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EYE AND LIP RENEWAL DUO
Lip Enhancer & Eye Cream
Ultimate care for delicate areas, visibly smooth and firm the skin around your eyes & lips
[ $170 value ]

2026 Mother's Day Promotion

30 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

EYE AND LIP RENEWAL DUO

Lip Enhancer & Eye Cream
Ultimate care for delicate areas, visibly smooth and firm the skin around your eyes & lips
[ $170 value ]

2026 Mother's Day Promotion

30 % SAVINGS compared to purchasing individually

Limited-time offer. While supplies last.

$170.00
Claim Exclusive Rewards
SKU
10995-m
  1. Value Bundle
  1. Fragrance Free
People en Español Star ProductNewBeautyBeautytap Award: Editor's PickSkincare Anarchy AwardEye Cream Award | NewBeauty Eye Cream Award

Brighten eyes and plump lips with DefenAge’s Eye & Lip Renewal Duo. Combining the powerful 3D Eye Radiance Cream and the breakthrough 12-Factor Revitalizing Lip Enhancer, this set smooths, firms, and revitalizes the look of these delicate areas, giving you a refreshed, youthful look.

Key Benefits:

  • • Eye Radiance: Helps to lift and firm the upper eyelids, reduces the appearance of dark circles, puffiness, and fine lines.
  • • Luscious Lips: Boosts collagen for fuller, firmer lips while deeply hydrating.
  • • Defensin-Loaded: Uses Defensins to regenerate skin look and help to improve texture without irritation.
  • • Gentle & Effective: Safe for sensitive skin, contact lens wearers, and all skin types.

Routine Contents:

  • • 12-Factor Revitalizing Lip Enhancer (Full Size, 0.25 fl. oz.)
  • • 3D Eye Radiance Cream (Full Size, 0.5 fl. oz.)

All products in this collection are supplied in original individual packaging.

Made in the U.S.A.

How To Use

DIRECTIONS

 

How to Use The 12-Factor Revitalizing Lip Enhancer

12-Factor Revitalizing Lip Enhancer Directions

1.

With the cap on, shake the bottle well before first use.

Take off the cap.

Step 1

2.

Apply once or twice daily. Hold the bottle at the indented areas with 2 fingers. Push down on both sides of the applicator to release a drop of the serum.

Step 2

3.

Use the tip of the applicator to smooth one pump over the lips.

Step 3

 

 

How to Use 3D Eye Radiance Cream

3D Eye Radiance Cream

3D Eye Radiance Cream

Daily: AM | PM

After cleansing, while the skin is still moist from rinsing, pump a drop of radiant under-eye treatment onto the applicator. Lightly dab three dots of dark circle eye cream above and below each eye. Using the applicator, massage cream around the eyes.
Suitable for all skin types.

 

 

WARNINGS

These products are for external use only. Keep out of your eyes. If the eye cream enters the eyes, rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

 

 

Clinical Studies

Study on Defensins and Skin Rejuvenation: What It Means for You

Background:

Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.

What are Defensins?

Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.

The Study:

  1. This was a double-blind, vehicle-controlled study, meaning neither the participants nor the researchers knew who was using the Defensin-containing product and who was using a placebo (vehicle).
  2. Participants included men and women with signs of skin aging, such as fine lines, wrinkles, uneven skin tone, and rough texture.
  3. They applied either the Defensin-containing product or a placebo product to their face for 6 weeks.

Key Results:

  1. Visible Improvement: Participants who used the Defensin-containing product showed significant improvement in skin quality compared to those who used the placebo. They experienced smoother skin, fewer wrinkles, improved texture, and a more even skin tone.
  2. Safety: The product was well-tolerated by participants, with no major side effects, making it a safe option for most people.

What This Means for You:

This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.

CLINICAL STUDY ►

Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

All formulas in this collection are fragrance-free.

CLEAN BEAUTY

We have carefully formulated our hand cream products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.

GREEN PLANET

The tubes and boxes are fully recyclable; please recycle.

Our products are not tested on animals.

Guarantees

QUALITY GUARANTEE

Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 

 

MONEY BACK GUARANTEE

This product is qualified for the Money Back Guarantee.

In case of a refund, all products in this bundle should be returned.
Return Policy ►

 

FAQ's
No Questions

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.9136124 / 5 from 764 reviews.

AI Generated Review Summary

Summary topics

Review topics: [results, feels, looks, works, hydration, eyes, value, lines, improvement, lips, cream, duo, lip renewal, serum, applicator, defenage, moisturizer, set, difference, use, bundle].

Review highlights

Reviews

A Luxurious Treat for the Lips!

"I put off purchasing the 12-Factor Revitalizing Lip Enhancer because of the price, but couldn't resist it when DefenAge had a duo package of the Lip Enhancer and 3D Eye Radiance cream at a reduced price. I absolutely love the 12-Factor Revitalizing Lip Enhancer and just ordered more during their latest sale. My lips are softer, plumper, and have more definition and color. I look forward to using it because it makes my lips feel soft, smooth, and hydrated when I apply it. The feeling lasts all day. I then apply it again at night so it can continue to work while I sleep. I saw optimal results after using it for a few weeks, so the results are cumulative over time. As a bonus, the bottle has a gold tip that provides a cooling, luxurious feeling when applying it!"

— Kim B. (5/5)

Amazing Results!

"I'm in my late sixties and didn't have much hope that I would see a noticeable difference around my eyes and lips when I ordered the Eye and Lip Renewal Duo package. However, any amount of improvement would be better than what I was seeing in the mirror daily. Both products have exceeded my expectations, especially after using them consistently for a few weeks. The dark circles under my eyes are almost gone and my under-eye area has filled in. It is no longer hollow looking. Under eye wrinkles have almost completely disappeared and my crows feet are greatly diminished. My eyes look brighter and I can honestly say they look at least ten years younger. My lips are now softer, plumper, more defined, and have more color. My eyes and lips have continued to improve with continued use of the products. I highly recommend."

— Kim B. (5/5)

I can only say when

"I can only say when I look at myself in the mirror, my eye area looks better, smoother appearing, no bags or puffiness, even with persistent crows feet, I'm older so I expect to see signs of aging from years of smiling : )."

— Jean S. (5/5)

I LOVE the Lip Renewal

"I absolutely LOVE the Lip Renewal. I have purchased it several times and will continue to purchase it. It makes my 75 year old lips look young again!"

— Chris T. (5/5)

EYE AND LIP RENEWAL DUO.

"EYE AND LIP RENEWAL DUO are excellent products that work and do not cost an exorbitant amount of money. The company doesn’t promise miracles but offers these and other products that consistently give you better skin that looks glowingly healthy, and refreshed."

— Jill C. (4/5)

Cream really works in reducing

"Cream really works in reducing my dark eye circles by a bit after a few days of usage. Looking forward to results after a monthof usage. Recommended."

— Yvonne M. (5/5)

I love this stuff!

"I love this stuff! I am 75 years old, and my lips never looked better."

— Chris T. (5/5)

Eyes and lips

"I have used Defenage eye cream for several years. When I try other brands I come back to Defenage eye cream. It does soften lines and eliminate other lines around the eye area. The cream does not irritate my eyes. The lip cream is new to me. It does plump my lips and offers short term hydration to my lips. I live in low humidity so hydration is hard to sustain during a 24 hour period."

— Lisa P. (5/5)

I have definitely noticed a

"I have definitely noticed a sustained improvement in shadows under my eyes, eyelid texture and brightness of my eyes."

— Sherri H. (5/5)

This duo is excellent as

"This duo is excellent as they moisturize quite well and repair surface wrinkles and creases with regular use. I highly recommend!"

— Stacey E. (5/5)

Q&A