1 bottle

This product is covered by U.S. Patent No. 11,260,013.



1 bottle

This product is covered by U.S. Patent No. 11,260,013.

BeautyMatter NEXT Awards 2023 Best Hair Serum AwardBEST

This pack contains 3 bottles of the 150K Hair Follicle Serum, 0.33 fl. oz. each. 1-month supply if used as recommended.

150K Hair Follicle Serum Details

Getting to the Root of Healthy Hair and Beard.

The human scalp contains up to 150,000 hair follicles. The 150K Hair Follicle Serum takes care of all of them. No Follicles Left Behind!

The 150K Hair Follicle Serum – Men’s Edition is a rejuvenation-inspired, super-charged scalp and beard serum.

Results You Notice

  • •  90% fewer signs of hair shedding.
  • •  67% fuller hair.
  • •  First results in 30 days or sooner.

* Clinical study of men and women, ages 39-71. Individual results may vary.

How Our Scalp Serum Works

The DefenAge 150K Hair Follicle Serum works by revitalizing the environment surrounding the hair follicles, creating an optimal ecosystem to help the follicles work their best. It also:

  • •  Promotes sustainable health and wellness of the scalp and skin under the hair and beard.
  • •  Revives follicle nutrition support, nourishes blood irrigation.
  • •  Revives the natural moisture of the scalp, skin under the hair and beard, as well as hair roots.
  • •  Promotes the scalp and skin’s barrier and immunity, optimizes the delicate ecology of the scalp and the skin under the hair and beard.
  • •  Rejuvenates the smoothness of the scalp and the skin under the hair and beard.
  • •  Minimizes the look of pigmentation and discolorations of the skin under the hair and beard.
  • •  Helps improve the appearance of inflammation and itchiness of the scalp and skin under the beard.
  • •  Addresses the appearance of grey hair on the head and brows, and visibly softens the hair color at the roots.
  • •  Helps reduce signs of shedding and hair falling out on the head.
  • •  Renews the look of hair volume, quality, and texture. Improves overall visible hair health.

Read a dermatologist’s opinion and recommendations ►

Why 150K Hair Follicle Serum Is Different

Our scalp and beard serum is an excellent cosmeceutical care for the scalp and the skin under the hair and beard. We’ve paired an advanced and targeted treatment with established and validated science to bring you a product that is unlike any other on the market. Here’s what makes the 150K Hair Follicle Serum different.

  • •  Based on the natural rejuvenation power of our body.
  • •  Evolved from proven science and is patent-protected.
  • •  Contains the BioSerum-level of Defensin-molecules, DefenAge’s iconic all-time best seller.
  • •  Contains 48 proven natural ingredients, shown clinical efficacy on scalp and hair. All ingredients are infused at their clinical performance concentration.
  • •  Free from drugs and hormones.
  • •  Can be combined with Rogaine, minoxidil or any other treatments if desired.
  • •  Lightweight, water-based formula with minimal addition of stabilizing ingredients.
  • •  Supplied in an innovated ampule that protects the serum’s integrity. The applicator allows convenient “no product wasted”-dosing directly to the hair roots, right to the hair follicles.
  • •  Non-irritating and gentle on sensitive scalp and skin.
  • •  Studied in an independent, third-party clinic.
  • •  Awarded as "BEST HAIR GROWTH SERUM" by NewBeauty Magazine.

Made in the U.S.A.

Press Releases

DefenAge® Skincare's 150K Hair Follicle Serum Takes Home BeautyMatter NEXT Award

“We’re honored to be recognized by BeautyMatter for our innovation in the hair care industry,” said Ray Wood, co-founder of DefenAge. "Going up against hair care giants with massive retail distribution was no easy feat, but just proves the extreme efficacy of our product.” Read more ►

DefenAge® 150K Hair Follicle Serum Won the “Best Hair Growth Serum” Award Presented by NewBeauty Magazine

The serum is proven to increase visible hair coverage and reduce hair shedding and is recommended for men with hair loss. Read more ►

DefenAge® Skincare Announces 150K Hair Follicle Serum

Patented technology with Age-Repair Defensins optimizes the scalp and skin under the hair for overall hair health. Read more ►

How to Use The 150K Hair Follicle Serum

150K Hair Follicle Serum Directions

Designed to recharge the scalp and the skin under the beard, keeping them fresh and healthy. Provides an optimal environment to help hair follicles perform their best. Please follow the directions below for optimal results.


Shake the bottle well before the first use, keeping the lid closed.

Step 1


A. Following the arrow on the button, turn the button counterclockwise to unlock.

B. Unscrew lid.

Step 2


Twice daily, in the morning and evening, apply the serum across a moist or dry scalp (2-3 pumps), or skin under the beard (2-3 pumps). Working in sections, press the tip of the applicator directly onto the scalp/skin and push the button to release the serum.

Step 3


Using fingertips, gently massage the serum into the hair roots, concentrating on areas of concern. Do not wash-out (leave product on); the evening application product should be left overnight.


Apply serum to problem areas, including areas with poor hair growth (scalp/beard), damaged skin under the beard, bald patches (scalp), areas with grey hair (scalp), and along the hair part (scalp).

Clinical Studies of the 150K Hair Follicle Serum

The 150K Hair Follicle Serum is clinically-tested by a Board-Certified dermatologist and shows an outstanding safety profile (hypoallergenic, non-sensitizing, non-irritating formula).

The efficacy clinical studies show that the defensin-containing serum, applied twice daily, caused progressive normalization of visible hair-growth metrics and hair qualities both on the head and beard, visible reduction of shedding, and normalization of scalp conditions including 90% fewer signs of hair shedding and up to 67% fuller hair (clinical studies of men and women, ages 39-71; individual results may vary).

Improvement in Scalp Quality and Visible Hair Coverage

Scalp | Scalp at 1 month - Before and After

Clinical photos are obtained from the study performed by an independent, third-party clinic. Photos have not been retouched.

Visible Hair Shedding Reduction

Scalp | Shedding Before and After

Clinical data is obtained from the study performed by an independent, third-party clinic.

Increase in Visible Hair Volume

Scalp | Visible Hair Volume - Before and After

Clinical data is obtained from the study performed by an independent, third-party clinic.

Increase in Visible Hair Presence

VISIBLE HAIR GROWTH SPEED TEST: One week after completely shaving with razor:

Scalp | Shaving Test - Before and After

Clinical photos are obtained from the pilot clinical study performed by an independent, third-party clinic. Photos have not been retouched.

Increase in Visible Beard Density

VISIBLE BEARD GROWTH SPEED TEST: One week after completely shaving with razor:

Beard | Before and After

Clinical photos are obtained from the pilot clinical study performed by an independent, third-party clinic. Photos have not been retouched.

150K Hair Follicle Serum Ingredients

Key Performance Ingredients and Technologies

Age-Repair Defensins® PRO | 5X | DefenAge's Exclusive

• Revitalize Environment Surrounding Follicles •

Defensins are natural molecules. They signal our body to create new and “fresh” cells by activating the body’s dormant reserves. They are also known as promoters of capillaries and activate nutrition supply. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.

Organic Pea Sprout Extract

• Rejuvenates Hair Life-Cycle •

Targets and optimizes the core of hair health. Boosts visible hair thickness.

Azalea-Isolated Yeast Extract

• Regenerates Visible Hair Density •

Optimizes the energy of the follicle cells, balances surrounding signaling molecules, and activates cell “memory.” The unique yeast strain, Pichia minuta, is rich in peptides, and isolated from flowers of azalea; it is converted into powerful cosmeceutical activity using advanced biotech-born technology.

Microalgae Extract

• Boosts Visible Hair Strength and Volume •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Vitamin B Complex | Niacinamide & Biotin

• Hydration • Circulation • Keratin •

Niacinamide (vitamin B3) and biotin (vitamin B7) are vital components of the hair-supporting system. The vitamins in this complex repair the natural moisturization of the scalp and cells surrounding the follicles, revive follicle oxygen supply, activate in-hair keratin, and enhance the appearance and feel of hair. Each vitamin B3 and B7, are present in two different forms in this formula to guarantee maximum benefits.

Antioxidant Complex

• Visible Hair Re-pigmentation • Oxidative Stress Relief •

The advanced detoxifying complex concentrate helps suppress free radicals and educates follicles to recover original natural color. The components of the complex are shown to reduce visible density of grey hair on the scalp and visibly soften hair color at the roots. The complex contains the bio-mimic to the naturally present in the body peptide, palmitoyl dipeptide-52, two phyto-extracts from the root of Spiny restharrow and black oat seeds, and vitamin E.

Fine Blend of Soothing and Calming Ingredients

• Scalp Calming and Soothing •

This formula is infused with a powerful and concentrated composi­tion of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.

Complex of Natural Boosting Ingredients and Technologies

• Overall Scalp and Follicle Health • Follicle Irrigation • Scalp Microbiome •

Our “know-how”-protected, advanced and powerful collection of proven scalp- and hair-supporting and revitalizing ingredients, includes natural flavonoid Apigenin, extracts from turmeric, celery seeds, apples and sugar cane, and water-friendly form of castor oil. This complex provides purity and comfort for scalp, supports healthy scalp microbiome and nourishes its delicate ecology, and promotes your own defensins.


The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excused from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.


The box is fully recyclable, please recycle. We do not test products on animals.


Water (Aqua), Pentylene Glycol, Butylene Glycol, Niacinamide, Dimethyl Isosorbide, Caprylic/Capric Triglyceride, Octyldodecanol, Glycerin, Alpha-Defensin 5, Beta-Defensin 3, Hexapeptide-11, Palmitoyl Dipeptide-52, Biotinoyl Tripeptide-1, Biotin, Curcuma Longa (Turmeric) Rhizome Extract, Pisum Sativum (Pea) Sprout Extract, Apium Graveolens (Celery) Seed Extract, Cardiospermum Halicacabum Flower / Leaf / Vine Extract, Camellia Sinensis Leaf Extract, Rosemarinus Officinalis (Rosemary) Leaf Extract, Isochrysis Galbana Extract, Avena Strigosa Seed Extract, Pyrus Malus (Apple) Fruit Exract, Citrus Limon (Lemon) Fruit Extract, Saccharum Offinarum (Sugar Cane) Extract, Ononis Spinosa Root Extract, Yeast Extract, Ribes Nigrum (Black Current) Seed Oil, Helianthus Annus (Sunflower) Seed Oil Unsaponifiables, Helianthus Annuus (Sunflower) Seed Oil, Leuconostoc / Radish Root Ferment Filtrate, Betaine, Tocopherol, Tocopheryl Nicotinate, Tocopheryl Acetate, Ubiquinone, Apigenin, Oleanolic Acid, Glycogen, Epigallocatechin Gallatyl Glucoside, Sodium Stearoyl Glutamate, Methyl Glucose Sesquistearate, Ammonium Acryloyldimethyltaurate / VP Copolymer, Phospholipids, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, I-Alanyl-I-Glutamine, Maltodextrin, Gellan Gum, Sodium Phytate, Albumin, Phytic Acid, Potassium Sorbate, Hexylene Glycol, Phenoxyethanol, Sodium Benzoate, Sodium Chloride.
Fragrance free.

150K Hair Follicle Serum Guarantees


The quality of the 150K Hair Follicle Serum is guaranteed ONLY when sold by defenage.com or authorized professionals; otherwise, it may be counterfeit, black market, old, or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay, or other unauthorized sources. 


This 150K Hair Follicle Serum product qualifies for the Money-Back Guarantee.
Return Policy ►

What's the difference between men & women editions of the 150K Hair Follicle Serum?
There is no difference in formulation between the Men's and Women's Editions. The only difference is that the Men's Edition includes more detailed instructions on how to apply the hair serum to a beard/facial hair.
Can this serum be used on the eyebrows?
Yes, the 150K Hair Follicle Serum is safe to use on the eyebrows. Although our initial pilot study did not study the product's performance on eyebrows, many of our customers have reported excellent results for the improvement of overplucked or diminishing eyebrows.
Can this serum be used with other hair loss products including supplements, Minoxidil/Rogaine, topical steroids, etc?
Yes, this serum can be used in combination with almost all other products and will only enhance your results. If using a topical product, we recommend to apply the other product first, then layer the 150K Hair Follicle Serum over those targeted areas.
Is this serum safe to use on color-treated hair?
The 150k Hair Follicle Serum is water-based and does not strip color-treated hair. Over time of use, you may notice that your roots may be less grey. The antioxidant complex in this serum relieves oxidative stress and could therefore restore your original hair color.
Can this serum be used to treat common scalp conditions like dandruff?
Yes, this serum contains defensins which will create new skin resulting in improved overall health scalp health and provide an environment for your hair follicles to work their best. Customers with stubborn scalp issues have experienced much improvement when using the 150K Hair Follicle Serum.
What causes hair loss?
Hair loss is a common and complicated condition that can be attributed to various reasons. Most hair loss experts say that it usually comes down to genetics. It is best to consult with a medical professional to determine the root cause of hair loss and treatments to prevent and address hair loss. DefenAge's 150K Hair Follicle Serum provides an easy-to-use and effective option to help your hair follicles work their best. We've taken the proven science of defensins and applied it to scalp health. Not only are our customers experiencing improvement in visible hair density, but are also noticing less hair shedding, thicker strands of hair, and even repigmentation of hair back to it's original youthful color.