Loading...
2026 Best Of The Year Award: DefenAge 8-in-1 BioSerum
NEW: Meet Hydration+ | An Extra Level of Hydration | SHOP NOW
Not sure where to start?
Take the quiz and we'll build a regimen made just for you.
Build Your Regimen
2026 Best Of The Year Award: DefenAge 8-in-1 BioSerum
https://defenage.com/24-7-barrier-balance-cream-hydration-plus.html
Not sure where to start?
Take the quiz and we'll build a regimen made just for you.
Build Your Regimen
Set Descending Direction
  1. Splendor All-In-One Collection
    46% Savings
    SPLENDOR ALL-IN-ONE COLLECTION

    2026 Holiday Promotion
    Our Best Collection Discount Ever!
    The epitome of visible results paired with an elegant, satisfying experience. Explore our ultimate collection, featuring every one of our award-winning skincare products.
    50% SAVINGS over buying individually!

    $572.00 Regular Price $1,144.00
  2. FLAWLESS FACE COLLECTION
    Limited Time
    FLAWLESS FACE COLLECTION

    2026 Holiday Promotion
    A comprehensive facial care collection designed to hydrate, protect, and rejuvenate for luminous, youthful-looking skin. 
    40% SAVINGS over buying individually!

    $466.00 Regular Price $778.00
  3. DefenAge Power Pair: Anti-Aging Serum & Face Moisturizer
    Limited Time
    POWER PAIR

    2026 Holiday Promotion
    Anti-Aging Serum & Face Moisturizer
    Legacy Formulation

    Visibly rejuvenate skin, reduce the appearance of fine lines and wrinkles, boost hydration, and enhance radiance.
    27% SAVINGS over buying individually!

    $221.00 Regular Price $304.00
  4. DefenAge Power Pair: Anti-Aging Serum & Face Moisturizer
    LIMITED TIME
    POWER PAIR - HYDRATION+

    2026 Holiday Promotion
    Anti-Aging Serum & Face Moisturizer
    Hydration+ Edition

    Visibly smooth signs of aging, boost hydration, and support a stronger, healthier-looking skin barrier.
    27% SAVINGS over buying individually!

    $221.00 Regular Price $304.00
  5. DefenAge Power Pair: Anti-Aging Serum & Men's Face Moisturizer
    LIMITED TIME
    POWER PAIR - MENS EDITION

    2026 Holiday Promotion
    Anti-Aging Serum & Face Moisturizer
    Men's Edition

    Visibly energize skin, reduce the appearance of fine lines and wrinkles, and boost hydration.
    27% SAVINGS over buying individually!

    $221.00 Regular Price $304.00
  6. Eye-conic Duo | 8-in-1 BioSerum, 3D Radiance Eye Cream
    LIMITED TIME
    EYE-CONIC PAIR

    2026 Holiday Promotion
    Anti-Aging Serum & Eye Cream
    Visibly brighten tired-looking eyes, reduce the appearance of fine lines and wrinkles, and boost hydration.
    27% SAVINGS over buying individually!

    $221.00 Regular Price $304.00
  7. Eye & Lip Renewal Duo: Lip Enhancer & Eye Cream
    LIMITED TIME
    EYE AND LIP RENEWAL DUO

    2026 Holiday Promotion
    Lip Enhancer & Eye Cream
    Ultimate care for delicate areas, visibly smooths and firms the skin around the eyes & lips.
    30% SAVINGS over buying individually!

    $126.00 Regular Price $180.00
  8. Smooth & Sculpt Neck Set: Neck Cream & Masque | 2026 Winter Collection
    LIMITED TIME
    SMOOTH AND SCULPT NECK SET

    2026 Holiday Promotion
    Neck Cream & Masque
    Visibly lift, tighten, and smooth the neck & décolletage to restore a youthful appearance.
    30% SAVINGS over buying individually!

    $117.00 Regular Price $168.00
  9. 8-in-1 BioSerum Anti Aging Cream, 1.5 fl oz / 45 ml / Mega Size
    #1 Seller
    8-IN-1 BIOSERUM

    An innovative, anti-aging serum bringing together 8 specialized serums in one.

    $198.00
  10. 24/7 BARRIER BALANCE CREAM - HYDRATION+
Advanced hydration, barrier support, and Defensin-powered age repair for skin that wants more moisture and comfort.
    2026 NEW
    24/7 BARRIER BALANCE CREAM - HYDRATION+

    Advanced hydration, barrier support, and Defensin-powered age repair for skin that wants more moisture and comfort.

    $106.00
  11. Morning & Night Skincare Routine
    25% SAVINGS
    MORNING AND NIGHT ROUTINE

    A comprehensive morning & night skincare set to promote overall skin heath.

    $426.00 Regular Price $568.00
  12. Dermatologist Recommended Skin Care Clinical Power Trio - Fragrance Free
    CLINICAL POWER TRIO

    DefenAge's signature dermatologist recommended skin care treatment.

    $328.00
  13. 24/7 Barrier Balance Age-Repair Cream | Fragrance Free | DefenAge® | The Best New Skin Care for Skin Rejuvenation
    24/7 BARRIER BALANCE ANTI-AGING CREAM

    An intense hydrating, barrier cream infused with Age-Repair Defensins® technology.

    $106.00
  14. 3D Eye Radiance Cream | Lifts & Firms Eye Area | DefenAge® Beauty Brand | Award Winning Skin Care Product for Eyes
    3D EYE RADIANCE CREAM

    An illuminating eye cream infused with breakthrough Age-Repair Defensin® technology.

    $106.00
  15. Fragrance-free neck tightening cream by DefenAge designed to firm sagging skin and improve neck elasticity in 6 weeks
    6-WEEK PERFECTION NECK TIGHTENING CREAM

    A luxe anti-aging neck cream infused with leading age-repair technology.

    $106.00
  16. 12-Factor Revitalizing Lip Enhancer | Lip Gloss & Lip Plumper for Smoker's Lines
    12-FACTOR REVITALIZING LIP ENHANCER

    The complete lip care solution: visibly smooths, plumps, hydrates, and protects lips.

    $74.00
  17. 7X Calming Complex
    7X CALMING COMPLEX

    A boosting treatment to defend your skin against hidden inflammation that accelerates aging.

    $74.00
  18. 10 Luxe Hand & Body Cream
    NEW 2.5X BIGGER
    10 LUXE HAND AND BODY CREAM

    A deeply hydrating, firming anti-aging lotion for hands and body.

    $168.00
  19. 360-Rejuvenation Nail Root Serum
    360-REJUVENATION NAIL ROOT SERUM

    A defensin-powered nail serum that promotes stronger, smoother, healthier nails and cuticles.

    $92.00
  20. DefenAge 2-Minute masque for refreshing tired skin and improving texture in minutes, fragrance-free
    2-MINUTE REVEAL MASQUE

    A gentle, exfoliating face mask designed to reveal fresher, youthful-looking skin.

    $62.00
  21. DefenAge's 1-Step Multi-Cleanse facial cleanser that removes makeup using natural prebiotics without drying skin
    1-STEP MULTI-CLEANSE

    A luxurious, hydrating facial cleanser with natural prebiotics to melt away debris.

    $52.00
  22. Morning Skincare Routine
    21% SAVINGS
    MORNING ROUTINE

    A complete morning routine that replenishes moisture and boosts glow.

    $364.00 Regular Price $462.00
  23. Nighttime Skincare Routine
    21% SAVINGS
    NIGHTTIME ROUTINE

    Nighttime routine that repairs daily damage and promotes natural skin renewal.

    $364.00 Regular Price $462.00
  24. Ultra Neck Perfection Treatment | NewBeauty Award Bundle | Email exclusive
    21% SAVINGS
    ULTRA NECK PERFECTION TREATMENT

    Complete skincare set for the neck and décolletage, where aging shows most.

    $282.00 Regular Price $356.00
  25. Ultimate Hand Trio with the Nail Serum| DefenAge
    HAND CARE ROUTINE

    Cosmetic hand treatment kit that reverses signs of skin aging and sun damage.

    $390.00 Regular Price $520.00
  26. Wedding Prep Skincare Routine
    22% SAVINGS
    WEDDING PREP ROUTINE

    A high-performing collection to relieve stressed skin and promote renewed skin cells.

    $370.00 Regular Price $472.00
  27. Fly Kit | Serum, Mask, Cream | Fragrance Free | DefenAge® Skincare | Two Week Trial Size | The Best New Skin Care
    FLY KIT

    A travel-size of the Clinical Power Trio, DefenAge's core regimen. Cosmetic bag included.

    $98.00
  28. DefenAge's fragrance-free skincare starter set with serum, cream, and masque for firmer, more radiant skin in 24 hours
    24-HOUR FAST STARTER KIT

    A trial size of the Clinical Power Trio, DefenAge's signature regimen.

    $19.00
  29. DefenAge Minis
    43% Savings
    DEFENAGE DISCOVERY MINIS

    An all-inclusive trial-size, luxury skincare regimen for the face and body.

    $48.00 Regular Price $86.00
  30. DefenAge'a 150K Follicle serum for thinning hair to invigorate scalp and improve hair density
    150K HAIR FOLLICLE SERUM

    A super-charged scalp serum designed to help hair follicles flourish.

    $106.00
  31. Men's Skin Booster
    25% SAVINGS
    MENS SKIN BOOSTER

    A complete skin booster treatment tailored for men's skin needs.

    $178.00 Regular Price $239.00
  32. Men's Skin Provision | Best Breakthrough Product Award
    25% SAVINGS
    MENS SKIN PROVISION

    A scientifically proven, easy-to-use daily skincare system tailored for men’s skin.

    $118.00 Regular Price $158.00
  33. 24/7 Barrier Balance Cream - Men's Edition
    24/7 BARRIER BALANCE CREAM - MENS EDITION

    A clinically backed anti-aging barrier cream tailored to the unique needs of men's skin.

    $106.00
  34. 150K Hair Follicle Serum | Visible Rejuvenation | Best Hair Growth Serum Awards | Men's Edition
    150K HAIR FOLLICLE SERUM - MENS EDITION

    A revitalizing scalp and beard serum that helps to stimulate stronger, fuller hair.

    $106.00
  35. 100% Silk Pillowcase | Mulberry Silk Pillowcase | A Silk Pillowcase Skin Care Regimen | DefenAge® Beauty Brand
    100% SILK PILLOWCASE

    A mulberry silk pillowcase designed for luxurious sleep and beauty benefits.

    $98.00
    Out of stock
  36. e-Gift Card | DefenAge® Skincare
    e-Gift Card

    Give the gift of DefenAge to your friends and family!

    From $20.00
Set Descending Direction