New The complete DefenAge regimen in a two-week supply.
Gift Includes the DefenAge Signature Bag, our gift to you.
Welcome to DefenAge. The Renew & Reveal Discovery Collection is the easiest way to experience our complete core regimen. Inside, you'll find the DefenAge Core Age-Repair Regimen, the three-product system studied in a randomized, double-blind, placebo-controlled clinical trial, in a two-week supply, plus a full-size cleanser and our Signature Bag as a gift.
At the heart of the regimen is a beautifully simple idea: your skin already knows how to renew itself. Every time a small scratch heals, your skin relies on natural signals to renew, and defensins are part of that signal. DefenAge scientists found a way to bring that same signal into your daily skincare.
Meet Age-Repair Defensins®, the patented technology in 8-in-1 BioSerum and 24/7 Barrier Balance Cream. These bio-synthesized copies are identical to two human defensins, and they signal your skin's natural renewal process, which shows up as visible improvement across many signs of aging. Exclusive to DefenAge.
The Renew & Reveal Discovery Collection contains:
Fragrance-free. All cosmetic products are made in the U.S.A.
1 Taub AF, et al. J Drugs Dermatol. 2018. Randomized, double-blind, placebo-controlled; n=44 women; 12 weeks; three-product regimen of 8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque. NCT02765763.
2 2022 DefenAge customer satisfaction survey, n=874 existing customers, all DefenAge products.
Follow these steps morning and evening to get the most from your Renew & Reveal Discovery Collection.
Daily: AM | PM
Place a dime-size portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until a white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with a clean towel.
Suitable for all skin types.
After STEP ONE
Once or twice a week after cleansing, dry skin thoroughly. Apply a quarter-size dollop of masque to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less, depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream).
Not recommended for acne, extremely sensitive or abraded skin.
Daily: AM | PM
Twice daily after cleansing, place a pea-size amount of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
Daily: AM | PM
Apply after 24/7 Barrier Balance Cream.
30 seconds after applying STEP TWO, place a pea-size amount of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second drop on neck and décolleté. In the morning, follow with sunscreen.
Suitable for all skin types.
Two weeks is the start of your regimen, and visible results build with consistent use. The full-size DefenAge core age-repair regimen continues the same three-product system studied in the clinical trial.
The DefenAge Core Age-Repair Regimen in this collection has been studied through early clinical pilots, a randomized, placebo-controlled trial, and further peer-reviewed research.
"Globally improves the visual appearance of aging skin."
That was the conclusion of a 12-week clinical study published in the Journal of Drugs in Dermatology. 44 women used either the three-product DefenAge regimen (8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque) or placebo formulas.
Significant improvement versus placebo in the look of:
Taub A, Bucay V, Keller G, Williams J, Mehregan D. Journal of Drugs in Dermatology. 2018;17(4):426-441. ClinicalTrials.gov NCT02765763.
Up to 18 years (±4) younger-looking skin
Before the clinical trial, early formulas of the same three-product regimen were tested in two 6-week pilot studies at a Santa Barbara plastic surgery practice, using QuantifiCare skin imaging and unretouched photos.
Keller G, pilot studies, 2014–2015. Unpublished; small samples (open-label: n=10; double-blind: 5 active vs 5 placebo); early regimen formulas; QuantifiCare visible skin-age analysis based on skin evenness, group averages. Individual results vary.
80% rated improved or much improved
In a second study published in the Journal of Drugs in Dermatology, 20 adults ages 45 to 80 used a five-product DefenAge regimen for three months. Investigators at two centers assessed the eye area at 30, 60 and 90 days.
Hartman et al. Journal of Drugs in Dermatology. 2023. Two-center, open-label; n=20, ages 45–80; periocular assessment. Five-product DefenAge regimen that included 8-in-1 BioSerum and 24/7 Barrier Balance Cream. ClinicalTrials.gov NCT05082766.
2022 DefenAge customer satisfaction survey, n=874 existing customers, all DefenAge products.
DefenAge formulas are dermatologist tested, and 8-in-1 BioSerum is also ophthalmologist tested.
In 8-in-1 BioSerum and 24/7 Barrier Balance Cream
Defensins are molecules your body already makes. Age-Repair Defensins® are bio-synthesized copies identical to two human defensins, α-defensin 5 and β-defensin 3, and they signal the skin's natural renewal process, which shows up as visible improvement across many signs of aging. Age-Repair Defensins® are exclusive to DefenAge and covered by U.S. Patents No. 11,491,096 and 11,020,452.
In [confirm products]
Helps skin feel soothed and hydrated, supports the look of firmness and elasticity, and brightens the look of overall skin tone.
Replenishes hydration for skin that looks and feels remarkably smooth and even.
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A concentrated blend of calming botanicals, including love-in-a-puff flower extract, Epigallocatechin Gallatyl Glucoside (a water-soluble form of one of green tea's key molecules) and black currant seed extract, helps skin feel calm and comfortable.
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Our know-how-protected blends of antioxidants and enzymes help defend skin against free radicals and environmental stressors, for a clearer, revitalized, luminous look.
In 2-Minute Reveal Masque
Fine crystals gently exfoliate dull surface buildup, then dissolve as you massage, revealing smoother, fresher-looking skin.
In 1-Step Multi-Cleanse
Prebiotics help maintain the skin's natural balance while you cleanse, leaving skin feeling comfortable and refreshed.
In 1-Step Multi-Cleanse
Cleanses thoroughly while helping skin keep its natural moisture balance. Leaves skin feeling soft and hydrated.
DefenAge created its own standards for clean skincare, which match or exceed skincare industry practices. Every formula in this collection meets them. Explore the full list of restricted ingredients and our clean-beauty principles on our Clean Beauty page.
The tubes and box are fully recyclable. Please recycle.
Not tested on animals.
Detailed ingredient lists for every formula in this collection can be found on the individual product pages:
For external use only. Keep out of eyes. If product enters eyes, rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.
This skincare travel kit is qualified for the Money-Back Guarantee.
New The complete DefenAge regimen in a two-week supply.
Gift Includes the DefenAge Signature Bag, our gift to you.