Your First Two Weeks to Younger-Looking Skin
Try the complete, clinically studied regimen for two weeks, backed by our 45-day money-back guarantee.
Includes a full-size cleanser and our Signature Bag as a gift.
Free U.S. shipping. Fragrance-free. Made in the U.S.A.
Signature Bag included as our gift
A Simple Routine, Morning and Night
Three easy steps, plus a 2-minute masque once or twice a week.
1-Step Multi-Cleanse
CleanseStep 1 | AM & PM
24/7 Barrier Balance Cream
HydrateStep 2 | AM & PM
8-in-1 BioSerum
RenewStep 3 | AM & PM
2-Minute Reveal Masque
Reveal1–2 times a week
Why It Works
Your skin knows how to renew
Every time a small scratch heals, your skin relies on natural signals to renew. Defensins are part of that signal.
DefenAge brings the signal to your routine
Patented Age-Repair Defensins® in 8-in-1 BioSerum and 24/7 Barrier Balance Cream are bio-synthesized copies identical to two human defensins.
"The skin hasn’t lost its ability to renew. It’s lost the signal to start."Dr. Jessica Weiser, Dermatologist
Your skin shows the renewal
The result is visible improvement across multiple signs of aging, studied in a randomized, placebo-controlled clinical trial.1
Results You Can See
Unretouched photos. Drag the line to compare.
Why First-Time Customers Start Here
Try the complete regimen
All four steps, ready to use
See how your skin responds
Two weeks to feel the routine
Our Signature Bag, as a gift
Keeps your regimen together
45-day money-back guarantee
Love it, or return it hassle-free
Real Customers. Real Results.
★★★★★Verified Buyer
"After 8 weeks of using Defenage, my husband of 50 years and would not notice if my hair was purple, asked if I got BOTOX."
Stephanie M.
★★★★★Customer Review
"Got the trial size and FELL IN LOVE. Clinical power trio has been a game changer in two weeks I’m already getting asked what I’m doing differently!!"
Danielle
★★★★★Customer Review
"My dermatologist recommended as part of a brand new skin regimen for me. My husband (who doesn’t notice haircuts!) recognised the difference in my skin within a week! Miracle!"
Julie
★★★★★Verified Buyer
"I am a new user to this line, but have been very impressed with the results! Even my husband has asked what I am doing."
Cheryl C.
★★★★★Verified Buyer
"Last night I played tennis against someone I’ve not seen for awhile and she kept telling me how young I looked. I’m 67…"
Vickie M.
★★★★★Verified Buyer
"I’m only 2 weeks in to the regime, but I’m already noticing my pores are smaller and I’ve had 2 compliments on my skin from friends that don’t know I’ve started using something new, so… EXCITED!!!"
Kay S.
★★★★★Verified Buyer
"I have been using all of the Defenage product line for a few months now. I love it. I have had several girlfriends ask what I am using; the results are noticeable."
Betsy P.
★★★★★Verified Buyer
"After using 8 in 1 and Barrier cream, my husband tells me my skin looks great! Love that : ). I’m a 68 yo."
Jean S.
★★★★★Verified Buyer
"I faithfully use the masque, barrier balance cream, and BioSerum. My skin is much softer and brighter after only a few weeks of use. I am having many compliments on how my skin looks."
Pamela J.
Renew & Reveal Discovery Collection
Core age-repair regimen, two-week supply
Full-size 1-Step Multi-Cleanse
DefenAge Signature Bag, our gift
Free standard shipping within the U.S.
1 Taub AF, et al. J Drugs Dermatol. 2018. Randomized, double-blind, placebo-controlled; n=44 women; 12 weeks; three-product regimen of 8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque. Significant improvement versus placebo in the look of visible pores and superficial wrinkles. NCT02765763.
2 2022 DefenAge customer satisfaction survey, n=874 existing customers, all DefenAge products.