High-Performing Cosmetic Treatment for the Hands, Elbows, Knees, and Ankles.


High-Performing Cosmetic Treatment for the Hands, Elbows, Knees, and Ankles.
$424.00 Regular Price $522.00
/ $318 with free account /
In stock

The Ultimate Hand Trio is a unique and exclusive way to refresh the skin on your hands and elbows using topical application alone. The core treatment uses DefenAge's Hero Blend of age-repairing Defensins, which promote young and healthy cells, producing fresh new skin. Maintaining a daily skincare routine for your hands is just as important as caring for the skin on your face. Since we do not apply makeup to our hands to offer protection, they can start to show signs of premature aging. The Ultimate Hand Trio repairs, hydrates, and renews in 3 easy steps:

  • 2-Minute Reveal Masque gently removes dead skin cells to reveal fresh new skin and a brighter tone. Named The Best Brightening Mask by NewBeauty Magazine. Supplied in full size, 2.5 oz.
  • 10 Luxe Hand & Body Cream protects and restores lost moisture via multi-action activities and an advanced four-pillar revolutionary formulation. Supplied in full size, 4 fl. oz.
  • 8-in-1 BioSerum promotes new skin via 5-time concentrated defensins and visibly renews the skin's firmness, elasticity, and texture. Supplied in mega size, 1.5 fl. oz.


Try this luxurious, three-step professional ritual for yourself, and you could experience firmness in the skin's elasticity, brighter tone and more hydrated skin in as little as 7-10 days.

  • •  Provides anti-aging benefits on a global scale. Reverses signs of premature skin aging and sun damage.
  • •  Promotes new, ‘younger’ skin.
  • •  Effective on both the hands and elbows, visibly revives their smooth texture and revitalizes softness.
  • •  Visibly enhances firmness and cosmetic elasticity.
  • •  Refines the surface skin texture.
  • •  Provides both instant and long-lasting hydration, including in dry or winter climates.
  • •  Boosts natural moisture retention leaving skin feeling firmer and plumper immediately.
  • •  Relieves dryness and itching.
  • •  Balances the skin’s barrier function.
  • •  Promotes the skin’s natural Hyaluronic Acid, Laminin, and Elastin.
  • •  Improves visible skin thickness.
  • •  Skin tone appears luminous and healthy.
  • •  Acts fast: first results from ‘immediate’ to 1 week, full range of results in 6 weeks.
  • •  Can be used together with a Retinol, if Retinol is tolerated. Effective as a Retinol alternative for Retinol-sensitive skin to deliver Retinol-like results.
  • •  Free from irritants, suitable for all skin types. 
  • •  Meets clean beauty standards. Fragrance free.


All products in the collection are supplied in their largest available sizes and in their original individual packaging.


All products are made in the U.S.A.


Be the first to try this high-performing cosmetic treatment first-hand! We back up the performance with clinical studies and our reputation!



1-Step Multi-Cleanse

WEEKLY - Exfoliation

2-Minute Reveal Masque

1-2 Xs A Week

Once or twice a week after washing your hands, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to both hands and the same amount of masque on both elbows. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse treated areas thoroughly. We recommend applying the masque on the elbows before shower for easy wash-off.
Not recommended for extremely sensitive or abraded skin.



3D Eye Radiance Cream

STEP TWO - Moisturizing

10 Luxe Hand & Body Cream

Daily: AM | PM

Apply once or twice daily after washing your hands or after showering. Distribute and massage one pump of the cream on both hands, use another pump to treat both elbows. Wait 30 seconds, then apply 8-in-1 BioSerum | STEP THREE.
Suitable for all skin types.



8-in-1 BioSerum


8-in-1 BioSerum

Daily: AM | PM

Apply after 10 Luxe Hand & Body Cream.

30 seconds after applying 10 Luxe Hand & Body Cream, distribute and massage 1 pump of serum between both hands and use another pump on both elbows. While the skin is still moist, lightly massage it into the skin. Follow with sunscreen.
Suitable for all skin types.




For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The multi-parameter clinical study is in a clinical dermatology magazine, and the results are very exciting! Join DefenAge® Skin Club to receive an update as soon as the data becomes publicly available. It is free and does not require a subscription or purchase commitment.


Be the first to try this high-performing cosmetic treatment first-hand!

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:


All formulas in this bundle are fragrance-free.



We have carefully formulated our products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.


The bottles, tube, and boxes are fully recyclable, please recycle.

Not tested on animals.


Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 



This product is qualified for the Money Back Guarantee.

In case of a refund, all products in this bundle should be returned.
Return Policy ►


What causes extreme dryness in hands?
Dry hands are most commonly caused by changes in temperature such as going from extreme cold weather, to constant handwashing which can strip your skin from natural oils that protect the skin's barrier to certain medical conditions that can result in severely chapped and rough hands. Genetics can also play a role in the condition of our hands along with underlying health concerns or years of neglect to the delicate skin, especially on the back of our hands.
What can I do for severely dry hands?
Applying sunscreen daily to combat the signs of premature aging on the delicate skin on the backs of hands. Using an exfoliator like the 2-Minute Reveal Masque, can help remove dull, dry skin while revealing fresher, younger-looking skin in minutes. After prepping with the 2-Minute Reveal Masque, hydrating with the 10 Luxe Hand & Body Cream that includes our hero blend of ingredients, including our proprietary anti-aging formula of Defensin-Molecules, to provide a comprehensive barrier balancing along with soothing and calming Sea Whip and Panthenol. Rounding out our Trio, is the 8-in-1 BioSerum which delivers 5X the amount of Defensins, to visibly improve skin's firmness, elasticity and texture to complete your hand treatment regimen. Renewing with the 8-in-1 BioSerum which delivers 5X the amount of Defensins, to visibly improve skin's firmness, elasticity and texture to complete your hand treatment regimen.