This product is covered by U.S. Patents No. 11,491,096 and 11,020,452.


This product is covered by U.S. Patents No. 11,491,096 and 11,020,452.

/ $285.00 with free account /

Innovator Award Innovator Award

Six Weeks to a Youthful Transformation: Global Anti-Aging Excellence

Imagine the opportunity to have skin that on average appears 18 years younger...and in only 6 weeks!  With DefenAge's Clinical Power Trio, this vision transforms into reality. Partnering with a fashion and beauty expert, Olga Ferrara @olgaferrara_ny, we're thrilled to extend an exclusive invitation.

CLINICAL POWER TRIO is DefenAge's signature, clinical-study tested, dermatologist recommended skin care treatment. We recommend starting DefenAge with the Clinical Power Trio:

  • •  Corrects visible signs of skin exhaustion, damage and aging on a global scale.
  • •  Defensin-loaded, DefenAge's core skin care regimen.
  • •  Efficacy proven based on comprehensive clinical studies.
  • •  Customers found visible improvements in fine lines, wrinkles, hyperpigmentation, pore size, and crepey skin.
  • •  Initial results appear in the first week of use. Full range of results - in 6 weeks.


This skin care is winner of the Aesthetic Award 2018, presented by Dermatology Times and The Aesthetic Channel, and is voted as the Nonsurgical Innovator of the year for The Aesthetic Awards 2019.


Clinical Power Trio contains full sizes of:

  • 8-in-1 BioSerum, Concept Anti-Aging Cream, 1 fl. oz.
  • 24/7 Barrier Balance Cream, 1.5 fl. oz.
  • 2-Minute Reveal Masque, Net Wt. 2.5 oz.


Made in the U.S.A.


If you are uncertain if DefenAge is good for you, please consider trying the 24-Hour Fast Starter Kit, which contains a trial version, 2-3 day supply, of the Clinical Power Trio. You might be surprised how much your skin can achieve after just a few days of experience with these three products together. 



Dermatologist And Aesthetic Professionals’ Recommendations:

"DefenAge has been a game changer in my practice. My patients see improved visible pigmentation, decreased number of pores and fine lines, and an overall glow to their skin. I see the best results in patients showing age related skin conditions with fine lines, enlarged pores, loss of texture and overall dullness of the skin. It is the only product I personally use on a regular basis,"

Dermatologist Steven Swengel, MD, Los Gatos, CA


"We completed a multicenter clinical trial which was double-blinded and placebo controlled that showed a statistically significant improvement in fine and coarse wrinkles, melanin, and pores. This sounds almost too good to be true with no evidence of irritation and some good safety markers, yet it was a rigorous study. We recommend the DefenAge system for almost any patient since it reduces oiliness and the appearance of pores but does not cause dryness or irritation. I especially love it for skincare newbies, as it is easy to give them the kit and add a sunscreen. For most sophisticated skin care users, I may recommend the 8-in-1 BioSerum as a replacement for growth factor products or in addition to them. Clinically, patients love it and see a difference very quickly, which really helps with compliance,"

– Dermatologist Amy Forman Taub, MD, Chicago IL


"DefenAge addresses many signs of skin aging on a global scale. With DefenAge, skin can naturally turn back the clock,"

– Dermatologist Natalie Curcio, MD, Nashville, TN


"Patients aged 18 to 90, male and female, have tried the product, and are on their second and third cycles of buying it. The results are consistent. Improvement in tone and quality of skin, blemish reduction, and softening of static lines and rhytids,"

– Plastic surgeon Gregory Chernoff, Indianapolis, IN


"DefenAge skincare has given us a remarkable tool to improve the appearance of skin. In our experience, sustainable results are seen quickly. My initial experience was treating only my left forearm, keeping my right arm as a control. Within 5 days, a noticeable difference in the texture and color of my arms could be seen. I continued to use the product on my arm for 6 weeks, the results of that treatment are still apparent years later. Showing the effects of DefenAge on my arm has been an impressive way to demonstrate the efficacy of the product line. DefenAge is one of our most requested brands,'

- Janice Pastorek, BSN, RN, New York City




Opinions and Stories


Top 10 Dermatologist Recommended Skincare Commandments

by Veronica Webb, supermodel mom and influencer

Want to know how 56-year-old supermodel Veronica Webb’s anti-aging clean beauty secrets? 90’s cover girl and runway star spills the tea on her top 10 ten skincare commandments. Get the scoop on science-backed clean beauty skincare advice from the world’s best dermatologists from Paris to Park Ave. Read more ...


The Secret to Smaller Pores

by Nicole Pearl Kaplan, beauty editor and lifestyle expert

One of the keys to younger looking skin is having tiny pores. One expert reveals a few tricks you can implement to shrink your pore size. This starts with following a specific skincare routine that includes a detoxifying face mask and choosing the right sheets to aide your skin while you sleep. Read more ...


When Dermatologists Talk, I Listen

by Cheryl Kramer Kaye, beauty & fashion writer

Where do you go for your skin-care product advice? Many of us scan our Instagram feeds, read user reviews, or take suggestions from facialists. But according to one beauty pro, you should look to a dermatologist to help guide your decisions. Here’s why. Read more ...


Take Luxurious Care of Your Skin at Home with Premium Products From DefenAge

If you want to upgrade your skin care routine and embrace naturally radiant-looking skin, look at products from DefenAge. From cleansing and moisturizing to exfoliating and reducing the appearance of fine lines, you’ll be treated to innovative and effective products. With Age-Repair Defensins in DefenAge’s effective skin care formulas, you can encourage brand-new, healthy skin cells. Suitable for all skin types, DefenAge products are advanced anti aging skin care. Read more ...


Discover Powerful Dermatologist Recommended Skin Care Products From DefenAge

When you want a skin care regimen that helps diminish visible signs of aging and supports smoother-looking skin, try DefenAge’s signature Clinical Power Trio. The trio of dermatologist recommended skin care products includes 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 2-Minute Reveal Masque. Their formulas feature DefenAge’s proprietary Age-Repair Defensins technology, which can be an alternative to strong retinol creams. All of the DefenAge products are rigorously tested for efficacy and safety so that you can promote lasting results with your very own Clinical Power Trio.



24/7 Barrier Balance Cream

STEP TWO | 24/7 Barrier Balance Cream

Daily: AM | PM

Twice daily after cleansing, place up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage with fingertips over entire face. Avoid eye area. Wait 30 seconds; then apply STEP THREE (8-in-1 BioSerum).
Suitable for all skin types.



8-in-1 BioSerum

STEP THREE | 8-in-1 BioSerum

Daily: AM | PM

Apply after 24/7 Barrier Balance Cream.

30 seconds after applying STEP TWO, place 1 pump of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.



2-Minute Reveal Masque

1-2 Xs A WEEK | 2-Minute Reveal Masque

Once or twice a week after cleansing, dry skin thoroughly. Apply a dollop of masque about the size of a quarter to face and jawline. Using dry fingertips, gently massage masque in a circular motion for 20 seconds or less depending on skin sensitivity. Avoid eye area. Wait 2 minutes. With moistened fingertips, massage until crystals are completely dissolved. Rinse face thoroughly. Follow with STEP TWO (24/7 Barrier Balance Cream).
Not recommended for acne, extremely sensitive or abraded skin.




For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


We are rigorously testing all our products for efficacy and safety. The Clinical Power Trio, its individual products and our signature ingredient Age-Repair Defensins, has been tested in 11 clinical studies by today. All products have been tested by Board Certified Dermatologists, and the 8-in-1 BioSerum, which is recommended to be applied on the areas around the eyes, was also tested by a Board Certified Ophthalmologist. All clinical studies returned outstanding safety and efficacy profiles; the data is published in peer-review clinical journals and presented on dermatologist and aesthetic medical conferences.


The largest multi-center, placebo-controlled clinical study, which tested the Clinical Power Trio, underwent a review of independent Institutional Review Board and is published in the Journal of Drugs in Dermatology. The full text of the article and study results are available on the journal’s website. Based on the results of this study, dermatologists recommend defensins as an safe and efficient alternative to the cosmetic retinol. The study also proved the performance of Clinical Power Trio as an universal anti-aging skin care that addresses visible signs of skin aging on a global scale. Please visit Our Story page for before and after images and details about the multi-center study.



  1. Taub A, Bucay V, Keller G, Williams J, Mehregan D. Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation. J Drugs Dermatol. 2018 Apr 1;17(4):426-441. PMID: 29601620.
  2. Duncan DI. Microneedling with Biologicals: Advantages and Limitations. Facial Plast Surg Clin North Am. 2018 Nov;26(4):447-454. PMID: 30213426.
  3. Taub AF, Pham K. Stem Cells in Dermatology and Anti-aging Care of the Skin. Facial Plast Surg Clin North Am. 2018 Nov;26(4):425-437. PMID: 30213424.
  4. Keller G. Topically Applied Defensins for Comprehensive Improvement of Aging Skin. The American Academy of Facial Plastic and Reconstructive Surgery/COSM – Book of Abstarcts. 2016 A021.
  5. Multi-Center, Double-Blind Clinical Study Validates DefenAge® As A Best-In-Class Anti-Aging Solution, Naturally Turning Back The Clock. Business Wire. 2018 Apr 03. Press Release.
  6.  The Aesthetic Awards Introduces Peer Voting At Ninth Annual Ceremony. 2019 Sep 17. The Aesthetic Guide.
  7.  The Aesthetic Show Annual Awards Ceremony Honors Aesthetic Innovators And Influencers. 2018 Sep 19. The Aesthetic Guide.

Learn More ►

Dermatologist Recommended Skin Care | Core Regimen



Age-Repair Defensins® | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

Hyaluronic Acid

Liposome Encapsulated (Cream) | Low Molecular Weight (Serum)

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


We have carefully formulated our products to exclude multiple harmful and questionable ingredients. In addition to DefenAge’s standard list of the excluded ingredients, products in this kit do not contain fragrance. DefenAge’s standard list of the excluded ingredients is shown on our Clean Beauty page.


The tubes and box are fully recyclable, please recycle.

Not tested on animals.


The detailed ingredient lists are shown on the individual product pages:


24/7 Barrier Balance Cream | No Fragrance Added ►

8-in-1 BioSerum | No Fragrance Added ►



Quality guaranteed ONLY when sold by or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



This product is qualified for the Money Back Guarantee.
Return Policy ►


What is difference between the Clinical Power Trio and Clinical Power Trio+?
The Clinical Power Trio+ contains a MEGA size of the 8-in-1 BioSerum (1.5 oz), while the Clinical Power Trio contains the standard size of the 8-in-1 BioSerum (1.0 oz). Other than that, both Trios are identical.
Is it safe to use the 2-Minute Reveal Masque daily?
No, please use our 2-Minute Reveal Masque only once or twice a week after cleansing. Our masque physically and chemically exfoliates your skin. Too much exfoliation can dry out your skin and cause other issues, including: irritation, redness, tightness, acne, flaky/patchy skin, increased oil production, and shiny-looking skin. Please note that our masque is not recommended for acne, extremely sensitive or abraded skin.
Why is it important to have a skincare routine?
A skincare routine is important for everyone because our skin needs to be taken care of, just like the rest of our bodies. A good 3-step skincare routine can slow down the signs of aging while revealing healthier, more youthful-looking skin.
Why is a simple skincare routine better?
When it comes to skincare, less is sometimes better; most people don’t need to use 12 products in their skincare routine. In fact, too many products can counteract each other or cause skin irritation. Additionally, the more steps in your skincare routine, the less likely you will stick with it or do it daily. A simple 3-step skincare routine, such as our Clinical Power Trio, is a great place to start when getting into skincare. You can add a few different products to address specific issues, like eye cream or acne treatments, to round out your routine.
What is considered medical-grade skincare?
Medical-grade skincare products are specifically formulated to target and treat skin issues like acne or wrinkles. While over-the-counter skincare products can also help with these issues, medical-grade skincare has a higher concentration of active ingredients, making them more effective in a 3-step skincare regime. Additionally, most medical-grade skincare can only be purchased from your dermatologist’s office; however, you can also buy some medical-grade skincare products online.
Why should you use medical-grade skincare?
In addition to having a higher concentration of active ingredients, there are many benefits of using medical-grade 3-step skincare products. These benefits include: Proven formulas — Medical-grade skincare products are developed with a more in-depth process and have a high standard for ingredients to create real results. Dermatologist overview — To get medical-grade skincare products, you need to purchase them from your doctor’s office. This means they can supervise the results and determine how products work as part of your skincare routine. Better value — While medical-grade skincare products may cost more, you’re actually getting a better value for the price. This value comes from these products showing proven results, meaning you’re getting what you paid for. Plus, you may be able to use these products less over time once you achieve desired results. Better ingredients — The FDA requires medical-grade skincare products to contain 99% pure ingredients, which ensures these products work better and are overall better for your skin.
How do I know if my skincare is working?
It will depend on your desired results, but one of the biggest indicators that your skincare routine is working is if your skin is happy. Meaning no redness, irritation, or dryness. Here are some additional signs of a good skincare routine: Skin looks more even, your acne is reduced or gone, rough skin now feels smooth and your skin feels hydrated and look fuller. Our Clinical Power Trio helps correct visible signs of skin exhaustion, damage, and aging on a global scale. You should see improvement and reduction of multiple skin concerns simultaneously. Our Clinical Power Trio truly is an all-in-one kit.
How long does the Clinical Power Trio last?
If used as recommended, the Clinical Power Trio lasts for 4-8 weeks and is enough to see a full range of results, although all people are differenet and individual results may vary.