CLINICAL POWER TRIO + | Pack of 3 | 2022

Pack of 3 (Clinical Power Trio+)

Holiday PROMO ❄
Shop Gifts At DefenAge!

VALUE Pack of 3:
Third Clinical Power Trio+ in your shopping bag is FREE!

Holiday Promo


Limited time offer, until December 31st only or until supplies last.

A portion of the proceeds from DefenAge’s holiday sales will go towards a donation to the Monarch School of San Diego.

You can earn 636 points in DefenAge® Skin Club with this purchase.

CLINICAL POWER TRIO + | Pack of 3 | 2022

Pack of 3 (Clinical Power Trio+)

Holiday PROMO ❄
Shop Gifts At DefenAge!

VALUE Pack of 3:
Third Clinical Power Trio+ in your shopping bag is FREE!

Holiday Promo


Limited time offer, until December 31st only or until supplies last.

A portion of the proceeds from DefenAge’s holiday sales will go towards a donation to the Monarch School of San Diego.

You can earn 636 points in DefenAge® Skin Club with this purchase.


Pay as low as $55/mo with Affirm. Use Amazon Pay at Checkout.

Innovator Award Innovator Award Affirm Pay

Price above is shown for the bundle of 3 kits (VALUE Pack of 3). Each kit in this bundle contains a 6 - 8 week supply of product (Full+ Size).

Clinical Power Trio+ is a PLUS-edition of our best-selling Clinical Power Trio; we upgraded it with the MEGA size 8-in-1 BioSerum.


CLINICAL POWER TRIO is DefenAge's signature, clinical-study tested, dermatologist recommended skin care treatment. We recommend starting DefenAge with the Clinical Power Trio:

  • •  Corrects visible signs of skin exhaustion, damage and aging on a global scale.
  • •  Defensin-loaded, DefenAge's core skin care regimen.
  • •  Efficacy proven based on comprehensive clinical studies.
  • •  Initial results appear in the first week of use. Full range of results - in 6 weeks.


This skin care is winner of the Aesthetic Award 2018, presented by Dermatology Times and The Aesthetic Channel, and is voted as the Nonsurgical Innovator of the year for The Aesthetic Awards 2019.


Clinical Power Trio+ contains Full/MEGA sizes of:

  • 8-in-1 BioSerum | MEGA Size | 1.5 fl. oz.
  • 24/7 Barrier Balance Cream | 1.5 fl. oz.
  • 2-Minute Reveal Masque | Net Wt. 2.5 oz.


Made in the U.S.A.


If you are uncertain if DefenAge is good for you, please consider trying the 24-Hour Fast Starter Kit, which contains a trial version, 2-3 day supply, of the Clinical Power Trio. You might be surprised how much your skin can achieve after just a few days of experience with these three products together. 



Dermatologist And Aesthetic Professionals’ Recommendations:

"DefenAge has been a game changer in my practice. My patients see improved visible pigmentation, decreased number of pores and fine lines, and an overall glow to their skin. I see the best results in patients showing age related skin conditions with fine lines, enlarged pores, loss of texture and overall dullness of the skin. It is the only product I personally use on a regular basis,"

Dermatologist Steven Swengel, MD, Los Gatos, CA


"We completed a multicenter clinical trial which was double-blinded and placebo controlled that showed a statistically significant improvement in fine and coarse wrinkles, melanin, and pores. This sounds almost too good to be true with no evidence of irritation and some good safety markers, yet it was a rigorous study. We recommend the DefenAge system for almost any patient since it reduces oiliness and the appearance of pores but does not cause dryness or irritation. I especially love it for skincare newbies, as it is easy to give them the kit and add a sunscreen. For most sophisticated skin care users, I may recommend the 8-in-1 BioSerum as a replacement for growth factor products or in addition to them. Clinically, patients love it and see a difference very quickly, which really helps with compliance,"

– Dermatologist Amy Forman Taub, MD, Chicago IL


"DefenAge addresses many signs of skin aging on a global scale. With DefenAge, skin can naturally turn back the clock,"

– Dermatologist Natalie Curcio, MD, Nashville, TN


"Patients aged 18 to 90, male and female, have tried the product, and are on their second and third cycles of buying it. The results are consistent. Improvement in tone and quality of skin, blemish reduction, and softening of static lines and rhytids,"

– Plastic surgeon Gregory Chernoff, Indianapolis, IN


"DefenAge skincare has given us a remarkable tool to improve the appearance of skin. In our experience, sustainable results are seen quickly. My initial experience was treating only my left forearm, keeping my right arm as a control. Within 5 days, a noticeable difference in the texture and color of my arms could be seen. I continued to use the product on my arm for 6 weeks, the results of that treatment are still apparent years later. Showing the effects of DefenAge on my arm has been an impressive way to demonstrate the efficacy of the product line. DefenAge is one of our most requested brands,'

- Janice Pastorek, BSN, RN, New York City




Opinions and Stories


Top 10 Dermatologist Recommended Skincare Commandments

by Veronica Webb, supermodel mom and influencer

Want to know how 56-year-old supermodel Veronica Webb’s anti-aging clean beauty secrets? 90’s cover girl and runway star spills the tea on her top 10 ten skincare commandments. Get the scoop on science-backed clean beauty skincare advice from the world’s best dermatologists from Paris to Park Ave. Read more ...


The Secret to Smaller Pores

by Nicole Pearl Kaplan, beauty editor and lifestyle expert

One of the keys to younger looking skin is having tiny pores. One expert reveals a few tricks you can implement to shrink your pore size. This starts with following a specific skincare routine that includes a detoxifying face mask and choosing the right sheets to aide your skin while you sleep. Read more ...


When Dermatologists Talk, I Listen

by Cheryl Kramer Kaye, beauty & fashion writer

Where do you go for your skin-care product advice? Many of us scan our Instagram feeds, read user reviews, or take suggestions from facialists. But according to one beauty pro, you should look to a dermatologist to help guide your decisions. Here’s why. Read more ...


Take Luxurious Care of Your Skin at Home with Premium Products From DefenAge

If you want to upgrade your skin care routine and embrace naturally radiant-looking skin, look at products from DefenAge. From cleansing and moisturizing to exfoliating and reducing the appearance of fine lines, you’ll be treated to innovative and effective products. With Age-Repair Defensins in DefenAge’s effective skin care formulas, you can encourage brand-new, healthy skin cells. Suitable for all skin types, DefenAge products are advanced anti aging skin care. Read more ...


Tips for Preventing Skin Problems From Constant Mask Wearing

Dry, winter skin and constant face mask coverage can irritate your skin, as you may have experienced. You’ll want to treat your skin gently and with clean ingredients and formulas. Dermatologist recommended skin care is a good place to start. Keeping up with your daily skin care routine is important, too, so that your skin is clean, hydrated, and protected. Get some more tips here. Read more ...


Discover Powerful Dermatologist Recommended Skin Care Products From DefenAge

When you want a skin care regimen that helps diminish visible signs of aging and supports smoother-looking skin, try DefenAge’s signature Clinical Power Trio. The trio of dermatologist recommended skin care products includes 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 2-Minute Reveal Masque. Their formulas feature DefenAge’s proprietary Age-Repair Defensins technology, which can be an alternative to strong retinol creams. All of the DefenAge products are rigorously tested for efficacy and safety so that you can promote lasting results with your very own Clinical Power Trio.



24/7 Barrier Balance Cream

STEP TWO | 24/7 Barrier Balance Cream

Daily: AM | PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.



8-in-1 BioSerum

STEP THREE | 8-in-1 BioSerum

Daily: AM | PM

Apply after 24/7 Barrier Balance Cream.

30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.



2-Minute Reveal Masque

1-2 Xs A WEEK | 2-Minute Reveal Masque

Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream).
Not recommended for acne, extremely sensitive or abraded skin.




For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


We are rigorously testing all our products for efficacy and safety. The Clinical Power Trio, its individual products and our signature ingredient Age-Repair Defensins, has been tested in 11 clinical studies by today. All products have been tested by Board Certified Dermatologists, and the 8-in-1 BioSerum, which is recommended to be applied on the areas around the eyes, was also tested by a Board Certified Ophthalmologist. All clinical studies returned outstanding safety and efficacy profiles; the data is published in peer-review clinical journals and presented on dermatologist and aesthetic medical conferences.


The largest multi-center, placebo-controlled clinical study, which tested the Clinical Power Trio, underwent a review of independent Institutional Review Board and is published in the Journal of Drugs in Dermatology. The full text of the article and study results are available on the journal’s website. Based on the results of this study, dermatologists recommend defensins as an safe and efficient alternative to the cosmetic retinol. The study also proved the performance of Clinical Power Trio as an universal anti-aging skin care that addresses visible signs of skin aging on a global scale. Please visit Our Story page for before and after images and details about the multi-center study.



  1. Taub A, Bucay V, Keller G, Williams J, Mehregan D. Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation. J Drugs Dermatol. 2018 Apr 1;17(4):426-441. PMID: 29601620.
  2. Duncan DI. Microneedling with Biologicals: Advantages and Limitations. Facial Plast Surg Clin North Am. 2018 Nov;26(4):447-454. PMID: 30213426.
  3. Taub AF, Pham K. Stem Cells in Dermatology and Anti-aging Care of the Skin. Facial Plast Surg Clin North Am. 2018 Nov;26(4):425-437. PMID: 30213424.
  4. Keller G. Topically Applied Defensins for Comprehensive Improvement of Aging Skin. The American Academy of Facial Plastic and Reconstructive Surgery/COSM – Book of Abstarcts. 2016 A021.
  5. Multi-Center, Double-Blind Clinical Study Validates DefenAge® As A Best-In-Class Anti-Aging Solution, Naturally Turning Back The Clock. Business Wire. 2018 Apr 03. Press Release.
  6.  The Aesthetic Awards Introduces Peer Voting At Ninth Annual Ceremony. 2019 Sep 17. The Aesthetic Guide.
  7.  The Aesthetic Show Annual Awards Ceremony Honors Aesthetic Innovators And Influencers. 2018 Sep 19. The Aesthetic Guide.

Learn More ►

Dermatologist Recommended Skin Care | Core Regimen



Age-Repair Defensins® | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

Hyaluronic Acid

Liposome Encapsulated (Cream) | Low Molecular Weight (Serum)

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


We have carefully formulated our products to exclude multiple harmful and questionable ingredients. In addition to DefenAge’s standard list of the excluded ingredients, products in this kit do not contain fragrance. DefenAge’s standard list of the excluded ingredients is shown on our Clean Beauty page.


The tubes and box are fully recyclable, please recycle.

Not tested on animals.


The detailed ingredient lists are shown on the individual product pages:


24/7 Barrier Balance Cream | No Fragrance Added ►

8-in-1 BioSerum | No Fragrance Added ►



Quality guaranteed ONLY when sold by or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



This product is qualified for the Money Back Guarantee.
Return Policy ►


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