Seven Reasons to Consider the 8‑in‑1 BioSerum
Eight serums in one feather-light formula, built on proprietary Age-Repair Defensins®.
4.9 out of 5 from 1,587 reviews- Fragrance free
- Morning and night
- Suitable for all skin types
- Made in the U.S.A.
Free shipping on $60+ · 45-day money-back guarantee
“I really love not having so many bottles of product to apply twice daily and this serum ticks all the boxes and simplifies my routine!”
- Eight serums in one step
- Fragrance free
- Proprietary Age-Repair Defensins®
- U.S. Patent No. 11,491,096
- Morning and night
- Made in the U.S.A.
- 45-day money-back guarantee
- 4.9 stars from 1,587 reviews
Seven reasons to consider it.
DefenAge’s iconic Best Seller: eight serums in one step, built on proprietary Age-Repair Defensins®.
1Eight serums. One step.
Unlike traditional serums, our 8-in-1 BioSerum combines the benefits of eight specialized serums in one.
- Antioxidant SerumFor brighter-looking skin
- Niacinamide SerumFor a more even-looking tone
- Hyaluronic Acid (HA) SerumLow-weight HA for lasting hydration
- Collagen SerumSupports the look of firmness
- Calming SerumA blend of soothing botanicals
- Peptide SerumSmooths the look of wrinkles
- DNA-Repair Enzyme SerumA botanical enzyme complex
- Retinol-Alternative SerumAlpha-defensin 5 and beta-defensin 3
Key Performance Ingredients and Technologies
Proprietary Age-Repair Defensins® · U.S. Patent No. 11,491,096
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Age-Repair Defensins®
DefenAge’s Exclusive
Defensins are natural molecules. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.
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Niacinamide
hydration · firmness & elasticity · brightening
Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.
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Hyaluronic Acid
Low Molecular Weight · hydration
Promotes hydration and improves texture for remarkably smooth and even skin.
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Soothing and Calming Ingredients
skin calming & soothing
Extract from the flowers of ‘love in a puff’, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.
“This is a great product; replaces several things I would otherwise be using (so overall a better value and faster to apply)”
2Fragrance free, for all skin types.
The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it.
“My aesthetician recommended your products and I have been very pleased with the results. have very sensitive skin and have had no issues with the 8 in 1 bioserum.”
- Fragrance freeIn addition, this product does not contain fragrance.
- All skin typesSuitable for all skin types.
- Green planetThe bottle, box and package components are fully recyclable, please recycle.
- Not tested on animalsWe do not test products on animals.
Ingredient list
Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Octyldodecanol, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Rides Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Ergothioneine, Rosmarinus Officinalis (Rosemary) Leaf Extract, Helianthus Annuus (Sunflower) Seed Oil, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Tocopherol, Epigallocatechin Gallatyl Glucoside, Albumin, l-Alanyl-l-Glutamine, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride. Fragrance free.
3It addresses various visible signs of aging.
The 8-in-1 BioSerum transcends traditional skincare, unifying eight essential benefits for a youthful, radiant complexion.
“One of the few new skincare items I added to my routine last year and I definitely see an impact. Skin is smoother, a bit firmer and glowier. Happy to have discovered the 8-in-1 Bioserum!”
- Rejuvenating SmoothnessEnhancing visible skin health and quality.
- Reducing Signs of AgingMinimizing the look of fine lines, wrinkles, pores, and pigmentation.
- Promoting RadianceReviving skin’s natural moisture for a luminous glow.
- Brightening Skin ToneImproving overall clarity and luminosity.
- Renewing the Feeling of Firmness and ElasticityRestoring texture for a youthful feel.
- Calming RednessBeneficial for sensitive skin. Helps improve the appearance of skin redness.
4Three sizes: MEGA, 2 week supply and trial.
The MEGA bottle lasts about 8 weeks.
“I got a sample from the med spa and really liked the results I was getting so I purchased the full size.”
5BioSerum last: the final skincare step.
DefenAge follows a specific application order that differs from conventional skincare routines, and understanding why makes all the difference in results.
- 1CleanseCleanse morning and evening with your preferred cleanser or DefenAge’s 1-Step Multi-Cleanse.
- 2Any Other ProductsIf you use other skincare products, including vitamin C, retinols, or hyaluronic acid, apply them here.
- 3HydrateApply the 24/7 Barrier Balance Cream to the face, the 3D Eye Radiance Cream around the eyes, and the 6-Week Perfection Neck Tightening Cream to the neck. Wait 30 seconds.
- 47X Calming Complex (if using)Apply it after moisturizing and before the BioSerum.
- 5BioSerum LastApply the 8-in-1 BioSerum over the entire face, eyes, and neck as the final skincare step. In the morning, sunscreen and makeup can be applied on top. At night, nothing should be layered over the BioSerum.
Why does the BioSerum go on last?
The 8-in-1 BioSerum contains the highest concentration of defensin molecules in any DefenAge formula. Applying the BioSerum last ensures all other products are fully absorbed first, and that the defensins can work uninterrupted, particularly overnight.
“I've noticed a definite improvement in the overall appearance and feel of my skin since using the Defenage routine and the 8 in 1 Bioserum is the last item I add to seal it all in.”
6One pump for the face, one for the neck.
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1One pumpPlace 1 pump of 8-in-1 BioSerum onto fingertips.
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2Eyes, then face
Lightly massage with fingertips first around eyes, then over entire face.
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3Neck and décolleté
Use a second pump on neck and décolleté. Follow with sunscreen.
“I was concerned that the recommended 1 pump was not enough but surprisingly it provides full coverage and goes on very silky smooth.”
7Before you decide: product FAQs.
Customer service, for questions or a return: +1.888.368.5372 · CustomerService@DefenAge.com
Can I increase the number of pumps for even more results?
Please be patient, more is not better. More results will not show up just because of an overuse of the bio serum. Concentrations of ingredients are very well balanced in the formula, please just follow with the recommended dosage and do it regularly: morning and night. Use one pump of the 8-in-1 BioSerum on the face and one on the neck.
Does it contain retinol?
This product does not contain retinol and should not be considered as a retinol serum.
Do I need to use a Vitamin C serum together with the Defensin anti-aging serum?
DefenAge’s 8-in-1 BioSerum contains a fine blend of naturally powerful anti-oxidants. We do not restrict DefenAge users from using vitamin C serum, although we believe that it is unnecessary.
Is it true that makeup will be applied easier on skin treated with 8-in-1 BioSerum?
This is true. Due to the high concentration of defensin molecules, the skin will become smoother after using 8-in-1 BioSerum, therefore makeup will be applied easier than usual. Some consumers even say, “I do not need foundation after I started using DefenAge's bioserum.”
Is 8-in-1 BioSerum good for acne prone skin?
Yes it is. The 8-in-1 BioSerum is safe for acne prone skin, our bio serum underwent multiple safety studies that returned an outstanding safety profile. Please be sure that you use the exact quantity of the product that we recommended, and do not exceed it: 1 pump of the bio serum for entire face and 1 pump on the neck.
Is the 8-in-1 BioSerum covered by a guarantee?
8-in-1 BioSerum is qualified for the Money Back Guarantee. Quality guaranteed ONLY when 8-in-1 BioSerum is sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
“I tell everyone about the Defenafe serum. It is the best product I have used. It doesn't break me out, it works well under makeup, and it has transformed my skin.”
Awards for the 8-in-1 BioSerum
- 2026 Best of the YearAwarded to the 8-in-1 BioSerum
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Skincare Anarchy Award 2026Skincare: Serums. Also a Science of Skin 2025 Awards winner
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People en Español Star Product Hall of FameInducted into the first Hall of Fame, 2025
Skincare Anarchy Award 2026
People en Español Star Product Hall of Fame
A 4.9-Star Rating From Verified Buyers
- Fantastic product.
“Fantastic product. This has replaced the multiple other products that I was using previously. My skin is smooth and moisturized after using this.”
Ryan B.Verified Buyer - Yum
“The serum feels very silky and soothing on my skin. I’ve noticed a new radiance to my skin since I began using it.”
Leslie C.Verified Buyer - Great!
“Really love it! It fits so well with the cleanser and moisturizer - would definitely buy again! Not sure about full results yet as it's only been about a month, but it feels great!”
Shannon P.Verified Buyer - Amazing product
“This is one of the only products I continue to buy at this price point. It is amazing! Leaves my skin glowy and even.”
Geena C.Verified Buyer - 8-in-1 Buoserum
“Love the 8 in 1 Bioserum! I use it twice a day and really like how my skin feels and looks!”
Karen K.Verified Buyer - 8 - in- 1 Bioserum
“Love this product. I have been using for 5 years. I get many compliments on how good my skin looks. Highly recommend.”
Kari P.Verified Buyer
- Fragrance free
- Made in the U.S.A.
- 45-day money-back guarantee
- Free shipping on $60+
8-in-1 BioSerum
1.5 fl oz | 45ml | MEGA Size · Fragrance Free
DefenAge’s iconic Best Seller: eight serums in one step, built on proprietary Age-Repair Defensins®.
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Free standard shipping within the continental U.S. Quality guaranteed only when sold by defenage.com or authorized professionals.
Eight serums in one step, morning and night.
DefenAge’s iconic Best Seller, built on proprietary Age-Repair Defensins®.
Discover Your New Skin