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Anti-aging on a global scale

Visible improvement and reduction of:

Pores - Wrinkles - Oiliness - Evenness - Pigmentation - Elasticity - Turgor - Water Loss (TWEL) - Visible Skin Thickening and Density

  • before and after
  • before and after
  • before and after
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DefenAge Clinical Power Trio "globally improves the visual appearance of aging skin... without irritation, inflammation or sun-sensitivity"

Journal of Drugs in Dermatology, 2018, 17(4): p. 426-441.
A. Taub MD, V. Bucay MD, G. Keller MD, et al.

Press Release ▶


Defensins sound like a miracle since they can do everything. Is it really true?

Yes, it is true and is actually proven in comprehensive clinical studies. WHY: Defensin-molecules promote new skin; young skin is always better than old skin in all of the above mentioned qualities.


Do not exceed recommended quantity of the product; more is not better.

Our formulas are designed with optimum concentration of defensins to produce results. Here is the number of pumps that we recommend:

8-in-1 BioSerum: 1 pump for the entire face, and 1 pump for the neck.

24/7 Barrier Balance Cream: 1 or 2 pumps for the entire face.

3D Eye Radiance Cream: 1 pump for the skin around both eyes.

Core Skincare Regimen

Clinical Power Trio

★★★★★ (154)

$14 - $318
with free account

DefenAge's signature Defensin-treatment

  • Corrects visible signs of skin exhaustion, damage and aging on a global scale.
  • Efficacy proven based on comprehensive clinical studies.
  • Initial results appear in the first week of use. The full range of results will appear within 6 weeks.
  • Award-winning


"Fantastic Skincare!

My dermatologist recommended DefenAge after she began using the products herself. I’m thrilled with the results I’ve seen after only a week! My skin is brighter and firmer. I’m so happy!"

Angie N.

Verified Buyer


"Excellent products

Even my husband who never seems to notice anything said my skin looks great."

Marsha H.

Verified Buyer


"I’m Surprised

Wasn’t sure what to expect since I’d never heard of this brand before.When I saw a doctor on TicTok talks about all the clinical research I had to try the Power Trio. I really see my fine lines have smoothed and diminished. And I especially appreciate how quickly it absorbs into my skin. It’s pricey yes, seeing results makes it worth it."

LuAnn P.

Verified Buyer

Try DefenAge!

See how much DefenAge’s signature skincare treatment can change your skin after just a few uses! Leave your contact information below and we will send an e-mail with trial details. Look for an e-mail with the subject line: "Try DefenAge!"

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