27% SAVINGS compared to purchase individually

Earn 438 points in DefenAge® Skin Club with this purchase.


27% SAVINGS compared to purchase individually

Earn 438 points in DefenAge® Skin Club with this purchase.

/ $438.00 with free account /

Consistency is key, especially in your day and night skincare routine. By incorporating targeted products into your routine, you can nourish and protect your skin during the day and promote rejuvenation while you sleep.

Before the day, a DefenAge skincare routine in the morning offers essential protection and hydration. The 3D Eye Radiance Cream and 1-Step Multi-Cleanse help revitalize the delicate eye area and cleanse your skin, while the Barrier Balance Cream provides a shield against environmental stressors. Much like microneedling, Defensin-molecules help to activate dormant new skin cells within the body to address the appearance of fine lines. Our 8-in-1 BioSerum has the highest concentration of Age-Repair Defensins with a light-weight application making it perfect to incorporate as the last step of your daily regimen.

By consistently following a night skincare routine with DefenAge, you can awaken to visibly improved skin that looks and feels renewed. DefenAge's nighttime routine offers a range of powerful products designed to maximize your skin's rejuvenation potential. The 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 6-Week Perfection Neck Cream are key players in this routine, working synergistically to optimize cellular renewal, reduce the appearance of crepey skin, fine lines, and wrinkles, and restore moisture levels.


  • STEP 1: 1-Step Multi-Cleanse, 5.0 oz.
  • STEP 2 | FACE: 24/7 Barrier Balance Cream, 1.5 fl. oz.
  • STEP 2 | EYES: 3D Eye Radiance Cream, 0.5 fl. oz.
  • STEP 2 | NECK: 6 Week Perfection Neck Cream, 1.5 fl. oz.
  • STEP 3: 8-in-1 BioSerum, 1.5 fl. oz.
  • SWEET DREAMS STEP: 100% Silk Pillowcase, King Size | 20 in x 36 in

Having a daily skincare routine is important because it allows you to establish healthy habits and address specific skincare concerns, like crepey skin. Regularly cleansing, nourishing, and protecting your skin can help prevent damage, improve skin texture, and promote a more youthful appearance over time.

DefenAge's innovative products work together to promote cell renewal, diminish the signs of aging, and restore moisture. Perfect skincare for combination, dry , or oily skin. Embrace the power of nighttime skincare and give your skin the care it deserves, unlocking the secret to age-repair beauty.

All cosmetic products are made in the U.S.A.



1-Step Multi-Cleanse

STEP ONE | 1-Step Multi-Cleanse

Daily: AM, PM

Place dime-sized portion of cleansing gel onto fingertips. Gently massage over dry skin for 15 seconds. Moisten fingertips and massage using circular motions. Repeat until white cleansing milk develops. Rinse well with warm water. If desired, use a clean facecloth or cleansing sponge to remove excess cleanser. Pat dry with clean towel. Follow with STEP TWO (24/7 Barrier Balance Cream, 3D Eye Radiance Cream, and 6-Week Perfection Neck Cream).
Suitable for all skin types.



24/7 Barrier Balance Cream

STEP TWO - FACE | 24/7 Barrier Balance Cream

Daily: AM, PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.



3D Eye Radiance Cream

STEP TWO - EYES | 3D Eye Radiance Cream

Daily: AM, PM

After cleansing, while the skin is still moist from rinsing, pump a drop of radiant under-eye treatment onto the applicator. Lightly dab three dots of dark circle eye cream below each eye. If not applying eye makeup, continue to apply to the upper eyelid, but avoid contact with eyes and eye lashes. Using the applicator, massage cream around the eyes.
Suitable for all skin types.



6-Week Perfection Neck Cream

STEP TWO - NECK | 6-Week Perfection Neck Cream

Daily: PM

Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.



8-in-1 BioSerum

STEP THREE | 8-in-1 BioSerum

Daily: AM, PM

Apply after the 24/7 Barrier Balance Cream,
and 6-Week Perfection Neck Cream.

30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. 
Suitable for all skin types.

DefenAge is proven in more than 20 clinical studies. All DefenAge formulas are dermatologist tested. 1-Step Multi-Cleanse, 3D Eye Radinace Cream, and 8-in-1 BioSerum are also ophthalmologist tested.

Multi-center placebo-controlled double-blind clinical study shows that DefenAge “globally improves the visual appearance of aging skin” and “offers most of the advantages of time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin.”
Journal of Drugs in Dermatology 2018, 17(4): p. 426-441Amy Taub MD, Vivian Bucay MD, Gregory Keller MD, Jay Williams PhD, and Darius Mehregan MD

Learn More




Age-Repair Defensins® | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

Hyaluronic Acid

Liposome Encapsulated (Face Cream) | Low Molecular Weight (Serum)

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Ophiopogon Japonicus Root Extract and

Sinorhizobium Meliloti Ferment

skin's barrier balance • natural hydration

The powerful blend of natural extracts balances the skin’s barrier, saves the skin’s natural moisture, and promotes the levels of Natural Moisturization Factors (NMFs).



moisturiozation • antioxidant 

Energizes skin hydration. Prevents moisture loss while restoring visible skin’s suppleness and flexibility. Fights skin damage and free radicals.




soothing • protection

Helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. Hydrates the skin from within. Proven humectant.



Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


This set contains seven of DefenAge’s top products; all of them are formulated based on the enhanced clean beauty standards. Find more information about our standards and why we raised the bar for skincare safety requirements on our Clean Beauty page.


The bottles, tubes, and boxes are fully recyclable, please recycle.

Not tested on animals.


The detailed ingredient lists can be reviewed on the individual product pages:


1-Step Multi-Cleanse

24/7 Barrier Balance Cream

3D Eye Radinace Cream

6-Week Perfection Neck Cream

8-in-1 BioSerum



For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.



Quality guaranteed ONLY when sold by or authorized professionals, otherwise it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 



This product is qualified for the Money Back Guarantee.

In case of a refund, all products in this bundle should be returned.
Return Policy


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