FLAWLESS FACE COLLECTION
A comprehensive facial care collection designed to hydrate, protect, and rejuvenate for luminous, youthful-looking skin.
[ $736 value ]

Prime-Like Savings

45 % SAVINGS compared to purchasing individually

Offer countdown timer

Valid through June 28, 2026. While supplies last.

FLAWLESS FACE COLLECTION

A comprehensive facial care collection designed to hydrate, protect, and rejuvenate for luminous, youthful-looking skin.
[ $736 value ]

Prime-Like Savings

45 % SAVINGS compared to purchasing individually

Offer countdown timer

Valid through June 28, 2026. While supplies last.

$736.00
Hall of Fame Award NewBeauty People en Español Star Product Skincare Anarchy 2025 NewBeauty Award Skincare Anarchy Award NEXT Award ELITE Lifestyle Award The BEST Neck Cream Award | NewBeauty Neck Cream Award | People Eye Cream Award | NewBeauty Best Brightening Mask Award Eye Cream Award Innovator Award Beautytap Award: Editor's Pick

Elevate your routine with the a complete set of skincare essentials. This all-in-one set includes everything needed for a complete face care regimen, from deep cleansing and targeted treatment to hydration, eye care, neck care, and lip enhancement. Powered by Defensin-molecule technology, each product works together to reduce the appearance of fine lines, improve skin texture, and restore a luminous, healthy glow—perfect for achieving your best skin yet this holiday season.

Key Benefits:

  • • Age-Repair Defensins®: Awakens dormant skin cells to visibly reduce signs of aging.
  • • Barrier-Boosting Hydration: Locks in moisture while strengthening the skin’s natural barrier.
  • • Full-Face Renewal: Targeted treatments that visibly restore vulnerable and problem areas.
  • • Simple, Powerful Skincare: Complete, results-driven skincare in one luxurious set.
  • • Defends Against Inflamm-aging: Helps combat hidden inflammation that accelerates visible signs of aging.

Routine Contents:

  • • 1-Step Multi-Cleanse (Mega Size, 5 fl.oz)
  • • 8-in-1 BioSerum (MEGA Size, 1.5 fl. oz.)
  • • 24/7 Barrier Balance Cream (Full Size, 1.5 fl. oz.)
  • • 2-Min Reveal Masque (Full Size, 2.5 fl.oz)
  • • 3D Eye Radiance Cream (Full Size, 0.5 fl.oz)
  • • 6-Week Perfection Neck Cream (1.5 fl.oz.)
  • • 12-Factor Revitalizing Lip Enhancer (Full Size, 0.25 fl.oz)
  • • NEW 7X Calming Complex (Full Size, 0.5 fl.oz.)

DIRECTIONS

 

STEP 1 - Cleanse & Exfoliate

1-Step Multi-Cleanse

1-Step Multi-Cleanse

Daily: AM | PM

Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops, then rinse with warm water or clean cloth.

 

 

2-Minute Reveal Masque

2-Minute Reveal Masque

Once or Twice Weekly

After cleansing, dry skin thoroughly. Apply a quarter-size dollop of masque to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly.

 

 

STEP 2 - Moisturize & Treat Targeted Areas

24/7 Barrier Balance Cream

24/7 Barrier Balance Cream

Daily: AM | PM

After cleansing or exfoliating, pump 1-2 pumps of cream onto fingertips. Lightly massage with fingertips over entire face. Avoid eye area.

 

 

3D Eye Radiance Cream

3D Eye Radiance Cream

Daily: AM | PM

Place 1 pump of cream onto fingertips. Dab three dots of cream below each eye and lightly massage with the gold tip applicator. If not applying eye makeup, continue to apply to the upper eyelid, but avoid contact with eyes and eye lashes.

 

 

6-Week Perfection Neck Cream

6-Week Perfection Neck Cream

Daily: AM | PM

Place 1-2 pump of neck tightening cream onto fingertips. Starting above the breast line and working up, lightly massage cream onto the décolleté, neck, and back of the neck with short, upward-lifting motions.

 

 

7X Calming Complex

7X Calming Complex

Daily: AM | PM for 10-14 days or until tube is empty.

Apply a pea-sized amount of serum to your fingertips and gently massage onto the face using light, upward motions. For the neck and décolleté, dispense an additional drop and smooth evenly. This cosmetic treatment can be repeated 4–6 times per year to help calm, restore, and maintain balanced skin.

 

 

STEP 3

8-in-1 BioSerum

8-in-1 BioSerum

Daily: AM | PM

Wait 30 seconds after applying 7x Calming Complex, then apply a pea-size amount of serum onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second drop on neck and décolleté. Follow with sunscreen.

 

 

STEP 4 - Finishing Product

Lip Revitalizing Lip Enhancer

Lip Revitalizing Lip Enhancer

Daily: AM | PM

With the cap on, shake the bottle well before first use. Hold the bottle at the indented areas with 2 fingers. Push down on both sides of the applicator to release a drop of the serum. Use the tip of the applicator to smooth one pump over the lips.

 

 

WARNINGS

For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

 

 

Study on Defensins and Skin Rejuvenation: What It Means for You

Background:

Researchers conducted a multi-center, double-blind clinical trial to evaluate the effects of a skincare product containing alpha and beta Defensins—special molecules known for their role in skin healing and renewal. The goal was to see how effective these molecules are at rejuvenating aging skin.

What are Defensins?

Defensins are natural molecules found in the body, typically known for their role in immune defense. In this trial, they were tested for their ability to activate dormant skin cells (LGR6+ stem cells) to help generate new, healthy skin.

The Study:

  1. This was a double-blind, vehicle-controlled study, meaning neither the participants nor the researchers knew who was using the Defensin-containing product and who was using a placebo (vehicle).
  2. Participants included men and women with signs of skin aging, such as fine lines, wrinkles, uneven skin tone, and rough texture.
  3. They applied either the Defensin-containing product or a placebo product to their face for 6 weeks.

Key Results:

  1. Visible Improvement: Participants who used the Defensin-containing product showed significant improvement in skin quality compared to those who used the placebo. They experienced smoother skin, fewer wrinkles, improved texture, and a more even skin tone.
  2. Safety: The product was well-tolerated by participants, with no major side effects, making it a safe option for most people.

What This Means for You:

This study suggests that skincare products with Defensins can effectively help to rejuvenate aging skin by stimulating your skin’s natural renewal process. If you're looking for a beauty solution that works at a deeper, cellular level, Defensin-powered products like the ones from DefenAge could be a great addition to your skincare routine.

CLINICAL STUDY ►

Please review the key performance ingredients and detailed ingredient lists on the individual product pages:


CLEAN BEAUTY

We have carefully formulated our products to exclude multiple harmful and questionable ingredients. Please visit our Clean Beauty page for more details.


QUALITY GUARANTEE

Quality guaranteed ONLY when items are sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources.

 

MONEY BACK GUARANTEE

This product is qualified for the Money Back Guarantee.

Return Policy

 

No Questions

FREQUENTLY BOUGHT TOGETHER

Overall rating: 4.923798 / 5 from 4908 reviews.

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Reviews

Excellent!!

"I have been using this product for almost a year now, and the difference it makes is amazing, the cleaner takes all the make up off in one washing. I have used other products as well and the skin on my face and neck have shown remarkable results. This is a must for your facial routine"

mary s. (5/5)

It’s a keeper

"All of your products are great. Easy to use because there aren’t 20 things that you have to remember what they’re for. The daily routine is simple. Everything smells good without being perfumed. I’ve used the basic trio for over 10 years. Periodically I’ve tried other things and I always come back. People often say what potion am I using. It must be you guys."

Mimi O. (5/5)

So powerful must avoid during eyebrow tattoo and lip blushing

"This product works almost to well. Because of the effective cell turnover working so well and so rapidly, my permanent makeup artist has prohibited my Defenage for the 4 weeks following my tattoos. i miss the product and cant wait to get back to using it once my tattoos are fully healed."

Betsy P. (5/5)

Necessary!

"If you microneedle at home or use stronger exfoliants (esp chemical peel type), this is a great post-treatment to help calm and repair skin damage. It is a noticiable improvement overnight and helps keep the redness and dryness at bay."

Travis W. (5/5)

Love the pump and smoother skin

"With a long next and décolletage it’s great to feel comfortable in my skin. We all know that our neck adds years if not cared for. I’ve never experienced any product that actually smooths my skin as well as the 6 Week Perfection Neck Cream. I stopped using it for a while and quickly noticed the difference when I added it back into my skincare routine. . it’s a much needed help for mature skin."

Jan H. (5/5)

Game-Changer for my Skincare

"I've been using 8-in-1 Bioserum for years, and I'm so happy with the results. I used to have very visible sun damage on my neck and decollete, but this product has all-but-eliminated the redness and roughness. I feel so good using the 8-in-1 Bioserum with the 24/7 Barrier Balance Creme (plus the 2-Minute Reveal)."

Christine M. (5/5)

Eyes Wide Open!

"I've been using the 3D Eye Radiance Cream for about 6 weeks now and the skin under my eyes is not only lighter and brighter but less pouchy/baggy. The improvement means that I'm needing less under eye concealer, and a few times I've skipped it entirely. My upper lids have also improved with a more taut, sculpted look and less "overhang". I've had no sensitivity issues with the 3D Eye Radiance Cream either. At 68 years old I am beyond pleased with the results!"

Lauren K. (5/5)

My favorite face wash!

"One of my favorite products. I've been using this face wash for about 2 years and I have clearer skin, my makeup comes off easily, and my pores are smaller."

Catherine H. (5/5)

Wonderful Mask!

"The DefenAge 2-Minute Reveal Masque is one of my favorite products. It does a wonderful job of gently exfoliating the skin. Afterwards, my face feels soft and smooth and has a glow to it. Using the masque at least once a week enhances the results of the other DefenAge products for me."

Kim B. (5/5)

Exceptional Product!

"The DefenAge 8-In-1 Bioserum delivers as promised. The serum goes on smooth and feels light and luxurious. It immediately softens the skin and makes it feel exceptionally smooth. Using the serum evened out my skin tone and reduced pore size. My face has more elasticity and my skin looks firmer. My skin looks and feels healthier than it has in years. That's saying a lot for someone who is in her late sixties! I can see why the 8-In-1 Bioserum is a top-selling product."

Kim B. (5/5)

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