The Two-Step Routine With Results You Can See: 10 Reasons to Choose It
Anti-Aging Serum & Face MoisturizerVisibly rejuvenate skin, reduce the appearance of fine lines and wrinkles, boost hydration, and enhance radiance.
$22127% savings$304 if purchased separately.
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Discover Your New Skin
- Proprietary Age-Repair Defensins®
- U.S. Patents No. 11,491,096 & 11,020,452
- 4.9 stars from 2,726 reviews
- Free U.S. shipping
- 45-day money-back guarantee
- Fragrance free
- Made in the U.S.A.
Ten reasons to choose the Power Pair.
Two products, one simple and effective routine: hydrate with a moisturizer and renew with an anti-aging serum. Rated 4.9 stars from more than 2,700 reviews, the Power Pair works through your body’s own regenerative biology.
- 1A simple, effective two-step routine
- 2Unique patented mechanism, in both products
- 3Proven in a clinical study
- 4Results you can see, and others notice
- 5First results as soon as within the first week, the full range once you complete the bottles
- 6People like you love it
- 7Gentle, fragrance free, for all skin types
- 8Glowing and ready for Thanksgiving and the holiday season
- 9A perfect gift for someone you love, or yourself
- 1027% off for a limited holiday time
A simple, effective two-step routine.
- 1Hydrate24/7 Barrier Balance CreamDaily: AM | PM
After cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over the entire face.
- 2Renew8-in-1 BioSerumDaily: AM | PM
After applying the 24/7 Barrier Balance Cream, place 1 pump of 8-in-1 BioSerum onto fingertips. Lightly massage with fingertips first around the eyes, then over the entire face.
“Fantastic product. This has replaced the multiple other products that I was using previously. My skin is smooth and moisturized after using this.”
“I was concerned that the recommended 1 pump was not enough but surprisingly it provides full coverage and goes on very silky smooth.”
Unique patented mechanism, in both products.
“The skin hasn’t lost its ability to renew. It’s lost the signal to start.”
Dr. Jessica Weiser, dermatologist
- 1Your skin knows how to renewThis anti-aging routine works with your body’s own regenerative biology. Every time a small scratch heals, your skin makes new skin that looks younger than the skin around it, because your skin always knows how to renew. It just needs to get a signal. Defensins in DefenAge are that signal: they message your body through the same wound-healing biology, without a scratch.
- 2DefenAge brings the signal to your routinePatented Age-Repair Defensins® in 8-in-1 BioSerum and 24/7 Barrier Balance Cream are bio-synthesized copies identical to two human defensins. U.S. Patents No. 11,491,096 & 11,020,452.
- 3Your skin shows the renewalThe result is visible improvement across multiple signs of aging, as studied in a randomized, placebo-controlled clinical trial of a regimen that included both products.1
Proven in a clinical study.
In the published trial, 41- to 71-year-old women used a defensin-containing skincare regimen and their results were measured against a placebo.1 Its two core products, the 8-in-1 BioSerum and the 24/7 Barrier Balance Cream, make up the Power Pair.
“Globally improves the visual appearance of aging skin.”
“…offers most of the advantages of time-honored retinols without irritation, inflammation, or sun-sensitivity.”
Improvement in skin evenness, reduction in the appearance of visible pores, wrinkles, and pigmentation, plus normalization of skin oiliness.
Peer-reviewed and published in the Journal of Drugs in Dermatology. Read the study
5Significant improvement versus placebo simultaneously in 5 major signs of skin aging including the appearance of superficial and deep wrinkles, visible pores, pigmentation and epidermal quality.1
92%of customers experienced results2
“Defensins are the biggest breakthrough in skincare since the discovery of retinoids.”
“DefenAge results in profound improvements in the visible health and beauty of the skin that are readily apparent to even the untrained eye.”
“The defensin-based anti-aging technology is an authentic paradigm shift that I see only once per decade.”
Results you can see, and others notice.
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Baseline 4 weeks 
Baseline 12 weeks 
Baseline 7 months 
“Last night I played tennis against someone I’ve not seen for awhile and she kept telling me how young I looked. I’m 67…”
“The 8 in 1 serum is very effective. I have been getting compliments on my skin tone and condition since I started using the product 10 years ago. It was recommended by a dermatologist and from a plastic surgeon.”
First results as soon as within the first week, the full range of results once you complete the bottles.
Any scratch or cut on the skin heals within 7 days. That means your body can produce meaningful visible results within just 7 days.
DefenAge’s defensins use the same regeneration biology to visibly rejuvenate the skin.
Your first 6 weeks to renewed skin.
Discover what your skin can experience with the Power Pair, used as recommended.
From your very first application to the full range of visible results, explore how our patented Age-Repair Defensins® and the Power Pair help reveal smoother, firmer, more radiant-looking skin.
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Day 1
Your renewal begins.
Feel the difference
Your first step toward renewed skin starts today. Experience immediate hydration as your skin feels softer, smoother, and more comfortable.
What to look forSkin that feels hydrated, nourished, and refreshed.
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Day 3
The glow begins.
Your skin is getting started
As you continue your routine, your skin may begin to feel smoother, softer, and more supple. Your journey toward visible skin renewal is underway.
What to look forImproved softness, hydration, and a healthy-looking glow.
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Day 7
The first visible changes.
See the difference
Initial visible results may begin appearing after just one week. Look for improvements in skin texture, radiance, and overall appearance as your skin’s natural renewal process is supported.
What to look forSmoother-looking texture, improved radiance, and a more refreshed complexion.
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2 weeks
Your skin renewal journey.
Imagine what’s next
Two weeks into your DefenAge experience, you may begin noticing a smoother, more radiant-looking complexion. And this is just the beginning.
What to look forContinued improvements in the appearance of skin texture, softness, and radiance.
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4 weeks
Your results deepen.
Visible progress
After four weeks of consistent use, your skin may feel noticeably smoother and look more radiant, with a more even-looking tone. The appearance of fine lines and pores may look softer as your skin stays deeply hydrated and its natural barrier is supported.
What to look forSmoother texture, a luminous glow, a more even-looking tone, and softer-looking fine lines and pores.
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6 weeks
The full range of results.
Naturally, unmistakably glowing
At six weeks of use as recommended, you may experience the full range of visible improvements, including those measured in the published clinical trial.1 Deeply hydrated skin with a supported natural barrier glows, naturally and unmistakably.
What to look forVisibly healthier, rejuvenated skin. A softer appearance of fine lines, wrinkles, pores, and pigmentation. A brighter, clearer, more even tone with balanced oiliness. A renewed feeling of firmness and elasticity. Calmer-looking redness. A luminous glow that is unmistakably natural.
People like you love it.
97%would purchase DefenAge again2
94%are satisfied with their results2
“My skin looks and feels healthier than it has in years. That’s saying a lot for someone who is in her late sixties!”
“After using 8 in 1 and Barrier cream, my husband tells me my skin looks great! Love that : ). I’m a 68 yo.”
“I’m only 2 weeks in to the regime, but I’m already noticing my pores are smaller and I’ve had 2 compliments on my skin from friends that don’t know I’ve started using something new, so… EXCITED!!!”
“DefenAge addict. I am devoted to DefenAge products! Have been using it now for 4 years and get many compliments on my skin.”
DefenAge and the Power Pair products, awarded and featured by the most trusted beauty voices
Gentle, fragrance free, for all skin types.
Both the 8-in-1 BioSerum and the 24/7 Barrier Balance Cream are formulated to work for all skin types, from oily and combination to dry and sensitive, and both are fragrance free.
“You can’t even feel it when you’re wearing it.”
“not irritating like a retinol or acids.”
Glowing and ready for Thanksgiving gatherings and the holiday season.
Holiday tables, family photos and long-awaited reunions are full of close-up moments. With first results as soon as within the first week and the full range of results in 4 to 6 weeks, as used as recommended, your skin has time to look radiant for every gathering ahead.
Give your skin the time to shine this holiday season.
A perfect gift for someone you love, or for yourself.
- A 4 to 6-week supply8-in-1 BioSerum and 24/7 Barrier Balance Cream, 1.5 fl. oz. each.
- Fragrance free, for all skin typesEasy to choose for someone else, with no need to match scent or skin type.
- A routine anyone can followTwo steps after cleansing.
- Best-selling and dermatologist-recommendedTwo of DefenAge’s best-selling products, rated 4.9 stars from more than 2,700 reviews.
A gift of skincare works best when it is easy to use and easy to love. The Power Pair gives them two products and a simple routine.
“The Rolls Royce of skincare! Literally the best skincare products! I’ve seen such a huge difference in my natural glow!”
27% off for a limited holiday time.
The value is in the results.
Used as recommended, one bottle of each is enough to see the full range of results.
Power Pair
Anti-Aging Serum & Face Moisturizer · Fragrance Free
- 8-in-1 BioSerum1.5 fl. oz., 4 to 6-week supply
- 24/7 Barrier Balance Cream1.5 fl. oz., 4 to 6-week supply
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Free U.S. shipping · Made in the U.S.A.
We stand behind our products, and we are confident in their quality, performance and results. That is why your order is backed by our 45-day money-back guarantee.
“DefenAge has been a game changer in my practice. If I am going to choose one product, I will choose DefenAge.”
Before you decide.
What is in the Power Pair?
The 8-in-1 BioSerum and the 24/7 Barrier Balance Cream, 1.5 fl. oz. each, a 4 to 6-week supply.
How do I use the Power Pair?
After cleansing, apply up to 2 pumps of the 24/7 Barrier Balance Cream over the face while skin is still moist. Follow with 1 pump of the 8-in-1 BioSerum, applied around the eyes first and then over the face. Use both products twice daily, and follow with sunscreen in the morning.
Why does the 8-in-1 BioSerum go on after the 24/7 Barrier Balance Cream?
The 8-in-1 BioSerum contains the highest concentration of defensin molecules in any DefenAge formula. Defensins have a unique property of closing the gaps between skin cells, which effectively seals the skin’s surface and protects valuable moisture inside the skin. Applying the BioSerum last ensures the 24/7 Barrier Balance Cream is fully absorbed first, and that the defensins can work uninterrupted, particularly overnight.
What skin types is it for?
Both products suit all skin types, and both are fragrance free.
Can I use it with my current products?
Yes. After cleansing, apply any other treatments you already use. Then apply the 24/7 Barrier Balance Cream and the 8-in-1 BioSerum.
Has it been studied?
Both products were part of a defensin-containing regimen studied in a randomized, double-blind, placebo-controlled trial published in the Journal of Drugs in Dermatology (Taub et al., 2018). The regimen showed significant improvement versus placebo simultaneously in 5 major signs of skin aging, including superficial and deep wrinkles, visible pores, pigmentation and epidermal quality. See footnote 1 below.
How long does it last?
The Power Pair is a 4 to 6-week supply, enough to see the full range of results when used as recommended.
Your skin still knows how to renew. Give it the signal.
The Power Pair, backed by our 45-day money-back guarantee.
Discover Your New Skin1 Taub A, Bucay V, Keller G, et al. J Drugs Dermatol. 2018;17(4):426-441. Randomized, double-blind, placebo-controlled; three-product regimen of 8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque (an exfoliating mask to help you see results faster, available separately). Significant improvement versus placebo simultaneously in 5 major signs of skin aging, including the appearance of superficial and deep wrinkles, visible pores, pigmentation and epidermal quality. NCT02765763.
2 2022 DefenAge Consumer Satisfaction Survey (June 2022), existing customers, all DefenAge products. 92% experienced results (789 of 858 who answered); 94% are satisfied with their results (814 of 862); 97% would purchase again (840 of 862).