-1 BioSerum | Concept Anti Aging Cream was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.

Additional opthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.

The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.

All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.

We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile.  

Concept Ant-Aging Cream | 8-in-1 BioSerum




Age-Repair Defensins® | 5X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

Hyaluronic Acid | Low Molecular Weight

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


We have carefully formulated our products to exclude multiple harmful and questionable ingredients. 8-in-1 BioSerum (bio serum) DOES NOT contain: abrasives, aluminum salts, animal-derived ingredients, BPA, BHT/BHA, chemical sunscreens (oxybenzone, avobenzone, and octinoxate), coal tar, colorants, formaldehydes and formaldehyde-releasing agents, fragrance, gluten ingredients (no wheat, oats, barley), growth factors, human-derived ingredients, hydroquinone, irritating acids, mineral oil, oxybenzone, parabens, paraffin, petrolatum, phthalates, polyethylene and polypropylene (microbeads), propylene glycol, retinyl palmitate, sodium laureth sulfate (SLES), sodium lauryl sulfate (SLS), talc, toluene, triclocarban, triclosan, triethanolamine.


The bottle and box are fully recyclable, please recycle.

Not tested on animals.


8-in-1 BioSerum | Concept Anti Aging Cream

Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Sea Whip Extract, Ergothioneine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Offinalis (Rosemary) Leaf Extract, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Albumin, L-Alanyl-L-Glutamine, Caprylic/Capric Triglyceride, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride.
Fragrance free.

This product does not contain retinol and should not be considered as a retinol serum.



Quality guaranteed ONLY when 8-in-1 BioSerum is sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



8-in-1 BioSerum | Concept Anti Aging Cream (bio serum) is qualified for the Money Back Guarantee.
Return Policy ►


Why should the 8-in-1 BioSerum be layered last in a skincare routine?

The reason is because of a unique property of defensin molecules. Our bio serum contains DefenAge’s highest dose of defensins, which not only stimulate new skin, but also have shown to be effective in preventing water loss via the skin-surface’s natural “tight junction” mechanism. In other words, defensins “lock gaps” between surface cells; therefore water cannot go out, it is locked inside, but together with this – nothing goes in, meaning that if you apply any other creams or serums on top of the 8-in-1 BioSerum, their ingredients may not be absorbed.

We recommend that all skin care products in your routine be layered before the 8-in-1 BioSerum, only makeup and sunscreen should be layered on top in the morning, and nothing should be layered at night; please review the dermatologist recommendations on night skincare routines on our How-To Page.

My skin is glowing right after a week of the use of 8-in-1 BioSerum, can I increase the number of pumps for even more results?

Please be patient, more is not better. More results will not show up just because of an overuse of the bio serum. Concentrations of ingredients are very well balanced in the formula, please just follow with the recommended dosage and do it regularly: morning and night – results will not disappoint. Use one pump of the 8-in-1 BioSerum on the face and one on the neck. We also recommend exfoliating the skin regularly to see results faster – removing old cells from skin’s surface will unveil beautiful new skin; DefenAge’s gentle solution for exfoliation is the 2-Minute Reveal Masque.

Do I need to use a Vitamin C serum together with the Defensin anti-aging serum?

DefenAge’s 8-in-1 BioSerum contains a fine blend of naturally powerful anti-oxidants. We do not restrict DefenAge users form the using vitamin C serum, although we believe that it is unnecessary.

Is it true that makeup will be applied easier on skin treated with 8-in-1 BioSerum?

This is true. Due to the high concentration of defensin molecules, the skin will become smoother after using 8-in-1 BioSerum, therefore makeup will be applied easier than usual. Some consumers even say, “I do not need foundation after I started using DefenAge's bioserum.”

Why you call the 8-in-1 BioSerum an Anti-Aging Cream?

There are a few reasons. First of all, the 8-in-1 BioSerum is a perfect anti-aging cream that comprehensively addresses visible signs of skin aging on a global scale. Also, when we just built our brand and prepared to launch our products DefenAge had just one concept product, an anti-aging cream that was later named the 8-in-1 BioSerum. The 8-in-1 BioSerum is DefenAge’s concept anti-aging cream.

Is 8-in-1 BioSerum good for acne prone skin?

Yes it is. The 8-in-1 BioSerum is safe for acne prone skin, our bio serum underwent multiple safety studies that returned an outstanding safety profile. Please be sure that you use the exact quantity of the product that we recommended, and do not exceed it: 1 pump of the bio serum for entire face and 1 pump on the neck.