10 YEAR COLLECTION
[ $1,154 value ]
Limited Time
Enjoy 48% SAVINGS compared to purchasing individually
+ GIFT: NEW 7X Calming Complex
+ FREE 100% Silk Pillowcase
TAKE AN ADDITIONAL
15 % OFF select Holiday Collections
With this offer, the collection is $508.30. Discount applied automatically in the cart.



















2025 Science of Skin Award, Most Innovative Skincare Range, Top Medical Skincare Lines, Most Innovative 2024 Fast Company, Star Products Award, Eye Product of the Year, Best Neck Cream, Best-In-Class Body, Best Brightening Mask, Non-Surgical Innovator of the Year, Beauty Choice Award, Best Eye Cream For Dark Circles, The Secret to a Firmer Neck Award, Best Nail Serum, Star Products Award, Editor's Pick, Best Age-Defying Lip Serum.
The 10 Year Anniversary Collection: 10 Years. 11 Innovative Products. One Complete Set.
Celebrate a decade of DefenAge with the 10 Year Anniversary Collection— a complete 11-product set featuring our most advanced, award-winning formulas in their largest sizes. Powered by our patented Age-Repair Defensins®, this exclusive collection showcases a decade of skincare innovation. From our hydrating cleanser to our cutting-edge serum, this collection offers targeted formulas for skin, lips, body, and hair. Every product reflects a chapter in our journey to redefine how we age, empowering you to look and feel your best, at every stage of life.
For limited time, this season, your 10 Year Collection also includes two exclusive gifts: our 100% Silk Pillowcase and NEW! 7X Calming Complex!
Available for a limited time and while supplies last.
The 10 Year Anniversary Collection Includes:
The 10 Year Anniversary Collection is presented in its largest sizes for exceptional value and includes:
- • 8-in-1 BioSerum: A multifaceted anti-aging serum promoting new skin via Age-Repair Defensin-molecules to visibly renews the skin's firmness, elasticity, and texture. [Mega-size: 1.5 fl. oz.]
- • 24/7 Barrier Balance Cream: Deep hydration and skin barrier renewal for smooth, radiant skin [Full-size: 1.5 fl. oz.]
- • 3D Eye Radiance Cream: Targets dark circles and puffiness by visibly lifting, firming, and smoothing around the eye area. [Full-size: 0.5 fl. oz.]
- • 6-Week Perfection Neck Tightening Cream: Visibly lifts, firms and brightens the neck and décolleté [Full-size: 1.5 fl. oz.]
- • 12-Factor Revitalizing Lip Enhancer: Enhances fullness, smoothness, and definition for younger-looking lips [Full-size: 0.25 fl. oz.]
- • 10 Luxe Hand & Body Cream: Hydrates, firms, and improves the appearance of crepey skin. [Full-size: 4 fl. oz.]
- • 2-Minute Reveal Masque: Gently removes dead skin cells to reveal fresh younger-looking skin in just minutes [Full-size: 2.5 oz.]
- • 1-Step Multi-Cleanse: Hydrates, cleanses, and prepares skin for Age-Repair Defensin® treatments. [Mega-size: 5 oz.]
- • 360-Rejuvenation Nail Root Serum: Helps to strengthen, smooth and hydrate nails and cuticles [Full-size: 0.22 fl. oz.]
- • 150K Hair Follicle Serum: Helps reduce signs of shedding and hair falling out. for stronger, fuller-looking hair [Full-size: 1 fl. oz.]
- • TWO EXCLUSIVE GIFTS:
- • 100% Silk Pillowcase [First 500 orders]: Luxuriously soft and gentle to help reduce friction and support smoother, healthier-looking skin and hair [King-size: 20 x 36 in.].
- • NEW 7X Calming Complex: A soothing formula designed to protect your skin against hidden inflammation that accelerates aging [Full-size: 0.5 fl. oz.].
All products in this collection are presented in DefenAge’s signature gift box.
Made in the U.S.A.
DIRECTIONS
STEP ONE | 1-Step Multi-Cleanse
Daily: AM | PM
Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with clean towel. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream and 6-Week Perfection Neck Cream).
Suitable for all skin types.
STEP TWO - FACE | 24/7 Barrier Balance Cream
Daily: AM | PM
Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
STEP TWO - EYES | 3D Eye Radiance Cream
Daily: AM | PM
After cleansing, while skin is still moist from rinsing, pump a drop of cream onto applicator. Lightly dab three dots of cream above and below each eye. Using applicator, massage cream around eyes. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
STEP TWO - NECK | 6-Week Perfection Neck Cream
Daily: AM | PM
Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.
STEP THREE | 8-in-1 BioSerum
Daily: AM | PM
Apply after the 24/7 Barrier Balance Cream,
3D Eye Radiance Cream, and 6-Week Perfection Neck Cream.
30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.
STEP THREE - LIPS | 12-Factor Revitalizing Lip Enhancer
Daily: AM | PM
Please visit the 12-Factor Revitalizing Lip Enhancer page for the usage directions for this innovative product ►
1-2 Xs A WEEK | 2-Minute Reveal Masque
Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream and 6-Week Perfection Neck Cream).
Not recommended for acne, extremely sensitive or abraded skin.
HAND & BODY | 10 Luxe Hand & Body Cream
Daily: AM | PM
Apply once or twice daily after showering or bathing. Smooth and lightly massage the cream from ankles to waist, then hands, arms, and shoulders, followed by rest of the body. Apply 8-in-1 BioSerum on elbows, knees, and other challenging areas to maximize results.
Suitable for all skin types.
NAILS | 360-Rejuvenation Nail Root Serum
Daily: AM | PM
Please visit the 360-Rejuvenation Nail Root Serum page for the usage directions for this innovative product ►
HAIR & SCALP | 150K Hair Follicle Serum
Daily: AM | PM
Please visit the 150K Hair Follicle Serum page for the usage directions for this innovative product ►
DefenAge is proven in more than 30 clinical studies. All DefenAge formulas are dermatologist tested. 1-Step Multi-Cleanse, 3D Eye Radiance Cream, and 8-in-1 BioSerum are also ophthalmologist tested.
Multi-center placebo-controlled double-blind clinical study shows that DefenAge “globally improves the visual appearance of aging skin” and “offers most of the advantages of time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin.”
Journal of Drugs in Dermatology 2018, 17(4): p. 426-441Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD
Learn More ►
Please visit the 360-Rejuvenation Nail Root Serum page to review clinical data relating to this innovative product ►
Please visit the 150K Hair Follicle Serum page to review clinical data relating to this innovative product ►
KEY PERFORMANCE INGREDIENTS & TECHNOLOGIES
Age-Repair Defensins® | DefenAge's Exclusive
promotes new skin • anti-aging on a global scale
Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.
Niacinamide
hydration • firmness & elasticity • brightening
Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.
Hyaluronic Acid
Liposome Encapsulated (Cream) | Low Molecular Weight (Serum)
• hydration •
Promotes hydration and improves texture for remarkably smooth and even skin.
Fine Blend of Soothing and Calming Ingredients
• addresses inflamm-aging • skin calming & soothing •
This formula is infused with a powerful and concentrated composition of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.
Ophiopogon Japonicus Root Extract and
Sinorhizobium Meliloti Ferment
skin's barrier balance • natural hydration
The powerful blend of natural extracts balances the skin’s barrier, saves the skin’s natural moisture, and promotes the levels of Natural Moisturization Factors (NMFs).
Squalene
moisturiozation • antioxidant
Energizes skin hydration. Prevents moisture loss while restoring visible skin’s suppleness and flexibility. Fights skin damage and free radicals.
Panthenol
soothing • protection
Helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. Hydrates the skin from within. Proven humectant.
Fine Blends of Natural Antioxidants, Enzymes
and Hydrating Technologies
antioxidants • hydration • soothing
Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.
CLEAN BEAUTY
This bundle contains eight of DefenAge’s top products; all of them are formulated based on the enhanced clean beauty standards. Find more information about our standards and why we raised the bar for skincare safety requirements on our Clean Beauty page.
GREEN PLANET
The bottles, tubes, and boxes are fully recyclable, please recycle.
Not tested on animals.
INGREDIENT LISTS
The detailed ingredient lists can be reviewed on the individual product pages:
24/7 Barrier Balance Cream ►
8-in-1 BioSerum ►
12-Factor Revitalizing Lip Enhancer ►
WARNINGS
For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.
QUALITY GUARANTEE
Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources.
MONEY BACK GUARANTEE
This product is qualified for the Money Back Guarantee.
In case of a refund, all products in this bundle should be returned.
Return Policy ►
FREQUENTLY BOUGHT TOGETHER





[ $1,154 value ]
Limited Time
Enjoy 48% SAVINGS compared to purchasing individually
+ GIFT: NEW 7X Calming Complex
+ FREE 100% Silk Pillowcase
TAKE AN ADDITIONAL
15 % OFF select Holiday Collections
With this offer, the collection is $508.30. Discount applied automatically in the cart.