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High-Performing Cosmetic Treatment for the Hands, Elbows, Knees, and Ankles.


High-Performing Cosmetic Treatment for the Hands, Elbows, Knees, and Ankles.
$424.00 Regular Price $522.00
/ $318 with free account /
In stock

DefenAge Hand Cream Details

The Ultimate Hand Trio is a unique and exclusive hand repair cream that helps refresh the skin on your hands and elbows via topical application. The core hand moisturizer treatment uses DefenAge's Hero Blend of age-repairing Defensins, which trigger young and healthy cells to produce fresh new skin.

Maintaining a daily skincare routine for your hands is just as important as caring for the skin on your face. Since we do not apply makeup to our hands to offer protection, they can start to show signs of premature aging sooner. The Ultimate Hand Trio lotion for dry hands repairs, hydrates, and renews in 3 easy steps:

  • 2-Minute Reveal Masque Gently removes dead skin cells to reveal fresh new skin and a brighter tone. It was named The Best Brightening Mask by NewBeauty Magazine. This hydrating mask is supplied in full size, 2.5 oz.
  • 10 Luxe Hand & Body Cream Protects and restores lost moisture via multi-action activities and an advanced four-pillar revolutionary formulation. This moisturizing hand cream is supplied in full size, 4 fl. oz.
  • 8-in-1 BioSerum Promotes new skin via 5-time concentrated Defensins and visibly renews the skin's firmness, elasticity, and texture. This enhanced serum is supplied in mega-size, 1.5 fl. oz.

Try this luxurious, three-step professional hand moisturizer routine for yourself. You could experience firmness in the skin's elasticity, brighter tone, and more hydrated skin in as little as 7-10 days.

Here are additional benefits of our hand cream for dry hands.

  • •  Provides anti-aging benefits on a global scale while reversing signs of premature skin aging and sun damage.
  • •  Promotes new, ‘younger’ skin.
  • •  Effective on both the hands and elbows and visibly revives their smooth texture and revitalizes softness.
  • •  Visibly enhances firmness and cosmetic elasticity.
  • •  Refines the surface skin texture.
  • •  Provides both instant and long-lasting hydration, including in dry or winter climates.
  • •  Boosts natural moisture retention, leaving skin feeling firmer and plumper immediately.
  • •  Relieves dryness and itching.
  • •  Balances the skin’s barrier function.
  • •  Promotes the skin’s natural Hyaluronic Acid, Laminin, and Elastin.
  • •  Improves visible skin thickness.
  • •  Skin tone appears luminous and healthy.
  • •  Acts fast: first results from ‘immediate’ to 1 week, full range of results in 6 weeks.
  • •  Can be used together with a Retinol if Retinol is tolerated. Effective as a Retinol alternative for Retinol-sensitive skin to deliver Retinol-like results.
  • •  Free from irritants, suitable for all skin types.
  • •  Meets clean beauty standards and is fragrance-free

All of our moisturizing hand cream products in the collection are supplied in their largest available sizes and in their original individual packaging.

All hydrating hand cream products are made in the U.S.A.

Be the first to try this high-performing cosmetic hand repair cream treatment firsthand! We back up the performance of these hand-moisturizing products with clinical studies and our reputation.

How to Use Our Hand Repair Cream

Hand and Elbow Treatment Ritual

1-Step Multi-Cleanse

WEEKLY - Exfoliation

2-Minute Reveal Masque

1-2 Xs A Week

Once or twice a week after washing your hands, dry your skin thoroughly. Apply a dollop of the hydrating hand cream masque, about the size of a quarter, to both hands and the same amount of masque on both elbows. Using dry fingertips, gently massage the masque in a circular motion for 20 seconds or less, depending on skin sensitivity. Wait 2 minutes. With moistened fingertips, massage until the crystals are completely dissolved. Rinse treated areas thoroughly. We recommend applying the hand moisturizer masque on the elbows before showering for easy wash-off.
Not recommended for extremely sensitive or irritated skin.

3D Eye Radiance Cream

STEP TWO - Moisturizing

10 Luxe Hand & Body Cream

Daily: AM | PM

Apply the moisturizing hand cream once or twice daily after washing your hands or showering. Distribute and massage one pump of the hand cream on both hands, and use another pump to treat both elbows. Wait 30 seconds, then apply 8-in-1 BioSerum | STEP THREE.
Suitable for all skin types.

8-in-1 BioSerum


8-in-1 BioSerum

Daily: AM | PM

Apply after 10 Luxe Hand & Body Cream.

Thirty seconds after applying 10 Luxe Hand & Body Cream, distribute and massage 1 pump of serum between both hands and use another pump on both elbows. While the skin is still moist, lightly massage it into the skin. Follow with sunscreen.
Suitable for all skin types.


These hydrating hand cream products are for external use only. Keep out of the eyes. If the product enters your eyes, rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

Hand Cream Clinical Studies

The multi-parameter clinical study is in a clinical dermatology magazine, and the results are very exciting! Join DefenAge® Skin Club to receive an update as soon as the data becomes publicly available. It is free and does not require a subscription or purchase commitment.

Be the first to try this high-performing cosmetic hand cream treatment first-hand!

Hand Moisturizer Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

All hydrating hand cream formulas in this bundle are fragrance-free.


We have carefully formulated our hand cream products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.


The bottles, tubes, and boxes of these hand cream products are fully recyclable; please recycle.

Our hand moisturizers are not tested on animals.

Hand Repair Cream Guarantees

Quality Guarantee

The quality of our hand cream products is guaranteed ONLY when sold by or authorized professionals; otherwise, it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 


These hand cream products qualify for the Money-Back Guarantee.

In case of a refund, all products in this bundle should be returned.

Return Policy ►
How is a hand cream different from a foot cream?
The differences between a hand cream and a foot cream are their thickness and absorption. The skin on your hands is thinner and more delicate, meaning you need a thinner hand cream formula that can be absorbed quickly. The skin on your feet is thicker and rougher, so you’ll need a foot cream that is thicker and takes a little while to absorb into the skin. Hand cream and foot cream are alike only because people use each of them to make their skin feel softer and smoother.
How does hand cream help dry hands?
When your hands are dry, they may feel tight, itchy, and rough, which is why people reach for hand creams. A hydrating hand cream contains ingredient groups like emollients and occlusives, which help soften and smooth the skin on your hands while also sealing in moisture. The best hand creams for dry skin will tackle the tight and itchy feelings while smoothing out the roughness, leaving you with softer, smoother hands.
What can I use for cracked hands?
Cracked skin is painful and can become more irritated if you use ineffective products to solve the problem. Here are a few products you can use to help heal mildly cracked hands. Hydrating hand cream — A good hand cream will keep your hands hydrated while also sealing in the moisture you already have. Cracking can get worse if your skin dries out more, so you want to do all you can to keep moisturizing hand cream on your hands as often as possible. Petroleum jelly — This jelly is typically thicker than hand cream and works well at filling in the cracks of your skin. Petroleum jelly also seals and protects your skin from further damage and helps lock in much-needed moisture. Liquid bandage — If your dry hands have cracked to the point that you are bleeding, consider using a liquid bandage. This product helps seal the cracks and hold them together as they heal, reducing the irritation and pain of cracked hands. You should not use liquid bandages in combination with other hand creams or moisturizing treatments. Exfoliation — For mildly cracked skin, you could try using a gentle exfoliating product to help remove the dead skin cells. This option is not recommended if your cracked skin is so bad that it is starting to bleed.
What do extremely dry hands look like?
You’ll likely feel dry hands before you really start to see signs of it. The skin may feel tight and itchy, or even a little painful, and start to look red. From there, you may notice your skin feels rough instead of smooth and is starting to flake or look scaly. A moisturizing hand cream can help relieve many of these issues if you use one regularly or as soon as you notice tight, red skin.
Why is my skin so dry even after I moisturize?
There are various reasons your skin is still dry even after moisturizing: Harsh ingredients — The moisturizer or hand cream you use may have drying ingredients like alcohols, sulfates, and fragrances. Switch to a better, more hydrating product with ingredients like hyaluronic acid, ceramides, and niacinamide. Not exfoliating — You need to regularly exfoliate your skin to remove dead skin cells and reveal newer skin. If you don’t, your moisturizing products can’t reach every part of your skin, leaving you with rough, dry patches. Not moisturizing enough — You should be moisturizing your skin twice a day, every day. If you aren’t, your skin will lose more moisture between each application, leading to drier skin.
What causes extreme dryness in hands?
Dry hands are most commonly caused by changes in temperature — such as going from warm to extreme cold weather — and constant handwashing, which can strip your skin of natural oils that protect the skin's barrier. Certain medical conditions can also result in severely chapped and rough hands. Genetics can also play a role in the condition of our hands, along with underlying health concerns or years of neglect of the delicate skin, especially on the back of our hands.
What can I do for severely dry hands?
Moisturize, moisturize, moisturize! The best hand creams for dry skin help lock in moisture and protect against dryness and cracking. In addition to using a moisturizing hand cream, you should exfoliate your hands at least once a week to help remove dead skin cells and encourage cell turnover. Additionally, you can: Wear sunscreen on your hands every day. Use gentle cleansers. Wash in warm — not hot — water. Wear gloves when cleaning or in cold weather