10 LUXE HAND AND BODY CREAM
10 Luxe Hand and Body Cream, 10 oz

New 10 oz Option Coming Soon

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10 LUXE HAND AND BODY CREAM

10 Luxe Hand and Body Cream, 10 oz

New 10 oz Option Coming Soon

Sign up for emails to be the first to know. Join our list.

$138.00
Out of stock
Good Housekeeping Award: Best in Best-in-Class Body

Anti-Aging Body Lotion Details

A new study published in the Journal of Cosmetic Dermatology (2022) says that this 10 Luxe Hand & Body Cream improves overall skin quality. Please visit the Clinical Studies tab for more details.

If you ever mused aloud, "I wish I could slather my entire body with DefenAge," then the 10 Luxe Hand & Body Cream is an anti-aging hand cream that answers your call. According to key opinion leaders in aesthetic medicine, our regenerative anti-aging body lotion for crepey skin delivers much more than a product that simply feels soft to the touch. Expert opinions

This innovative anti-aging body cream and hand lotion is the best body lotion for aging skin because it:

  • •  Visibly enhances firmness and cosmetic elasticity.
  • •  Improves the appearance of crepey skin.
  • •  Refines the surface skin texture.
  • •  Provides both instant and long-lasting hydration including in dry climates. Boosts natural moisture retention. Skin feels firmer and plumper immediately.
  • •  Relieves the feeling of dryness and itching.
  • •  Balances the skin’s barrier function.
  • •  Promotes the skin’s natural hyaluronic acid, laminin, and elastin.
  • •  Improves visible skin thickness.
  • •  Reverses signs of skin aging, premature aging, and sun damage.
  • •  Effective on elbows and knees; visibly revives their smooth texture and revitalizes softness.

When used as an anti-aging hand cream, this product smooths and softens the skin on the hands and keeps skin glowing all over the body. This lotion for aging skin is beneficial in combination with body-contouring procedures to improve visible skin firmness and overall skin quality. We recommended pairing our firming body cream with skin rejuvenation treatments (i.e., peels, IPL, microneedling, and lasers) to amplify results in reducing the look of pigmentation, sun damage crepiness, and mild skin laxity.

Why Our Anti-Aging Hand Cream Is Different

The DefenAge anti-aging body lotion and hand cream has been formulated with Defensin molecules. Our science-backed skincare products encompass seven years of knowledge and research collected on the clinical performance of Defensins compared to retinol-based anti-aging body cream. The DefenAge 10 Luxe Hand and Body Cream has become the best body lotion for aging skin because it:

  • •  Provides anti-aging benefits on a global scale.
  • •  Promotes newer, younger skin.
  • •  Effective on both the hands and body.
  • •  Fast-acting; first results appear immediately to one week after the first use, with the full range of results becoming visible in six weeks.
  • •  Non-irritating retinol alternative; delivers retinol-like results.
  • •  Rich, luxurious texture, elegant feel, clean smell of natural ingredients, and fragrance-free.
  • •  Absorbs quickly and is not sticky, tacky, or greasy.
  • •  Four-pillar formulation strategy:
    • ◦  Global anti-aging (defensin-molecules)
    • ◦  Natural moisturization & comprehensive barrier repair (Ophiopogon japonicus root extract, Sinorhizobium meliloti ferment)
    • ◦  Soothing & calming via anti-inflammation (panthenol)
    • ◦  DefenAge’s hero blend of ingredients proven to be well-paired with defensins (including niacinamide and squalane)
  • •  Advanced clean beauty standards; no PEGs or animal- or human-derived ingredients.
  • •  Developed in response to demand by the medical community, aesthetic service providers, and customers.

This firming body cream is and always will be made in the U.S.A.

Opinions and Stories

DefenAge Unveils First-Ever Anti-Aging Body Cream Containing Defensin-Molecules

Carlsbad, CA – September 01, 2021 – DefenAge® Skincare, manufacturer and distributor of revolutionary, evidence-based, anti-aging products, today announces the launch of its long-awaited 10 Luxe Hand & Body Cream, developed in response to the demand by aesthetic medical professionals and customers. Infused with DefenAge’s famed and exclusive defensin-molecules, the new hand and body cream bathes skin in the most powerful age-reversal skincare technology on the market. Read more...

How to Use Our Hand and Body Lotion

DIRECTIONS

10 Luxe Hand & Body Cream | Anti-Aging Firming Lotion

STEP TWO - BODY | 10 Luxe Hand & Body Cream 

AM | PM Directions

Once or twice daily, smooth onto skin as desired. For enhanced results, apply DefenAge 8-in-1 BioSerum to elbows, knees, back of hands and other targeted areas.

This is the best body lotion for all skin types.


WARNINGS

Hand and body cream is for external use only. Keep out of your eyes. If the product enters the eyes, rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.

Clinical Studies

The 10 Luxe Hand & Body Cream is tested by a Board Certified Dermatologist and shows an outstanding safety profile.

The new peer-reviewed clinical study shows the high-performance of the 10 Luxe Hand & Body Cream in global skin improvement. The study has been published in the Journal of Drugs in Dermatology (2022), the article is titled “Impact of Defensins-Containing Body Cream on Skin Composition”. In the study, participants reported significant improvement across all tested skin sites, including challenging skin areas such as the elbows, knees, forearms, and hands. The objective clinical measurements also demonstrated outstanding improvement in a variety of skin qualities, including improvement in cosmetic elasticity, hydration, and visible collagen stimulation when the body cream was applied daily for six weeks. Read the press release here or visit the Journal of Cosmetic Dermatology to review the full study.

10 Luxe Hand & Body Cream | Before and After

Before and after 6-week study period photographs of pre- and post-elbow of participant #5. https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.15118

REFFERENCE:

  1. Eggerstedt M, Torres-Maldonado S, Danielian A, Hwang SHJ, Echanique KA. Impact of defensins-containing body cream on skin composition. J Cosmet Dermatol.. 2022 May 27. doi: 10.1111/jocd.15118. PMID: 35621235.

Robust Multi-Function Anti-Aging Body Lotion

"I love it. It is rich, and penetrates well, and I love that the pump gives you a lot in one draw. Most anti-aging body creams just make a simple lotion and add their hero ingredient. By creating a body cream with barrier repair and anti-inflammatory ingredients in addition to defensins, the 10 Luxe Hand & Body Cream gives me confidence I am recommending the very best anti-aging body cream to my patients due to its robust multi-function."

- Dermatologist Amy Forman Taub, MD

"The new DefenAge body cream addresses an unmet need in the beauty industry. It has the same evidence-based science as the legacy products. It takes advantage of anti-aging ingredients paired with the defensin-molecules to revive aging skin."

- Dermatologist Sue Ellen Cox, MD

"I’m a surgeon and wear sterile gloves for hours. My hands and fingers often become irritated. Use of the new 10 Luxe Hand & Body Cream has relieved the irritation and left my hands soft and smooth."

- Plastic Surgeon Gregory Keller, MD

Crepey Skin | Study

"Our patients have been waiting for a topical solution to address crepey skin that actually does more than a store-bought moisturizer. I finally have a scientifically proven option with DefenAge’s 10 Luxe Hand & Body Cream. In our split inner arm and lower thigh testing, patients have seen a difference on the treated side within 2 weeks that continues to improve over the next 12 weeks."

- Dermatologist Suneel Chilukuri, MD

"So many patients are complaining about creping changes to their arms and legs, and while previously I suggested they use a pump of DefenAge 8-in-1 BioSerum mixed with their favorite body lotion, the new body cream will encourage the use of body-specific products instead of trying to fit facial products on body areas."

- Dermatologist Steven Swengel, MD

"After trying the 10 Luxe Hand & Body Cream, my dry skin instantly looks and feels better; it is perfect for crepey skin, especially in a dry climate. The defensin-based technology can actually reverse the appearance of aging skin, so much so that areas that might otherwise be covered, such as the upper arms, elbows and knees, can now be exposed again. The texture is perfect, thick enough without feeling too heavy. Application is smooth without feeling greasy.I plan to pair the 10 Luxe Hand & Body Cream with BBL Hero (Sciton) treatments. The device by Sciton can reduce pigment, sun damage, crepiness, and mild skin laxity in a manner similar to using DefenAge post microneedling. The thermal effect of the device on skin will be amplified by the post-treatment application of the DefenAge body cream. I plan to instruct patients to use the 10 Luxe Hand & Body Cream two to three times a day following four weekly treatments with the BBL."

- Plastic Surgeon Diane Duncan, MD

'Immediate' Effect

"I am thrilled to introduce the 10 Luxe Hand & Body Cream to my patients. The feeling is elegant. The smell is pleasant and clean. It absorbs fairly quickly and is not at all sticky or tacky. It moisturizes, hydrates, and immediately, the skin feels firmer and plumper. I only recommend skincare products that are backed by science. All DefenAge products, including the new body cream, contain ingredients that are clinically proven to rejuvenate, hydrate, and brighten skin."

- Dermatologist Melda Isaac, MD

Elbows and Knees

"The defensin-based technology can actually reverse the appearance of aging skin, so much so that areas that might otherwise be covered, such as the upper arms, elbows, and knees, can now be exposed again."

- Plastic Surgeon Diane Duncan, MD

"Being almost 60, with gardening as a hobby, kneeling and using my gardening tools caused my knees and arms to become rough and almost ‘calloused.’ I saw a dramatic improvement in my crepey skin and roughness just a few days after I started using DefenAge’s new body cream. There is no doubt that I will recommend my patients to use the 10 Luxe Hand & Body Cream on their elbows and knees, who are already asking how I got such an improvement."

- Partner at Keller Plastic Surgery Pamela Keller, RN

Safe Retinol Alternative for Hands and Body

Dermatologist Stephen Friedman, MD, of Malibu, California, conducted a dorsal arm bilateral comparison of the 10 Luxe Hand & Body Cream to an advanced retinol-containing body lotion, additionally supplemented with hydrating and barrier repair ingredients. Dr. Friedman concluded that DefenAge’s new body cream produced comparable clinical benefits to the retinol lotion. “In the brief open clinical trial, there is no perceptible difference in the appearance of the right and left dorsal arms. The degree of hydration, texture, and color were identical.”

- Dermatologist Stephen Friedman, MD

Pairs With Body Contouring Procedures And Skin Rejuvenation Treatments

"The non-surgical body contouring industry is increasing significantly. The 10 Luxe Hand & Body Cream with defensin technology has been shown to improve the quality of the skin long after we reduce the patient’s fat and tone their muscle. Defensins help us to ‘ice the cake’ on the patient’s overall quality of the result. It has been a welcome addition to my armamentarium of body treatments. It also fits into our new ‘biostimulatory’ story for skin improvement. I have been using defensin technology in my offices since the inception of DefenAge. My patients made me a believer, as without exception any patient who uses DefenAge sees an improvement in the tone, quality, and clarity of their skin."

- Facial Plastic and Reconstructive Surgeon Gregory Chernoff, MD

"The new DefenAge 10 Luxe Hand & Body Cream is a very exciting addition to this incredibly luxurious and effective line of skincare products. Like the face and neck products, the body cream contains the coveted defensins in addition to a strong lineup of active ingredients to target stubborn crepey skin on the body, while enriching the skin barrier and providing excellent emollition. When used alongside radiofrequency microneedling, such as Cutera Secret RF, which is one of my go-to procedures for firming and resurfacing of arms, legs, abdomen, and more, the DefenAge body cream ingredients add anti-aging benefits while simultaneously ameliorating the healing process. I cannot wait to offer this innovative product to my patients."

- Dermatologist, Jessica Weiser, MD

This Anti-Aging Hand Cream Is a Must-Have Product

"We consider DefenAge an essential skincare product. The new 10 Luxe Hand & Body Cream is a wonderful addition that we will all be using! It has a great texture, is an excellent moisturizer, and improves both the sun damage and aging part of our skin."

- Dermatologist Angela Bowers, MD

"DefenAge has been working on developing, improving, and refining defensin skincare technology over the last 7 years. I have had the pleasure of being not only a happy consumer of all of their products, but also a board-certified cosmetic dermatologist who has seen the entire product line grow with impressive product after product with cutting-edge technologies that I have had the pleasure of sharing with many patients who have benefited from this exclusive skincare. From the face to the eyes to the neck and décolleté, DefenAge has changed the way we view the possibilities for topical skincare, and similarly the way in which we see ourselves every day in the mirror. The time has arrived to ‘turn the clock back’ with DefenAge on aging hand and body skin just as we have been doing already with other DefenAge products on our faces, eyes, and neck. After reviewing the science, it is easy to understand why DefenAge’s new hand and body cream feels great when applied to the skin, relieves dryness and itching (even in dry, sensitive skin like mine), and enables moisturization that lasts and lasts while contributing to anti-aging and improving the look and feel of the skin itself. It is with great enthusiasm that I welcome the 10 Luxe Hand & Body Cream. For many of us… it has been a long-awaited arrival!"

- Dermatologist Natalie M. Curcio, MD, MPH

"My patients are looking for effective anti-aging solutions for the face and the body. With the new DefenAge body cream, they have an option that goes beyond typical moisturizers to improve the appearance of their skin and help to reverse the aging process."

- Dermatologist, Anne Chapas, MD

"DefenAge’s Body Cream meets the long-awaited need for a body cream that is both an effective anti-aging product as well a luxurious, feel-good product. The addition of this cream to the curated products aesthetic practices carry in-house is a must"

- Aesthetic Physician, Monica Bonakdar, MD

Advanced Hand and Body Skincare

"The future of Aesthetics is regenerative medicine, and this includes new advances in skincare products. DefenAge’s new body cream reprograms your dormant cells to create new skin cells from head to toe. My skin is now mainly comprised of young cells,and it shows."

- Dermatologist Shino Bay Aguilera, MD

"As a dermatologist who strives to care for both the medical and cosmetic concerns of my patients, good skincare is not limited to the face and neck. It includes the entire body. An ingredient and evidence-based approach to skincare makes sense to me and allows me to explain the benefits of a particular product to my patients. Several years ago, I became a fan of DefenAge, an innovative skincare line that leverages defensins, molecules that have the ability to stimulate a subset of dormant stem cells to create a more youthful epidermis. A few months ago, I had the opportunity to try DefenAge’s 10 Luxe Hand & Body Cream, which feels very lightweight and absorbs quickly while still delivering long-lasting hydration. What really appeals to me are the 4 pillars that are the foundation of the formulation: anti-aging on a global scale provided by defensins; hydration and barrier repair by Ophiopogon japonicus root extract and Sinorhizobium meliloti ferment; soothing and calming by panthenol; and a hero blend of ingredients that are compatible with defensins, including niacinamide (aka multitasking vitamin B3 that plays a key role in skin immunology, barrier function, and pigmentation, to name a few) and squalane"

- Dermatologist Vivian Bucay, MD

Source: Backed by Science, New Body Cream Redefines Expectations of Aesthetic Medical Professionals | Dermatology Times 

Anti-Aging Body Cream Ingredients

Key Performance Ingredients & Technologies

Age-Repair Defensins® | DefenAge's Exclusive

• Promotes new skin • Anti-aging on a global scale • Retinol alternative •

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. The DefenAge hand and body lotion contains an identical copy of human defensins made via bio-synthesis; Defensins are exclusive to DefenAge.

Niacinamide

• Firmness & Elasticity • Brightening • Hydration •

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone. It is a part of DefenAge's hero blend of ingredients that are well-established to work together with defensins.

Fine Blend of Soothing and Calming Ingredients

• skin calming & soothing •

This product is infused with a powerful and concentrated composition of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.

Ophiopogon Japonicus Root Extract and

Sinorhizobium Meliloti Ferment

• Skin's barrier balance • Natural hydration

The “know-how”-protected, advanced, and powerful blend of natural extracts in our firming body cream balances the skin’s barrier, saves the skin’s natural moisture, and promotes the levels of Natural Moisturization Factors (NMFs).

Squalene

• Moisturization • Antioxidant •

This ingredient enhances skin hydration and prevents moisture loss while restoring visible skin’s suppleness and flexibility. It fights skin damage and free radicals.

Panthenol

• Soothing • Protection •

Panthenol helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. It hydrates the skin from within and is a proven humectant.


CLEAN BEAUTY

This hand and body lotion formula exceeds most, if not all, industry and beauty standards for clean skincare. In addition to the extended list of ingredients that are restricted for use in DefenAge, the 10 Luxe Hand & Body Cream also does not contain silicones or PEGs, and it is free from fragrance. To learn more about DefenAge’s clean skincare standards, please visit our Clean Beauty page.


GREEN PLANET

The bottle and box of our anti-aging hand cream are fully recyclable, so please recycle.

Our hand and body lotion is never tested on animals.


FIRMING BODY CREAM INGREDIENT LIST

10 Luxe Hand & Body Cream

Water (Aqua), Aloe Barbadensis Leaf Juice, Butyrospermum Parkii (Shea) Butter, C13-15 Alkane, Caprylic/Capric Triglyceride, Propanediol, Sinorhizobium Meliloti Ferment Filtrate, Niacinamide, Cetyl Alcohol, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Stearyl Alcohol, Simmondsia Chinensis (Jojoba) Seed Oil, Squalane, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Tetrahexyldecyl Ascorbate, Ophiopogon Japonicus Root Extract, Tocopheryl Acetate, Panthenol, Kappaphycus Alvarezii Extract, Caesalpinia Spinosa Fruit Extract, Ubiquinone, Albumin, l-Alanyl-L-Glutamine, Palmitic Acid, Sodium Stearoyl Glutamate, Glycerin, Methyl Glucose Sesquistearate, Polyacrylate Crosspolymer-6, Cetyl Hydroxyethylcellulose, Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Phytic Acid, Sodium Phytate, Caprylhydroxamic Acid, 1,2-Hexanediol, Sorbic Acid, Sodium Chloride.

Firming Body Cream Guarantees

QUALITY GUARANTEE

Our quality is guaranteed ONLY when the 10 Luxe Hand & Body Cream is sold by defenage.com or authorized professionals. Otherwise, it may be counterfeit, black market, old, or improperly stored or handled.

The quality of our products is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources.

MONEY-BACK GUARANTEE

10 Luxe Hand & Body Cream is qualified for the Money-Back Guarantee.

Return Policy ►
How quickly are results visible with the 10 Luxe Hand and Body Cream?
Skin feels firmer and more hydrated from the very first use, with visible results building from there. The first noticeable changes typically show up within a week, and the full range of results, including improvements in texture and firmness, comes through by six weeks of consistent use.
What makes the 10 Luxe Hand and Body Cream different from other body creams?
The 10 Luxe Hand and Body Cream is built around Age-Repair Defensins, the same technology behind DefenAge's face and neck products, now formulated for hands and body. Four pillars shape the formula: global anti-aging from the defensins themselves, barrier repair and natural moisturization from Ophiopogon japonicus root extract and Sinorhizobium meliloti ferment, soothing botanicals like panthenol, and a hero blend of niacinamide and squalane known to work well alongside defensins. It's a gentle, non-irritating alternative to retinol, absorbing quickly into a rich texture that never feels greasy on hands or body.
What are the key benefits of the 10 Luxe Hand and Body Cream?
The 10 Luxe Hand and Body Cream visibly firms and smooths the look of crepey skin while delivering both instant and long-lasting hydration, even in dry climates. It relieves the feeling of dryness and itching, balances the skin's barrier, and supports the skin's natural hyaluronic acid, laminin, and elastin. Over time it improves visible skin thickness and helps reverse signs of aging and sun damage, all while keeping skin feeling soft and glowing from hands to body.
Can the 10 Luxe Hand and Body Cream be used on both hands and body, including the neck and face?
Hands, arms, elbows, knees, and the rest of the body are all fair game for the 10 Luxe Hand and Body Cream, and the neck works well too. For the face, the 8-in-1 BioSerum and 24/7 Barrier Balance Cream remain the better fit, formulated specifically for facial skin.
Can I layer the 10 Luxe Hand and Body Cream with other products?
Layering the 10 Luxe Hand and Body Cream into an existing routine works beautifully, and results build even further with the 8-in-1 BioSerum added to elbows, knees, and the backs of the hands. Once or twice daily fits naturally into a morning and evening rhythm, with Defensin-molecules working alongside whatever else is already part of the routine to support noticeable improvement in tone, texture, and radiance. Sunscreen stays part of the daytime routine too, protecting all that progress along the way.
Are there enough Defensins in this formula to actually make a difference?
The 10 Luxe Hand and Body Cream contains the same Alpha-Defensin 5 and Beta-Defensin 3 technology used across DefenAge's face and neck products, built on seven years of research into how defensins perform compared to retinol. A 2022 study published in the Journal of Cosmetic Dermatology confirmed the cream improves overall skin quality, backing up what the formula delivers. Specific concentration levels stay proprietary across all DefenAge products, with clinical results doing the talking instead. Consistency matters most here, since the defensins work by activating the skin's own dormant cell reserves, with visible changes typically appearing within a week and the fuller range by six weeks.
Is the 10 Luxe Hand and Body Cream safe to use during pregnancy?
The 10 Luxe Hand and Body Cream was designed with clean beauty in mind, fragrance free and free from retinols along with many of the ingredients most commonly flagged during pregnancy. That said, formal clinical studies specifically evaluating safety during pregnancy or breastfeeding haven't been conducted, so consulting the ingredient list with an OB-GYN first is the safest way to know for sure. The full ingredient list is available on this page, and more on DefenAge's clean beauty standards can be found on the Clean Beauty page.
Will the 10 Luxe Hand and Body Cream help with sagging skin from weight loss?
Loose, crepey skin responds well to the 10 Luxe Hand and Body Cream, with Age-Repair Defensins supporting the skin's natural renewal and shea butter and barrier-repair ingredients restoring hydration and texture. For more significant skin laxity following major weight loss, pairing this cream with a body contouring procedure tends to bring the best results, with the cream supporting overall skin quality and firmness alongside whatever treatment is chosen.

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