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4.9 out of 5 from 3,410 reviews

Discovery Kit: The Two-Week Defensin Experience

DefenAge Discovery Kit: the three trial-size tubes in front of the purple cosmetic bag

DefenAge's three-step regimen in trial sizes: two weeks with proprietary Age-Repair Defensins®.

$29$98 valueSave 70%

One-time introductory offer. You save $69.

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Free shipping. No subscription. 45-day guarantee.

  • $29 introductory price ($98 value)
  • No subscription required
  • Free shipping
  • 45-day money-back guarantee
  • Proprietary Age-Repair Defensins®
  • U.S. Patents No. 11,491,096 and 11,020,452

For the skin you have now, and the routine you want.

A woman smiling in the sun, holding a bottle of 8-in-1 BioSerum
  1. You're curious about DefensinsYou have read about Age-Repair Defensins® and want to see them on your own skin before you buy full size.
  2. Your shelf is crowdedYou would rather keep one simple routine: three products, a few minutes, morning and evening.
  3. You want a retinol alternativeDermatologists recommend DefenAge as one. The study on this regimen found most of retinol's advantages without the irritation or sun sensitivity.
  4. Your routine isn't deliveringYou're ready to discover a new skincare solution because your current routine isn't delivering the results you want.
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Your day, in order.

Three products, a few minutes, morning and evening. Keep the cleanser and sunscreen you already use.

A woman in a white robe at the bathroom mirror, pressing cream into her cheeks
Cream first, then serum. Masque 1-2 times per week.
  1. 1

    Your cleanserKeep the one you use now.

  2. 2

    24/7 Barrier Balance CreamA pea-size amount over the face while skin is still damp.

  3. Wait 30 seconds

  4. 3

    8-in-1 BioSerumAround the eyes and over the face.

  5. 4

    Your sunscreenAlways last in the morning.

Morning and evening, every day. The masque once or twice a week. All three are fragrance free.

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Your first 14 days to renewed skin.

Discover what your skin can experience with DefenAge.

From your very first application to the first signs of visible renewal, explore how our patented Age-Repair Defensins® and Clinical Power Trio help reveal smoother, firmer, more radiant-looking skin.

  1. Day 1

    Your renewal begins.

    Feel the difference

    Your first step toward renewed skin starts today. Experience immediate hydration as your skin feels softer, smoother, and more comfortable.

    What to look forSkin that feels hydrated, nourished, and refreshed.

  2. Day 3

    The glow begins.

    Your skin is getting started

    As you continue your routine, your skin may begin to feel smoother, softer, and more supple. Your journey toward visible skin renewal is underway.

    What to look forImproved softness, hydration, and a healthy-looking glow.

  3. Day 7

    The first visible changes.

    See the difference

    Initial visible results may begin appearing after just one week. Look for improvements in skin texture, radiance, and overall appearance as your skin's natural renewal process is supported.

    What to look forSmoother-looking texture, improved radiance, and a more refreshed complexion.

  4. Day 14

    Your skin renewal journey.

    Imagine what's next

    Two weeks into your DefenAge experience, you may begin noticing a smoother, more radiant-looking complexion. And this is just the beginning.

    What to look forContinued improvements in the appearance of skin texture, softness, and radiance.

Beyond day 14: the best is yet to come.Your Discovery Kit is just the introduction. Continue your DefenAge routine to experience the full range of visible improvements in as little as six weeks, including the appearance of fine lines, wrinkles, firmness, and skin texture.

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Your skin is more capable than your skincare.

Illustration of Defensins reaching the renewal cells in the skin's lower layers

Your skin holds a reserve of dormant cells, younger and less damaged than the ones on the surface. They have always been there. Age-Repair Defensins® signal those dormant cells to become active, the same biological pathway the body uses during wound healing. No injury required.

The skin has not lost its ability to renew; what quiets with age is the signal to start. DefenAge is the only skincare line built on proprietary Age-Repair Defensins® (U.S. Patents No. 11,491,096 and 11,020,452), developed with board-certified dermatologists and made in the U.S.A.

44Women aged 41 to 71 in the published double-blind, placebo-controlled study of this regimen

28Awards from the most trusted voices in beauty

10,000+Five-star reviews from verified buyers across DefenAge

The same three steps, in a clinical study.

The full-size version of the Discovery Kit was tested against placebo in a multi-center, double-blind study across three U.S. clinics, peer-reviewed in the Journal of Drugs in Dermatology, 2018.

Study participant before and after on the full-size regimen, side profile
Global skin improvementParticipant 10 on the full-size regimen. Photos not retouched.
Clinical imaging of visible pores, before and after, with the pore areas highlighted
Visible poresBefore and after. Areas associated with visible pores are highlighted using a clinical imaging system.
Clinical imaging of visible wrinkles, before and after, with the wrinkle areas highlighted
Visible wrinklesBefore and after. Areas associated with visible wrinkles are highlighted using a clinical imaging system.

A. Taub, V. Bucay, G. Keller et al. J Drugs Dermatol. 2018, 17(4):426-441. The regimen “globally improves the visual appearance of aging skin” and offers “most of the advantages of time-honored retinols… without irritation or inflammation, sun-sensitivity.”

“The skin hasn't lost its ability to renew. It's lost the signal to start. That changes the whole conversation about what we should be reaching for.”
Dr. Jessica Weiser, board-certified dermatologist, Weiser Skin MD, New York
“DefenAge really represents a major advanced paradigm shift seen once per decade. The science is remarkable.”
Amy Forman Taub, MD, FAADDermatologist
“I believe that DefenAge is the next biggest game-changer in topical products for anti-aging.”
Angela Bowers, MDDermatologist
“DefenAge has been a game changer in my practice. If I am going to choose one product, I will choose DefenAge.”
Steven L. Swengel, MDDermatologist

Every formula in the kit is dermatologist tested. The 8-in-1 BioSerum is also ophthalmologist tested and safe for contact lens wearers.

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Keep what works. Add what's missing.

  • Keep your cleanser and sunscreenThe cream goes on after cleansing, the serum follows, and your sunscreen goes on last in the morning.
  • Suitable for all skin typesThe 24/7 Barrier Balance Cream and the 8-in-1 BioSerum are made for every skin type.
  • No fragrance addedAll three Discovery Kit formulas are fragrance free.
  • Dermatologist testedEvery formula in the kit. The 8-in-1 BioSerum is also ophthalmologist tested and safe for contact lens wearers.
  • Clean beautyDiscover science-backed formulas developed with skin health in mind. All three products are fragrance-free and never tested on animals.
  • Made in the U.S.A.Covered by U.S. Patents No. 11,491,096 and 11,020,452.

Enjoy the 2-Minute Reveal Masque once or twice weekly as part of your skincare ritual. Not recommended for acne-prone, extremely sensitive, or abraded skin.

Your two weeks start here.

DefenAge Discovery Kit: the three trial-size tubes in front of the purple cosmetic bag

4.9 · 3,410 reviews

Discovery Kit

Two-week supply · Trial sizes · Fragrance free

A two-week introduction to proprietary Age-Repair Defensins®: the full three-step regimen in trial sizes.

  • 8-in-1 BioSerum

    0.33 fl oz
  • 24/7 Barrier Balance Cream

    0.5 fl oz
  • 2-Minute Reveal Masque

    net wt. 0.75 oz
  • DefenAge cosmetic bag

    Free gift
One-time introductory offer

$29$98

About $2.07 a day$98 value

You save $69, 70% off the $98 value.

Free shipping · No subscription · 45-day money-back guarantee

Available while supplies last.

After you order.

  1. Order todayFree shipping, no subscription, nothing renews.
  2. Two weeks, three stepsFollow the routine above, morning and evening, and watch for each milestone.
  3. The next step is yoursGo full size if you love it. If not, the 45-day money-back guarantee has you covered.

What people notice first.

4.9 out of 5 from 3,410 reviews of the Clinical Power Trio, the full-size regimen in the Discovery Kit

“Great starter! Bought this to try the product before purchasing full size. Skin improved in the first week of using the products as instructed. Have now purchased the entire collection to try.”
Denise, Verified Buyer
“The Rolls Royce of skincare! Literally the best skincare products! I've seen such a huge difference in my natural glow!”
Jessica G., Verified Buyer
“DefenAge addict. I am devoted to DefenAge products! Have been using it now for 4 years and get many compliments on my skin.”
Martha F., Verified Buyer
“The best and only products I use!!! I have been using DefenAge products for several years and I love my 67 year old skin! The system is fast, easy and helps keep my skin looking healthy and youthful.”
Joan, Verified Buyer

As featured in

Before you start.

Still unsure? Call +1.888.368.5372 or write to CustomerService@DefenAge.com.

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What is in the Discovery Kit?

The trial-size Clinical Power Trio: 8-in-1 BioSerum (0.33 fl oz), 24/7 Barrier Balance Cream (0.5 fl oz) and 2-Minute Reveal Masque (net wt. 0.75 oz), with DefenAge's signature cosmetic bag as a free gift. All three formulas are fragrance free.

How long does it last?

Two weeks, used as directed: cream and serum morning and evening, the masque once or twice a week.

Is this a subscription?

No. $29 is a one-time introductory price for one kit, with free shipping. Nothing renews and there is nothing to cancel.

When will I see results?

Initial visible results may begin appearing after just one week, and two weeks in you may begin noticing a smoother, more radiant-looking complexion. Continue your DefenAge routine to experience the full range of visible improvements in as little as six weeks.

Can I use it with my current skincare?

Yes. Keep your cleanser and your sunscreen. After cleansing, apply the cream, wait 30 seconds, then the serum; in the morning, follow with sunscreen. On masque days, use it after cleansing and before the cream.

Is it suitable for sensitive skin?

The cream and serum are suitable for all skin types, and all three formulas are dermatologist tested with no fragrance added. The masque is not recommended for acne-prone, extremely sensitive, or abraded skin. If irritation develops, stop and consult a physician.

What if it's not for me?

The Discovery Kit qualifies for DefenAge's 45-day money-back guarantee. Call +1.888.368.5372 or email CustomerService@DefenAge.com to start a return.

How is it different from the Clinical Power Trio?

Same three products, same formulas, in trial sizes for two weeks. The full-size Clinical Power Trio lasts 4 to 8 weeks, long enough to see the full range of results.

Two weeks. Three steps. An easy decision.

$29 today, regularly $98. Free shipping, no subscription, and a 45-day money-back guarantee.

Try now

One-time introductory offer. Available while supplies last.