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8-IN-1 BIOSERUM

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

This product is covered by U.S. Patent No. 11,491,096.

8-IN-1 BIOSERUM

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

This product is covered by U.S. Patent No. 11,491,096.

$198.00
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SKU
10506-m
Hall of Fame AwardSkincare Anarchy AwardNEXT AwardELITE Lifestyle AwardInnovator Award

The Multifaceted Anti-Aging Serum

Embrace the extraordinary capabilities of the 8-in-1 BioSerum, our multifunctional marvel in anti-aging skincare. Intuitively meeting your skin’s unique needs, DefenAge's iconic bestseller is designed to deliver visible, targeted rejuvenation. As a biologically advanced serum concentrate, it features an unprecedented concentration of defensin molecules from the Age-Repair Defensin® Complex, affirming its position as a superior anti-aging serum. Esteemed by dermatologists as an excellent retinol alternative, the 8-in-1 BioSerum serves as a premier rejuvenation serum, either alone or in combination with retinol or bakuchiol serums. Experience the cumulative benefits of eight distinct serums and unveil your best skin ever with this rejuvenating serum.

The Standalone Skincare Wonder

Ideal as a solo skincare powerhouse, the 8-in-1 BioSerum is renowned as a "treatment multiplier" and likened to "microneedling in a bottle." Dermatologists recommend this rejuvenation serum for enhancing the results of aesthetic procedures such as microneedling, RF-microneedling, fractional and ablative laser treatments, and Sofwave. Explore how this anti-aging serum can amplify your treatment outcomes in the Clinical Studies tab.

Read expert opinions here.

Eight Serums in One: Embark on a Journey of Eightfold Rejuvenation

Dive deeper into the unique fusion offered by the 8-in-1 BioSerum. This innovative formula masterfully brings together the benefits of eight specialized serums, delivering a holistic approach to skincare that’s comprehensive and unparalleled:

  • 1. Anti-Oxidants Serum: A robust blend of antioxidants, including Ergothioneine, combats environmental damage while brightening and energizing the skin.
  • 2. Niacinamide Serum: Rich in high-performance Niacinamide (Vitamin B3), it soothes, hydrates, revitalizes the skin’s moisture barrier, and promotes a uniform skin tone.
  • 3. Hyaluronic Acid (HA) Serum: Infused with low-weight Hyaluronic Acid for deep hydration, supplemented by a suite of intense moisturizers.
  • 4. Collagen Serum: Enhanced with beta-defensin 3, the BioSerum boosts collagen, improves elasticity and firmness, and diminishes sagging.
  • 5. Calming Serum: Infused with a fine blend of soothing and calming botanical molecules.
  • 6. Peptide Serum: A bespoke blend of peptides, including Palmitoyl Tripeptide-38, targets critical aging areas, smoothing wrinkles and refining skin texture.
  • 7. DNA-Repair Enzyme Serum: Features enzymes from Mediterranean Arabidopsis, renowned for repairing common DNA damage.
  • 8. Retinol-Alternative Serum: The crowning jewel of the 8-in-1 BioSerum is the highest concentration achievable of Alpha-Defensin 5—DefenAge’s exclusive and revolutionary ingredient. This bio-synthesized molecule marks a triumph in regenerative biology, renowned for its unparalleled ability to activate age-repair pathways, foster new skin development, and serve as a safe, highly effective alternative to retinol. The inclusion of Alpha-Defensin 5 represents not merely an advancement in skincare, but a paradigm shift in our approach to skin rejuvenation and anti-aging. The presence of this potent ingredient in the serum parallels the benefits of traditional retinol serums with a gentler approach, minimizing potential irritation and making it suitable for all skin types.

The 8-in-1 BioSerum transcends traditional skincare, unifying eight essential benefits for a youthful, radiant complexion. It's not just an anti-aging serum; it’s a complete solution for visible skin rejuvenation.

How Our BioSerum Works: The Essence of Anti-Aging and Rejuvenation

Experience the transformative effects of DefenAge's 8-in-1 BioSerum, an exceptional anti-aging and rejuvenation serum. This unique formula improves the overall health and appearance of your skin by:

  • •  Rejuvenating Smoothness: Enhancing visible skin health and quality.
  • •  Reducing Signs of Aging: Minimizing the look of fine lines, wrinkles, pores, and pigmentation.
  • •  Promoting Radiance: Reviving skin’s natural moisture for a luminous glow.
  • •  Brightening Skin Tone: Improving overall clarity and luminosity.
  • •  Renewing the Feeling of Firmness and Elasticity: Restoring texture for a youthful feel.
  • •  Calming Redness: Beneficial for sensitive skin, Helps improve the appearance of skin redness.
  • •  Promoting Skin Barrier and Immunity: Helps to Strengthen skin’s natural defenses for optimal health.

Why Choose Our 8-in-1 BioSerum: A Cut Above the Rest

Our rejuvenation serum stands out as a superior alternative to retinol and bakuchiol serums. The 8-in-1 BioSerum combines advanced, targeted treatment with validated science, creating an unparalleled skincare product:

  • •  Rich in Defensins: Contains five times more defensin molecules than other skincare formulas.
  • •  Feather-Light Feel: Offers a lightweight application for a comfortable wear.
  • •  Versatile Use: Safe and effective for the entire face, skin around eyes, lips, neck, and décolleté.
  • •  Targets Crepey Skin: Excelling on thin skin areas like the neck and arms.
  • •  Rapid Anti-Aging Effects: Delivers visible results within a few weeks.
  • •  Suitable for All: Ideal for daily use, for both men and women, and for all adult ages, including people above 70.
  • •  Gentle for Sensitive Skin: Non-irritating, retinol.
  • •  Broad Tolerance: Effective for diverse skin types, including those with rosacea and melasma.
  • •  Highly effective for pre- and post- aesthetic procedures: Enhances outcomes of aesthetic treatments like microneedling, fractional and ablative laser therapy. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
  • •  Pre-Filler Prime: Ideal for preparing skin before fillers — start using four to six weeks before procedures.
  • •  Customer Favorite: Known as DefenAge's most liked product with impressive feedback.

Made in the U.S.A.

Add These Moisturizers to Your BioSerum Routine:

Ten Specific Ways Leading Dermatologists Recommend Using the 8-in-1 BioSerum:

  1. For daily use. It’s lightweight. “You can’t even feel it when you’re wearing it.” Dermatologist Vivian Bucay, MD
  1. For sensitive skin. It delivers anti-aging results but it’s “not irritating like a retinol or acids.” Dermatologist Anne Chapas, MD
  1. For older age. Even old skin has young dormant cells that can be turned on by defensins. “We saw a marked difference at 2 months” in a 73-year-old patient. Dermatologist Angela Bowers, MD
  1. For better skin quality, including firmer skin, fewer fine lines, more luminosity and clarity, and a reduced appearance of pores. Dermatologist Anne Chapas, MD
  1. After microneedling, patients are “less likely to break out with acne post treatment.” Dermatologist Vivian Bucay, MD
  1. “4 to 6 weeks before having filler procedures” to prep the skin and enhance results. Dermatologist Kathleen Welsh, MD
  1. Before and after ablative skin treatments, which “primes skin to respond more quickly and robustly, healing faster.” Dermatologist Steven Swengel, MD
  1. To target specific areas, including around the eyes and lips. Dermatologist Angela Bowers, MD
  1. Beyond the face: on the neck and décolleté. Dermatologist Steven Swengel, MD
  1. For crepey thin skin on the neck and arms. Dermatologist Kathleen Welsh, MD

REFERENCE:
Dermatologists weigh in on DefenAge’s 8-in-1 BioSerum: Patient outcomes, optimal use. The Dermatology Digest (2021) January, p. 40-42.

FAQ: What makes this serum effective for anti-aging and rejuvenation?

The effectiveness of our 8-in-1 BioSerum in anti-aging and rejuvenation stems from its unique blend of potent ingredients and advanced technology. Central to its formula is the Age-Repair Defensin® Complex, which contains defensin molecules. These bio-synthesized molecules are key to the serum’s effectiveness as they tap into skin's natural regenerative processes. Here's how the serum works to combat aging and visibly rejuvenate your skin:

  • •  Comprehensive Formulation: Unlike traditional serums, our 8-in-1 BioSerum combines the benefits of eight specialized serums in one. Each 'serum' within targets specific aging concerns, from hydration to collagen boosting, offering a complete anti-aging solution.
  • •  Advanced Defensin Technology: The serum's high concentration of Alpha-Defensin 5 and Beta-Defensin 3, exclusive to DefenAge, actively help to rejuvenate skin by promoting new, younger-looking skin and enhancing skin's natural barrier. These molecules are recognized as a safe and effective alternative to retinol, making the serum suitable for even sensitive skin types.
  • •  Multi-Dimensional Benefits: The 8-in-1 BioSerum addresses various visible signs of aging – it smoothens fine lines and wrinkles, improves skin texture, boosts hydration, enhances firmness, and provides potent antioxidant protection. This comprehensive approach ensures visible rejuvenation of the skin.
  • •  Proven Results: Supported by dermatologists and aesthetic professionals, our serum is not just a product but a scientifically-backed solution. Its efficacy in anti-aging and visible skin rejuvenation has been proven through rigorous clinical studies and real-world use.

By integrating these advanced components and science-backed ingredients, the 8-in-1 BioSerum stands out as a highly effective product for both anti-aging and visible skin rejuvenation, delivering noticeable results that are both rapid and long-lasting.

FAQ: How and Why You Should Add the 8-in-1 BioSerum to Your Skincare Regimen?

Dermatologists agree, if you do one nice thing for your skin this year - introduce it to defensin-molecules. Defensins can be incorporated into your existing skincare regimen and do not conflict or compete with other skincare. Whether it’s CHANEL or Clinique, incorporating DefenAge + Defensins can actually enhance the skincare you already know and love.

Consumer survey says that 93% of consumers who use CHANEL

skincare also like the results they see with DefenAge!

/ Survey 2022, data on file /

“Why do CHANEL users like DefenAge? – this is simple – DefenAge’s defensins multiply the effect of other skincare. …Ironically, DefenAge skin care has no competition on the skincare market because it enhances any other skin care brands. Much like laser treatments and microneedling, the topical application of defensins causes our body to message ‘preserved,’ healthy cells to create visibly new skin. I recommend the BioSerum to my patients to activate their “skin’s memory”, triggering skin to look younger, twice a day – in the morning and evening by applying just one drop of DefenAge BioSerum over the moisturizer of their choice,”

-Board-certified dermatologist Natalie M. Curcio, M.D., M.P.H.

Check with us, what other skincare than CHANEL can be combined with DefenAge's defensins for more glowing skin.  

Opinions and Stories

DefenAge® Secures Four Wins at the 2024 Skincare Anarchy Top Picks Beauty Awards

DefenAge®, a leader in science-backed skincare solutions, proudly announces its wins in four categories in Skincare Anarchy’s 2024 Top Picks Beauty Awards. These awards celebrate the best in beauty products and recognize those that stand out for their scientific efficacy, excellence, and innovation. Read more...

Facial Serums - Skincare Superheroes

Serums are workhorses. When formulated with quality, proven ingredients, serums tackle the spectrum of skin aging concerns. This includes diminishing wrinkles, age spots, sun damage, loose and crepey skin, uneven skin tone and more. Read more...

Healthy, Simple, and Safe Skincare Routines with Defensins from Supermodel Veronica Webb

by Veronica Webb, supermodel mom and influencer

Aging powerfully is as much about your attitude as it is about the skincare products you use. Veronica Webb, supermodel, mom, influencer, and beauty writer talks dermatologist recommended anti-aging clean beauty serums, moisturizers, and cleansers. Veronica shares her take simple safe and healthy confidence-boosting skincare routines that make a daily difference. Read more ...

How Effective Is Combining Products From Different Skincare Lines?

by Eliza Cabana, aesthetic and skin rejuvenation guru

Don’t want to give up your Chanel (or other) skincare product for something new? With DefenAge, you don’t have to! One expert explains how you can combine your favorite products with the DefenAge line to get all the benefits of both. Read more ...

The Secret to Effective 'Anti-Aging'

by Eliza Cabana, aesthetic and skin rejuvenation guru

Who doesn’t love a good anti-aging cream? But will it actually turn back the clock for your skin? One expert shares her perspective on the “anti-aging” misnomer as well as tips for what steps you can take to get the most out of your skincare routine. Read more...

Introduce Your Skin to the Benefits of DefenAge’s 8-in-1 BioSerum This Year

DefenAge’s 8-in-1 BioSerum may be lightweight, but it packs more Defensin molecules than any of DefenAge’s other products. Age-Repair Defensins wake up dormant cells to make brand-new, healthy cells. The result is skin that looks brighter, smoother, and firmer. If you don’t want to use retinol, try the dermatologist recommended skin care from DefenAge, including 8-in-1 BioSerum. Age-Repair Defensins are just as effective as retinol. Read more...

How to Get the Best Results From Your Anti-Aging Skin Care Products

The best anti aging skin care products will help your skin look brighter, smoother, plumper, and reduce the appearance of wrinkles. But if you want to truly maximize the product’s effectiveness, there are several things to keep in mind. Using skin care products that address signs of aging is a commitment, but it’s worth it when you start seeing results. Read more...

DefenAge’s Anti-Aging Serum: A Spring Skin Care Must-Have

The 8-in-1 BioSerum, anti-aging serum, from DefenAge is a best-selling product with the highest concentration of Age-Repair Defensins. Defensins are molecules that prompt dormant cells to make brand-new, healthy skin cells. DefenAge is the only brand to use Age-Repair Defensins, a proprietary ingredient. The result is new skin cells that look younger and healthier. DefenAge’s products don’t merely cover signs of visible aging.

How To Use

DIRECTIONS

 

8-in-1 BioSerum

8-in-1 BioSerum 

Daily: AM | PM

Place one pump of the 8-in-1 BioSerum Concept Anti-Aging Cream onto fingertips. Lightly massage, first around the eyes, then over the entire face. Use a second pump on the neck and décolleté. Always follow the one pump rule - one pump per area if you would like to use this product on the arms, elbows, and knees. Layer sunscreen on top of the bio serum in the morning or day time before leaving house. 

This product is suitable for all skin types.

 

 

 

WARNINGS

For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

 

Clinical Studies

The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 11 clinical studies.

MULTI-CENTER STUDY DETAILS:

The 8-in-1 BioSerum was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.

Additional ophthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.

The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.

All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.

We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile. Because of the exceptional results seen with the use of the 8-in-1 BioSerum and the unique mechanism of action of Defensin-molecules, the 8-in-1 BioSerum is commonly called "microneedling in a bottle."

Before and After

Before and After

MULTIPLY RESULTS OF YOUR AESTHETIC TREATMENT:

Microneedling and RF-Microneedling: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Fractional laser: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Ablative laser: 7 days post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Safewave and other non-invasive procedures: Immediately post-procedure, apply Clinical Power Trio for 2-4 weeks.

Before and After

Before and After

Ingredients

8-in-1 BioSerum Ingredients

Key Performance Ingredients and Technologies

 

Age-Repair Defensins® | 5X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.

Niacinamide

hydration • firmness & elasticity • brightening

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone. The 8-in-1 BioSerum is named 'Best Niacinamide and Hyaluronic Acid Serum of 2024' by Good Housekeeping magazine.

Hyaluronic Acid | Low Molecular Weight

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Fine Blend of Soothing and Calming Ingredients

• addresses inflamm-aging • skin calming & soothing •

This formula is infused with a powerful and concentrated composition of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.

CLEAN SKINCARE

The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excused from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.

GREEN PLANET

The bottle, box and package components are fully recyclable, please recycle.

We do not test products on animals.

INGREDIENT LIST

8-in-1 BioSerum | Concept Anti Aging Cream

Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Octyldodecanol, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Rides Nigrum (Black Currant) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Ergothioneine, Rosmarinus Officinalis (Rosemary) Leaf Extract, Helianthus Annuus (Sunflower) Seed Oil, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Tocopherol, Epigallocatechin Gallatyl Glucoside, Albumin, l-Alanyl-l-Glutamine, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride.
Fragrance free.

This product does not contain retinol and should not be considered as a retinol serum.

Guarantees

QUALITY GUARANTEE

Quality guaranteed ONLY when 8-in-1 BioSerum is sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 

 

MONEY BACK GUARANTEE

8-in-1 BioSerum | Concept Anti Aging Cream (bio serum) is qualified for the Money Back Guarantee.
Return Policy ►

 

FAQ's
What makes this serum effective for anti-aging and rejuvenation?
The effectiveness of our 8-in-1 BioSerum in anti-aging and rejuvenation stems from its unique blend of potent ingredients and advanced technology. Central to its formula is the Age-Repair Defensin® Complex, which contains defensin molecules. These bio-synthesized molecules are key to the serum’s effectiveness as they tap into skin's natural regenerative processes. Here's how the serum works to combat aging and visibly rejuvenate your skin: Comprehensive Formulation: Unlike traditional serums, our 8-in-1 BioSerum combines the benefits of eight specialized serums in one. Each 'serum' within targets specific aging concerns, from hydration to collagen boosting, offering a complete anti-aging solution. Advanced Defensin Technology: The serum's high concentration of Alpha-Defensin 5 and Beta-Defensin 3, exclusive to DefenAge, actively help to rejuvenate skin by promoting new, younger-looking skin and enhancing skin's natural barrier. These molecules are recognized as a safe and effective alternative to retinol, making the serum suitable for even sensitive skin types. Multi-Dimensional Benefits: The 8-in-1 BioSerum addresses various visible signs of aging – it smoothens fine lines and wrinkles, improves skin texture, boosts hydration, enhances firmness, and provides potent antioxidant protection. This comprehensive approach ensures visible rejuvenation of the skin. Proven Results: Supported by dermatologists and aesthetic professionals, our serum is not just a product but a scientifically-backed solution. Its efficacy in anti-aging and visible skin rejuvenation has been proven through rigorous clinical studies and real-world use. By integrating these advanced components and science-backed ingredients, the 8-in-1 BioSerum stands out as a highly effective product for both anti-aging and visible skin rejuvenation, delivering noticeable results that are both rapid and long-lasting.
Read More
Why should the 8-in-1 BioSerum be layered last in a skincare routine?
The reason is because of a unique property of defensin molecules. Our bio serum contains DefenAge’s highest dose of defensins, which not only stimulate new skin, but also have shown to be effective in preventing water loss via the skin-surface’s natural “tight junction” mechanism. In other words, defensins “lock gaps” between surface cells; therefore water cannot go out, it is locked inside, but together with this – nothing goes in, meaning that if you apply any other creams or serums on top of the 8-in-1 BioSerum, their ingredients may not be absorbed. We recommend that all skin care products in your routine be layered before the 8-in-1 BioSerum, only makeup and sunscreen should be layered on top in the morning, and nothing should be layered at night; please review the dermatologist recommendations on night skincare routines on our How-To Page.
My skin is glowing right after a week of the use of 8-in-1 BioSerum, can I increase the number of pumps for even more results?
Please be patient, more is not better. More results will not show up just because of an overuse of the bio serum. Concentrations of ingredients are very well balanced in the formula, please just follow with the recommended dosage and do it regularly: morning and night – results will not disappoint. Use one pump of the 8-in-1 BioSerum on the face and one on the neck. We also recommend exfoliating the skin regularly to see results faster – removing old cells from skin’s surface will unveil beautiful new skin; DefenAge’s gentle solution for exfoliation is the 2-Minute Reveal Masque.
Do I need to use a Vitamin C serum together with the Defensin anti-aging serum?
DefenAge’s 8-in-1 BioSerum contains a fine blend of naturally powerful anti-oxidants. We do not restrict DefenAge users form the using vitamin C serum, although we believe that it is unnecessary.
Is it true that makeup will be applied easier on skin treated with 8-in-1 BioSerum?
This is true. Due to the high concentration of defensin molecules, the skin will become smoother after using 8-in-1 BioSerum, therefore makeup will be applied easier than usual. Some consumers even say, “I do not need foundation after I started using DefenAge's bioserum.”
Is 8-in-1 BioSerum good for acne prone skin?
Yes it is. The 8-in-1 BioSerum is safe for acne prone skin, our bio serum underwent multiple safety studies that returned an outstanding safety profile. Please be sure that you use the exact quantity of the product that we recommended, and do not exceed it: 1 pump of the bio serum for entire face and 1 pump on the neck.

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.933631 / 5 from 1567 reviews.

AI Generated Review Summary

Summary topics

Review topics: [size, absorbs, results, issues, irritation, improvement, wrinkles, scent, weight, quality, spots, shipping, benefits, feels, texture, works, packaging, formula, skin, use, looks, amount, glow, lines, face, compliments, pores, difference, bottle, appearance].

Review highlights

Reviews

Exceptional Product!

"The DefenAge 8-In-1 Bioserum delivers as promised. The serum goes on smooth and feels light and luxurious. It immediately softens the skin and makes it feel exceptionally smooth. Using the serum evened out my skin tone and reduced pore size. My face has more elasticity and my skin looks firmer. My skin looks and feels healthier than it has in years. That's saying a lot for someone who is in her late sixties! I can see why the 8-In-1 Bioserum is a top-selling product."

— Kim B. (5/5)

Love the ingredients

"I don't know that I am seeing results but I believe in the product and technology of the product. It doesn not mix well with some other products as it or the other products pills on my face so just try it on a small area of your face first. The only thing I don't like is the price. My husband freaks out at the amount of money I spend on skincare. Sales would be nice!"

— Marlene M. (4/5)

Impressed

"I’ve been using about three weeks and so far, so good. Gentle, slow results. My skin looks healthier, smoother, brighter. Less need for tinted anything coverage. Looking forward to seeing how far this takes my skin"

— Torie D. (5/5)

Great!

"Really love it! It fits so well with the cleanser and moisturizer - would definitely buy again! Not sure about full results yet as it's only been about a month, but it feels great!"

— Shannon P. (5/5)

great product

"I love the feel and the gentleness this serum and recommend to a anyone that can’t use retinol"

— Anjela I. (5/5)

Fountain of Youth in a Bottle

"I really believe that this serum has helped my skin from aging. I am a customer for life."

— Janis F. (5/5)

Defenage is the only product

"Defenage is the only product line that I have ever used where I honestly noticed a visible difference in skin quality."

— Angelena B. (5/5)

Do it for YOU!

"I've noticed a definite improvement in the overall appearance and feel of my skin since using the Defenage routine and the 8 in 1 Bioserum is the last item I add to seal it all in. I just wish I had found Defenage years ago!!!"

— Margo O. (5/5)

Great product

"I've been using Defenage products for years and always get compliments on my skin."

— Denise C. (5/5)

Scientifically proven

"A silky decadent scientifically proven serum"

— Nicole S. (5/5)

Q&A

Will this smooth out stubborn lip lines around mouth? And also firm the jowl area?
Our 8-in-1 BioSerum is designed to deliver visible, targeted rejuvenation and includes a blend of ingredients that support skin firmness and smoothness. It contains peptides and collagen-boosting components that can help improve skin elasticity and firmness, which may benefit areas like the jowl. Additionally, it has ingredients that smooth fine lines, which could help with lip lines around the mouth. Our BioSerum is known for its ability to enhance skin texture and firmness, making it suitable for addressing concerns such as crepey skin and fine lines in delicate areas like around the lips and jawline. It is also gentle and suitable for sensitive skin, making it a good option for these areas. If you want to target specific areas, we also recommend using our 6-Week Perfection Neck Cream for the jowl area and our 12-Factor Revitalizing Lip Enhancer to help smooth stubborn lip lines around mouth. The 8-in-1 BioSerum can be used in conjunction with both of these products for a comprehensive routine targeting the mouth and jawline.
Is it ok to apply 8 in 1 on cleansed skin instead of last
The recommended way to use our 8-in-1 BioSerum is to apply it as the last step in your skincare routine after cleansing and applying any other skincare products (except sunscreen and makeup). This is because the defensin molecules in the serum have a unique property of "sealing" the skin barrier, which can reduce the penetration of other products if applied afterward. So, for best results, apply the 8-in-1 BioSerum on cleansed skin after your other treatments and moisturizers, making it the final step before sunscreen or makeup in the morning, and the last step at night.
Can I use serum with copper peptides?
Yes, you can certainly use our 8-in-1 BioSerum with copper peptides! Our 8-in-1 BioSerum can help enhance results from using copper peptides by delivering a powerful combination of age-repair defensins and a blend of peptides (including Palmitoyl Tripeptide-38), antioxidants, and hydrating ingredients that work synergistically with copper peptides to support skin rejuvenation. Regardless of the product, the rule of thumb with our line is to apply all other products (besides sunscreen & makeup) -before- our creams and serum.
What is the exact routine for using the serum. Pls be specific bc the website info doesn’t provide a clear plan. One place says put the serum in LAST. This is confusing since most serums are used FIRST. Also, can the serum be used around the eyes? When do you use the eye serum? Very confusing! Thx.
This is the order for using the products that we recommend: 1. Facial cleanser, morning and evening. Please use any cleanser you like or DefenAge's 1-Step Multi-Cleanse. 2. 2-Minute Reveal Masque, once or twice a week. 3. Any other skincare products that you would like to use (besides sunscreen). 4. 24/7 Barrier Balance Cream on the face, except the skin around eyes; morning and evening. 5. 3D Eye Radiance Cream for the skin around eyes; morning and evening. 6. 6-Week Perfection Neck Cream for the skin of the neck; morning and evening. 7. 8-in-1 BioSerum on the entire face INCLUDING THE SKIN AROUND THE EYES (our BioSerum has been ophthalmologist tested and is safe for use around the entire eye area); morning and evening. The overall rule is simple, DefenAge's creams and serum should be the last steps in your skincare routine; only sunscreen and makeup should be layered on top of our creams and serum in the morning and nothing layered on top at night. It is a little different than the skin care industry norm, but the reason why we suggest to apply our BioSerum last is because the defensin molecules that are in our products have an extra beneficial activity to "close gaps" between keratinocytes in the stratum corneum. Scientifically, it's called "stimulate tight junctions." It means that defensins sort of "seal" gaps between keratinocytes to prevent water loss from the skin. The 8-in-1 BioSerum contains the highest concentration of defensins, meaning that once the BioSerum is applied, penetration into skin of other products will be compromised and not as effective (if "nothing goes out" - then "nothing goes in"). Because of this unique property, we always advise applying the BioSerum as the last step in your skincare regimen (besides sunscreen and makeup).
can i apply this serum after a micro-needle treatment?
Yes! Our 8-in-1 BioSerum is well known as a "treatment multiplier." Dermatologists recommend the 8-in-1 BioSerum for both pre- and post- aesthetic procedures to amplify the results of microneedling, RF-microneedling, fractional and ablative laser, and Sofwave. Here are the instructions for how to use the 8-in-1 BioSerum post-procedure: Microneedling and RF-Microneedling: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks. Fractional laser: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks. Ablative laser: 7 days post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks. Safewave and other non-invasive procedures: Immediately post-procedure, apply Clinical Power Trio for 2-4 weeks.