Advanced hydration, barrier support, and Defensin-powered age repair for skin that wants more moisture and comfort.
New An extra level of hydration.
The newest addition to the 24/7 Barrier Balance Cream Family - Hydration+ was created for skin that wants an extra level of hydration and comfort.
Powered by Age-Repair Defensins®, Hydration+ supports skin's natural renewal process to promote fresh, healthy-looking skin and improve the visible signs of aging over time. An advanced, multi-level hydration and barrier-support system replenishes moisture, helps skin retain hydration and promotes lasting comfort.
Good For Skin Experiencing
Not sure which 24/7 Barrier Balance Cream formula is right for you?
Both formulas provide daily hydration, barrier support and DefenAge's proprietary Age-Repair Defensins®. Choose the level of hydration and comfort that best suits your skin.
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24/7 Barrier Balance Cream
Legacy Formula
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24/7 Barrier Balance Cream
Hydration+
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| Hydration Level | Balanced everyday hydration | Enhanced hydration + comfort |
| Best For | Balanced everyday hydration | Skin wanting additional hydration and comfort |
| Moisture Feel | Balanced daily moisture | Cushioned, replenishing moisture |
| Finish | Natural | Smooth, refined matte |
| Age-Repair Defensins® | ✓ | ✓ |
| Barrier Support | ✓ | ✓ |
| Enhanced Hydration | — | ✓ |
Find Your 24/7 Match
Answer a few quick questions about your skin and daily routine to discover which formula suits you best. As your skin's needs change with the seasons or travel, you may find a place for both in your routine.
Take the 24/7 Quiz →Â
Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. Lightly massage with fingertips over entire face. For better results, apply after showering or bathing.
Suitable for all skin types.
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For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.
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DefenAge is proven in more than 30 clinical studies. All DefenAge formulas are dermatologist tested.
Multi-center, placebo-controlled, double-blind, clinical study shows that DefenAge’s core regimen, “globally improves the visual appearance of aging skin... without irritation or inflammation, or sun-sensitivity.”
Journal of Drugs in Dermatology 2018, 17(4): p. 426-441Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD
DefenAge's proprietary technology supports the skin's natural renewal process, helping promote fresh, healthy-looking skin and improve the visible signs of aging over time.
Supports Natural Moisturizing Factors and epidermal lipid organization to help skin maintain healthy hydration and limit moisture loss.
A biotechnology-derived complex that supports moisturization, skin resilience and cohesion for a smoother, more comfortable feel.
Targeted peptides support skin cohesion and resilience, complementing the formula's multi-level approach to moisture-barrier care.
Skin-replenishing lipids help condition, soften and cushion skin while supporting lasting moisture.
Help support the moisture barrier, hydration and skin comfort.
A marine and botanical combination that helps support the skin against daily environmental stressors.
Vitamin E, tetrahexyldecyl ascorbate, CoQ10 and an EGCG derivative provide antioxidant support against environmental stressors.
We follow or exceed clean product standards in each formula that we create. Our standards and why we follow them can be reviewed on our clean products page. Fragrance Free.
The bottle and box are fully recyclable, please recycle.
Not tested on animals.
Water (Aqua), Aloe Barbadensis Leaf Juice, Butyrospermum Parkii (Shea) Butter, C13-15 Alkane, Propanediol, Caprylic/Capric Triglyceride, Sinorhizobium Meliloti Ferment Filtrate, Niacinamide, Octyldodecanol, Cetyl Alcohol, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Simmondsia Chinensis (Jojoba) Seed Oil, Stearyl Alcohol, Squalane, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Ribes Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract, Tetrahexyldecyl Ascorbate, Ophiopogon Japonicus Root Extract, Kappaphycus Alvarezii Extract, Caesalpinia Spinosa Fruit Extract, Tocopheryl Acetate, Panthenol, Ubiquinone, Epigallocatechin Gallatyl Glucoside, Albumin, L-Alanyl-L-Glutamine, Palmitic Acid, Sodium Stearoyl Glutamate, Methyl Glucose Sesquistearate, Polyacrylate Crosspolymer-6, Cetyl Hydroxyethylcellulose, Lecithin, Phytic Acid, Glycerin, Sodium Phytate, Leuconostoc/Radish Root Ferment Filtrate, Caprylhydroxamic Acid, 1,2-Hexanediol, Sorbic Acid, Sodium Chloride. 1-126-1A
The quality of the 7X Calming Complex is guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources.
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This 7X Calming Complex product qualifies for the Money-Back Guarantee.
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Advanced hydration, barrier support, and Defensin-powered age repair for skin that wants more moisture and comfort.
New An extra level of hydration.