7 Reasons to Try DefenAge
Try the complete regimen and see first results as soon as within the first week.
$69Introductory offer$167 if purchased separately.
Discover Your New Skin
- Proprietary Age-Repair Defensins®
- U.S. Patents No. 11,491,096 & 11,020,452
- 4.9 stars from 3,651 reviews
- Free U.S. shipping
- 45-day money-back guarantee
- Proven in clinical studies
- Made in the U.S.A.
Seven reasons to start with the Renew & Reveal Discovery Collection.
The regimen is proven in comprehensive clinical research, rated 4.9 stars from more than 3,600 reviews, and works through your body’s own regenerative biology.
- 1Unique patented mechanism. Addresses multiple signs of aging simultaneously
- 2Proven in rigorous clinical studies
- 3Real results you can see, and others notice
- 4First results as soon as within the first week
- 5People like you love it
- 6A simple routine
- 7A complete regimen for $69, with a 45-day guarantee
Unique patented mechanism. Addresses multiple signs of aging simultaneously.
“The skin hasn’t lost its ability to renew. It’s lost the signal to start.”
Dr. Jessica Weiser, dermatologist
- 1Your skin knows how to renewThis anti-aging regimen works with your body’s own regenerative biology. Every time a small scratch heals, your skin makes new skin that looks younger than the skin around it, because your skin always knows how to renew. It just needs to get a signal. Defensins in DefenAge are that signal: they message your body through the same wound-healing biology, without a scratch.
- 2DefenAge brings the signal to your routinePatented Age-Repair Defensins® in 8-in-1 BioSerum and 24/7 Barrier Balance Cream are bio-synthesized copies identical to two human defensins.
- 3Your skin shows the renewalThe result is visible improvement across multiple signs of aging, studied in a randomized, placebo-controlled clinical trial.1
Proven in rigorous clinical studies.
In the published trial, 41- to 71-year-old women used a three-product regimen and their results were measured against a placebo.1 All three products, 8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque, are part of this collection.
“Globally improves the visual appearance of aging skin.”
“…offers most of the advantages of time-honored retinols without irritation, inflammation, or sun-sensitivity.”
Improvement in skin evenness, reduction in the appearance of visible pores, wrinkles, and pigmentation, plus normalization of skin oiliness.
Peer-reviewed and published in the Journal of Drugs in Dermatology. Read the study
5Significant improvement versus placebo simultaneously in 5 major signs of skin aging including the appearance of superficial and deep wrinkles, visible pores, pigmentation and epidermal quality.1
92%of customers experienced results2
Real results you can see, and others notice.
Unretouched photos. Drag the line to compare.
Baseline 12 weeks 
Baseline 4 weeks 
Baseline 7 months 
“Last night I played tennis against someone I’ve not seen for awhile and she kept telling me how young I looked. I’m 67…”
“I have been using all of the Defenage product line for a few months now. I love it. I have had several girlfriends ask what I am using; the results are noticeable.”
First results as soon as within the first week.
Any scratch or cut on the skin heals within 7 days. That means your body can produce meaningful visible results within just 7 days.
DefenAge’s defensins use the same regeneration biology to visibly rejuvenate the skin.
Your first 14 days to renewed skin.
Discover what your skin can experience with DefenAge.
From your very first application to the first signs of visible renewal, explore how our patented Age-Repair Defensins® and Renew & Reveal Collection help reveal smoother, firmer, more radiant-looking skin.
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Day 1
Your renewal begins.
Feel the difference
Your first step toward renewed skin starts today. Experience immediate hydration as your skin feels softer, smoother, and more comfortable.
What to look forSkin that feels hydrated, nourished, and refreshed.
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Day 3
The glow begins.
Your skin is getting started
As you continue your routine, your skin may begin to feel smoother, softer, and more supple. Your journey toward visible skin renewal is underway.
What to look forImproved softness, hydration, and a healthy-looking glow.
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Day 7
The first visible changes.
See the difference
Initial visible results may begin appearing after just one week. Look for improvements in skin texture, radiance, and overall appearance as your skin’s natural renewal process is supported.
What to look forSmoother-looking texture, improved radiance, and a more refreshed complexion.
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Day 14
Your skin renewal journey.
Imagine what’s next
Two weeks into your DefenAge experience, you may begin noticing a smoother, more radiant-looking complexion. And this is just the beginning.
What to look forContinued improvements in the appearance of skin texture, softness, and radiance.
Beyond day 14: the best is yet to come.Your Renew & Reveal Discovery Collection is just the introduction. Continue your DefenAge routine to experience the full range of visible improvements in as little as six weeks, including the appearance of fine lines, wrinkles, firmness, and skin texture.
Discover Your New SkinPeople like you love it.
97%would purchase DefenAge again2
94%are satisfied with their results2
“I faithfully use the masque, barrier balance cream, and BioSerum. My skin is much softer and brighter after only a few weeks of use. I am having many compliments on how my skin looks.”
“I’m only 2 weeks in to the regime, but I’m already noticing my pores are smaller and I’ve had 2 compliments on my skin from friends that don’t know I’ve started using something new, so… EXCITED!!!”
“After using 8 in 1 and Barrier cream, my husband tells me my skin looks great! Love that : ). I’m a 68 yo.”
“I am a new user to this line, but have been very impressed with the results! Even my husband has asked what I am doing.”
Multiple innovation awards from the most trusted beauty voices
As featured in
A simple routine.
Three easy steps, plus a 2-minute masque once or twice a week.
Step 1Cleanse1-Step Multi-Cleanse- Step 2Hydrate24/7 Barrier Balance Cream
- Step 3Renew8-in-1 BioSerum
- 1 to 2 times a weekReveal2-Minute Reveal Masque
A complete regimen for $69. No subscription, free shipping, 45-day money-back guarantee.
Renew & Reveal Discovery Collection
Core age-repair regimen, two-week supply · Fragrance Free
Try the complete, clinically studied regimen for two weeks. Includes a full-size cleanser and our Signature Bag as a gift.
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Free U.S. shipping · 45-day money-back guarantee · Made in the U.S.A.
- Core age-repair regimenTwo-week supply of 24/7 Barrier Balance Cream, 8-in-1 BioSerum and 2-Minute Reveal Masque
- Full-size 1-Step Multi-CleanseStep 1 of your routine, morning and night
- DefenAge Signature Bag, our giftKeeps your regimen together
We stand behind our products, and we are confident in their quality, performance and results. That is why your order is backed by our 45-day money-back guarantee. Two weeks gives you time to feel the routine.
$4.93a day for the two-week regimen, with a full-size cleanser and our Signature Bag included.
“Great starter! Bought this to try the product before purchasing full size. Skin improved in the first week of using the products as instructed. Have now purchased the entire collection to try.”
Before you decide.
What is in the Discovery Collection?
The core age-repair regimen in a two-week supply (24/7 Barrier Balance Cream, 8-in-1 BioSerum and 2-Minute Reveal Masque), a full-size 1-Step Multi-Cleanse, and the DefenAge Signature Bag as our gift.
How do I use it?
Cleanse, then apply the 24/7 Barrier Balance Cream and the 8-in-1 BioSerum, morning and night. Use the 2-Minute Reveal Masque once or twice a week.
How long does the regimen last?
The regimen is a two-week supply, which gives you two weeks to feel the routine. The cleanser is full size.
Has the regimen been studied?
A randomized, double-blind, placebo-controlled trial of 44 women ran for 12 weeks (Taub et al., Journal of Drugs in Dermatology, 2018). The regimen showed significant improvement versus placebo simultaneously in 5 major signs of skin aging, including superficial and deep wrinkles, visible pores, pigmentation and epidermal quality. See footnote 1 below.
Is there a subscription?
No. The Discovery Collection is a one-time purchase, and standard shipping within the U.S. is free.
Is it fragrance free?
Yes. The Discovery Collection is fragrance free.
What if I want to return it?
Your order is backed by our 45-day money-back guarantee. Call +1.888.368.5372 or email CustomerService@DefenAge.com to start a return. Standard shipping within the U.S. is free.
Your skin still knows how to renew. Give it the signal.
Two weeks of the complete regimen, backed by our 45-day money-back guarantee.
Discover Your New Skin1 Taub A, Bucay V, Keller G, et al. J Drugs Dermatol. 2018;17(4):426-441. Randomized, double-blind, placebo-controlled; n=44 women; 12 weeks; three-product regimen of 8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque. Significant improvement versus placebo simultaneously in 5 major signs of skin aging, including the appearance of superficial and deep wrinkles, visible pores, pigmentation and epidermal quality. NCT02765763.
2 2022 DefenAge Consumer Satisfaction Survey (June 2022), existing customers, all DefenAge products. 92% experienced results (789 of 858 who answered); 94% are satisfied with their results (814 of 862); 97% would purchase again (840 of 862).