Great product
"I bought one product and then wanted to try more because I liked the serum so much."
A complete winter barrier skin repair system to calm, strengthen, and defend against visible signs of aging.
30 % SAVINGS compared to purchasing individually
Limited-time offer. While supplies last.




Your skin barrier is your first line of defense—essential for locking in moisture, defending against irritants, and playing a critical role in maintaining barrier strength and overall skin health. During winter weather, the cold temperatures and dry air can severely weaken this protective layer. When compromised, the skin may become dry, reactive, inflamed, and prone to accelerated signs of aging.
The Barrier Repair Kit is a targeted, three-step system designed to help calm winter-stressed skin and support long-term barrier health.
All products in this collection are supplied in original individual packaging.
Made in the USA.
Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area.
Suitable for all skin types.
We recommend using the 7X Calming Complex in full for 10–14 days. Apply a pea-sized amount of serum to your fingertips and gently massage onto the face using light, upward motions. For the neck and décolleté, dispense an additional drop and smooth evenly. Use after your daily moisturizer and before applying the 8-in-1 BioSerum. Suitable for all skin types. This cosmetic treatment can be repeated 4–6 times per year to help calm, restore, and maintain balanced skin.
Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly.
Not recommended for acne, extremely sensitive or abraded skin.
For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.
Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.
Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.
This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.
Please review the key performance ingredients and detailed ingredient lists on the individual product pages:
We have carefully formulated our products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.
Quality guaranteed ONLY when items are sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources.
A complete winter barrier skin repair system to calm, strengthen, and defend against visible signs of aging.
30 % SAVINGS compared to purchasing individually
Limited-time offer. While supplies last.