7 Reasons It’s Called “Microneedling in a Bottle”
Eight serums in one feather-light formula, built on proprietary Age-Repair Defensins®.
Discover Your New Skin
- Free standard shipping on orders $60+
- 45-day money-back guarantee
- Clinically proven in 11 studies
- Made in the U.S.A.
- Proprietary Age-Repair Defensins®
- U.S. Patent No. 11,491,096
- 4.9 stars from 1,581 reviews
Seven reasons it has become DefenAge’s signature serum.
Studied in a 12-week double-blind clinical trial, recommended by leading dermatologists as a retinol alternative, and rated 4.9 stars from more than 1,500 reviews.
Tested in a double-blind clinical study.
In the published 12-week trial, women used the 8-in-1 BioSerum morning and night as part of DefenAge’s three-step regimen, and their results were measured against a placebo.
- 44 women aged 41 to 71
- 6 weeks of proven results
- Double-blind, placebo-controlled study across three U.S. clinics
- Peer-reviewed in the Journal of Drugs in Dermatology, 2018
Why it earned the name microneedling in a bottle.
In a clinic, microneedling signals the skin’s natural renewal through tiny, controlled needle passes.
Defensin molecules send skin that same renewal signal, which is why dermatologists call it ‘microneedling in a bottle.’
Proprietary Age-Repair Defensins® · U.S. Patent No. 11,491,096
Recommended by leading dermatologists as a retinol alternative.
“The biggest breakthrough in skincare since the discovery of retinoids.”
“DefenAge really represents a major advanced paradigm shift seen once per decade. The science is remarkable.”
“I believe that DefenAge is the next biggest game-changer in topical products for anti-aging.”
“DefenAge has been a game changer in my practice. If I am going to choose one product, I will choose DefenAge.”
54%More than half of DefenAge customers first heard about it from a physician.2022 satisfaction survey, 874 customers.
Discover Your New Skin · $198A 4.9-star rating from verified buyers.
“My skin looks and feels healthier than it has in years. That’s saying a lot for someone who is in her late sixties!”
“I’ve been using 8-in-1 Bioserum for years, and I’m so happy with the results. I used to have very visible sun damage on my neck and decollete, but this product has all-but-eliminated the redness and roughness.”
“The 8 in 1 serum is very effective. I have been getting compliments on my skin tone and condition since I started using the product 10 years ago. It was recommended by a dermatologist and from a plastic surgeon.”
It works with the skincare you already love.
Keep your cleanser, your moisturizer and the serums you like. Defensins don’t compete with other skincare. Apply the BioSerum last, because defensins help seal moisture into the skin and nothing needs to go on top except sunscreen and makeup.
- CleanseAny cleanser you like.
- Your usual skincareSerums, treatments, moisturizer, eye cream.
- 8-in-1 BioSerum, lastOne pump over the face and around the eyes, one over the neck. Morning and night.
- Morning only: sunscreen and makeupMany find makeup goes on smoother.
96% of consumers who use CHANEL skincare also like the results they see with DefenAge.Survey 2022, n=172, data on file.
“I was concerned that the recommended 1 pump was not enough but surprisingly it provides full coverage and goes on very silky smooth.”
45 days to see it on your own skin.
If it isn’t right for your skin, it qualifies for DefenAge’s money-back guarantee. The window covers the 6-week mark, when the published study took its 3D skin scans.
- Day 1Start morning and night, as the last step of your routine.
- Week 6The published study’s 3D skin scans
- Day 45Not right for your skin? Call or email us to start a return.
Customer service, for questions or a return: +1.888.368.5372 · CustomerService@DefenAge.com
Eight serums. One step.
- Antioxidant SerumFor brighter-looking skin
- Niacinamide SerumFor a more even-looking tone
- Hyaluronic Acid (HA) SerumLow-weight HA for lasting hydration
- Collagen SerumSupports the look of firmness
- Calming SerumA blend of soothing botanicals
- Peptide SerumSmooths the look of wrinkles
- DNA-Repair Enzyme SerumA botanical enzyme complex
- Retinol-Alternative SerumAlpha-defensin 5 and beta-defensin 3
$3.54a day. The MEGA bottle lasts about 8 weeks.
“Fantastic product. This has replaced the multiple other products that I was using previously. My skin is smooth and moisturized after using this.”
8-in-1 BioSerum
1.5 fl oz | 45ml | MEGA Size · Fragrance Free
DefenAge’s iconic Best Seller: eight serums in one step, built on proprietary Age-Repair Defensins®.
Sorry, that didn’t go through. Taking you to the 8-in-1 BioSerum page to finish there.
Free shipping on $60+ · 45-day money-back guarantee · Made in the U.S.A.
Free standard shipping within the continental U.S. Quality guaranteed only when sold by defenage.com or authorized professionals.
As featured in
- 2026 Best of the YearAwarded to the 8-in-1 BioSerum
- Skincare Anarchy 2026 Top Picks Beauty AwardsSkincare: Serums
- People en Español Star Product Hall of FameInducted into the first Hall of Fame, 2025
Before you decide.
Why does it cost $198?
You are buying eight serums in one bottle: antioxidant, niacinamide, hyaluronic acid, collagen, calming, peptide, DNA-repair enzyme and retinol-alternative, built around DefenAge’s proprietary Age-Repair Defensins® and tested in 11 clinical studies. The MEGA bottle lasts about 8 weeks of mornings and nights, which works out to about $3.54 a day. And you have 45 days to decide it is worth it.
Where does it go in my routine?
Last. Cleanse, apply your other serums and creams, then one pump of the BioSerum over the face and around the eyes and one over the neck. In the morning, only sunscreen and makeup go on top; at night, nothing does. Defensins help seal moisture into the skin, so anything applied after them absorbs less.
Can I keep using my other skincare?
Yes. Defensins don’t conflict or compete with other skincare, whatever brand you use. It also works alongside retinol or bakuchiol serums, and it already contains a blend of antioxidants, so a separate vitamin C serum is optional.
Does it contain retinol?
No. Dermatologists recommend it as a retinol alternative: its Alpha-Defensin 5 works on the skin’s own renewal pathway without retinol’s irritation, so it suits sensitive skin.
Is it right for sensitive or acne-prone skin?
It is suitable for all skin types, including sensitive and acne-prone skin, and it returned an outstanding safety profile in its studies. Stick to the recommended amount: one pump for the face and one for the neck.
Can I use it around my eyes?
Yes. It is ophthalmologist and dermatologist tested, safe around the eyes and for contact lens wearers. Keep it out of the eyes themselves.
When will I see results?
Visible results typically show within a few weeks of use morning and night. More pumps won’t speed it up: the formula is balanced for one pump on the face and one on the neck, used every day.
Can I use it with microneedling or laser treatments?
Yes, dermatologists call it a treatment multiplier. After microneedling, RF-microneedling or fractional laser, start 24 to 48 hours after the procedure; after ablative laser, start 7 days after. Apply twice a day for 2 to 4 weeks, and follow your provider’s aftercare.
How does shipping and the guarantee work?
Standard shipping is free on orders of $60 and up within the continental U.S. The 8-in-1 BioSerum qualifies for DefenAge’s 45-day money-back guarantee. Questions: +1.888.368.5372 or CustomerService@DefenAge.com.
Your skin still knows how to renew. Give it the signal.
Eight serums in one step, morning and night.
Discover Your New Skin · $198