See What DefenAge Can Do for Your Skin
Try the complete, clinically studied regimen for two weeks, backed by our 45-day money-back guarantee.
Includes a full-size cleanser and our Signature Bag as a gift. Fragrance-free. Made in the U.S.A.
Signature Bag included as our gift
A Simple Routine, Morning and Night
Three easy steps, plus a 2-minute masque once or twice a week.
1-Step Multi-Cleanse
CleanseStep 1 | AM & PM
24/7 Barrier Balance Cream
HydrateStep 2 | AM & PM
8-in-1 BioSerum
RenewStep 3 | AM & PM
2-Minute Reveal Masque
Reveal1–2 times a week
Why It Works
"The skin hasn’t lost its ability to renew. It’s lost the signal to start."Dr. Jessica Weiser, Dermatologist
Your skin knows how to renew
Every time a small scratch heals, your skin relies on natural signals to renew. Defensins are part of that signal.
DefenAge brings the signal to your routine
Patented Age-Repair Defensins® in 8-in-1 BioSerum and 24/7 Barrier Balance Cream are bio-synthesized copies identical to two human defensins.
Your skin shows the renewal
The result is visible improvement across multiple signs of aging, studied in a randomized, placebo-controlled clinical trial.1
Results You Can See
Unretouched photos. Drag the line to compare.
Individual results vary.
Why First-Time Customers Start Here
Try the complete regimen
All four steps, ready to use
See how your skin responds
Two weeks to feel the routine
Our Signature Bag, as a gift
Keeps your regimen together
45-day money-back guarantee
Love it, or return it hassle-free
Real Customers. Real Results.
★★★★★Verified Buyer
"After 8 weeks of using Defenage, my husband of 50 years and would not notice if my hair was purple, asked if I got BOTOX."
Stephanie M.
★★★★★Customer Review
"Got the trial size and FELL IN LOVE. Clinical power trio has been a game changer in two weeks I’m already getting asked what I’m doing differently!!"
Danielle
★★★★★Customer Review
"My dermatologist recommended as part of a brand new skin regimen for me. My husband (who doesn’t notice haircuts!) recognised the difference in my skin within a week! Miracle!"
Julie
★★★★★Verified Buyer
"I am a new user to this line, but have been very impressed with the results! Even my husband has asked what I am doing."
Cheryl C.
★★★★★Verified Buyer
"Last night I played tennis against someone I’ve not seen for awhile and she kept telling me how young I looked. I’m 67…"
Vickie M.
★★★★★Verified Buyer
"I’m only 2 weeks in to the regime, but I’m already noticing my pores are smaller and I’ve had 2 compliments on my skin from friends that don’t know I’ve started using something new, so… EXCITED!!!"
Kay S.
★★★★★Verified Buyer
"I have been using all of the Defenage product line for a few months now. I love it. I have had several girlfriends ask what I am using; the results are noticeable."
Betsy P.
★★★★★Verified Buyer
"After using 8 in 1 and Barrier cream, my husband tells me my skin looks great! Love that : ). I’m a 68 yo."
Jean S.
★★★★★Verified Buyer
"I faithfully use the masque, barrier balance cream, and BioSerum. My skin is much softer and brighter after only a few weeks of use. I am having many compliments on how my skin looks."
Pamela J.
Individual results vary.
Renew & Reveal Discovery Collection
Core age-repair regimen, two-week supply
Full-size 1-Step Multi-Cleanse
DefenAge Signature Bag, our gift
Visible results build with consistent use.
1 Taub AF, et al. J Drugs Dermatol. 2018. Randomized, double-blind, placebo-controlled; n=44 women; 12 weeks; three-product regimen of 8-in-1 BioSerum, 24/7 Barrier Balance Cream and 2-Minute Reveal Masque. Significant improvement versus placebo in the look of visible pores and superficial wrinkles. NCT02765763.
2 2022 DefenAge customer satisfaction survey, n=874 existing customers, all DefenAge products.