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DEFENAGE POWER PAIR
Anti-Aging Serum & Face Moisturizer
Visibly rejuvenate skin, reduce the appearance of fine lines and wrinkles, boost hydration, and enhance radiance
[ $296 value ]

San Diego Boat Show Exclusive

Sun, salt air, and time on the water. Your skin absorbs it all and already knows how to recover. DefenAge gives it the signal. 

27 % SAVINGS versus buying individually

Offer countdown timer

Valid through June 28, 2026. While supplies last.

DEFENAGE POWER PAIR

Anti-Aging Serum & Face Moisturizer
Visibly rejuvenate skin, reduce the appearance of fine lines and wrinkles, boost hydration, and enhance radiance
[ $296 value ]

San Diego Boat Show Exclusive

Sun, salt air, and time on the water. Your skin absorbs it all and already knows how to recover. DefenAge gives it the signal. 

27 % SAVINGS versus buying individually

Offer countdown timer

Valid through June 28, 2026. While supplies last.

$304.00
Claim Exclusive Rewards
SKU
10993-m
  1. Power Pair | Value Bundle | 4-8 week supply
  1. Fragrance Free

Skincare Anarchy AwardNEXT AwardELITE Lifestyle AwardInnovator Award

Elevate your skincare with DefenAge’s Power Pair—two of our best-selling, dermatologist-recommended products designed to hydrate, protect, and rejuvenate the look of the skin. Powered by Defensin-molecule technology, this duo works together to reduce the appearance of fine lines, boost moisture retention, and restore your skin’s youthful glow. Ideal for all skin types, this simple, effective routine delivers initial visible results within the first week of use.

Key Benefits:

  • • Age-Repair Defensins®: Triggers dormant skin cells to visibly reduce signs of aging.
  • • Moisture Lock: Keeps skin deeply hydrated while enhancing its natural barrier.
  • • Instant Radiance: Improves skin texture and luminosity for a glowing complexion.
  • • Simplicity, Maximum Impact: Perfect for those seeking an easy-to-follow routine that delivers powerful results.

Routine Contents:

  • • 8-in-1 BioSerum | Mega Size, 1.5 fl. oz.
  • • 24/7 Barrier Balance Cream | Full Size, 1.5 fl. oz.

All products in this collection are supplied in original individual packaging.

Made in the U.S.A.

How To Use

DIRECTIONS

 

24/7 Barrier Balance Cream

24/7 Barrier Balance Cream

Daily: AM | PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Suitable for all skin types.
Suitable for all skin types.

 

 

8-in-1 BioSerum

8-in-1 BioSerum

Daily: AM | PM

After applying 24/7 Barrier Balance Cream, place 1 pump of 8-in-1 BioSerum onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.

 

 

WARNINGS

For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

 

 

Clinical Studies

Study on Defensins and Skin Rejuvenation: What It Means for You

Background:

Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.

What are Defensins?

Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.

The Study:

  1. This was a double-blind, vehicle-controlled study, meaning neither the participants nor the researchers knew who was using the Defensin-containing product and who was using a placebo (vehicle).
  2. Participants included men and women with signs of skin aging, such as fine lines, wrinkles, uneven skin tone, and rough texture.
  3. They applied either the Defensin-containing product or a placebo product to their face for 6 weeks.

Key Results:

  1. Visible Improvement: Participants who used the Defensin-containing product showed significant improvement in skin quality compared to those who used the placebo. They experienced smoother skin, fewer wrinkles, improved texture, and a more even skin tone.
  2. Safety: The product was well-tolerated by participants, with no major side effects, making it a safe option for most people.

What This Means for You:

This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.

CLINICAL STUDY ►

Ingredients

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:

All formulas in this collection are fragrance-free.

CLEAN BEAUTY

We have carefully formulated our hand cream products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.

GREEN PLANET

The tubes and boxes are fully recyclable; please recycle.

Our products are not tested on animals.

Guarantees

QUALITY GUARANTEE

Quality guaranteed ONLY when sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 

 

MONEY BACK GUARANTEE

This product is qualified for the Money Back Guarantee.

In case of a refund, all products in this bundle should be returned.
Return Policy ►

 

FAQ's
No Questions

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.9418516 / 5 from 2700 reviews.

AI Generated Review Summary

Summary topics

Review topics: [results, improvement, wrinkles, scent, quality, feels, texture, price, value, skin, packaging, works, looks, face, pores, lines, compliments, glow, use, difference, duo, cream, skincare, serum, moisturizer, defenage, power pair, bioserum, combo, addition].

Review highlights

Reviews

So powerful must avoid during eyebrow tattoo and lip blushing

"This product works almost to well. Because of the effective cell turnover working so well and so rapidly, my permanent makeup artist has prohibited my Defenage for the 4 weeks following my tattoos. i miss the product and cant wait to get back to using it once my tattoos are fully healed."

— Betsy P. (5/5)

Game-Changer for my Skincare

"I've been using 8-in-1 Bioserum for years, and I'm so happy with the results. I used to have very visible sun damage on my neck and decollete, but this product has all-but-eliminated the redness and roughness. I feel so good using the 8-in-1 Bioserum with the 24/7 Barrier Balance Creme (plus the 2-Minute Reveal)."

— Christine M. (5/5)

Visible Results!

"My dermatologist recommended the 24/7 Barrier Balance Cream and 8-in-1 BioSerum. From the start of using these products, I could see and feel a big difference in my skin. I have waited a few months to review the products since I wanted to gauge the results over time. The products did not disappoint. My face is softer and smoother. Rough patches of skin have vanished. My skin tone has evened out and my pores are smaller. My skin's elasticity and firmness has improved, and my face feels a lot more supple and hydrated. I look younger and people are now complimenting me on how nice my skin looks."

— Kim B. (5/5)

Exceptional Product!

"The DefenAge 8-In-1 Bioserum delivers as promised. The serum goes on smooth and feels light and luxurious. It immediately softens the skin and makes it feel exceptionally smooth. Using the serum evened out my skin tone and reduced pore size. My face has more elasticity and my skin looks firmer. My skin looks and feels healthier than it has in years. That's saying a lot for someone who is in her late sixties! I can see why the 8-In-1 Bioserum is a top-selling product."

— Kim B. (5/5)

Love the ingredients

"I don't know that I am seeing results but I believe in the product and technology of the product. It doesn not mix well with some other products as it or the other products pills on my face so just try it on a small area of your face first. The only thing I don't like is the price. My husband freaks out at the amount of money I spend on skincare. Sales would be nice!"

— Marlene M. (4/5)

Definite Improvement!

"I'm 68 years old and like others have tried many skin treatment products over the years. Sometimes I see some improvement but often times none at all. Since using the Defenage Power Pair I am delighted to say that they actually work! The texture of my complexion is finer, smoother, and more supple, particularly around my mouth and chin which is a problem area for me. My vertical lip lines have softened - YAY! My skin feels good too. I had a random stranger compliment my complexion while standing in line at the grocery store this week which was an unexpected and delightful surprise. I thanked the woman and told her my age and she said, "Wow - you really wear it well. " What a confidence boost!"

— Lauren K. (5/5)

Love it!

"This is a great product; replaces several things I would otherwise be using (so overall a better value and faster to apply)"

— Travis W. (5/5)

Best moisturizer!

"I’ve used all different moisturizers and this one is perfect. Not at all greasy and works well under make up."

— Patti L. (5/5)

Impressed

"I’ve been using about three weeks and so far, so good. Gentle, slow results. My skin looks healthier, smoother, brighter. Less need for tinted anything coverage. Looking forward to seeing how far this takes my skin"

— Torie D. (5/5)

Great!

"Really love it! It fits so well with the cleanser and moisturizer - would definitely buy again! Not sure about full results yet as it's only been about a month, but it feels great!"

— Shannon P. (5/5)

Q&A