Value pack is available. SHOP HERE


Value pack is available. SHOP HERE

/ $138.00 with free account /
Good Housekeeping Award: Best in Best-in-Class Body

If you ever mused aloud, "I wish I could slather my entire body with DefenAge," then the new 10 Luxe Hand & Body Cream answers your call. According to key opinion leaders in aesthetic medicine, our new regenerative anti-aging lotion for crepey skin delivers much more than a product that simply feels soft to the touch. Expert opinions


  • •  Visibly enhances firmness and cosmetic elasticity.
  • •  Improves the appearance of crepey skin.
  • •  Refines the surface skin texture.
  • •  Provides both instant and long-lasting hydration including in dry climates. Boosts natural moisture retention. Skin feels firmer and plumper immediately.
  • •  Relieves the feeling of dryness and itching.
  • •  Balances the skin’s barrier function.
  • •  Promotes the skin’s natural hyaluronic acid, laminin, and elastin.
  • •  Improves visible skin thickness.
  • •  Reverses signs of skin aging, premature aging, and sun damage.
  • •  Effective on elbows and knees; visibly revives their smooth texture and revitalizes softness.
  • •  For use as an anti-aging hand lotion, it smooths and softens the skin on the hands.
  • •  Keeps skin glowing all over the body.
  • •  Beneficial in combination with body contouring procedures to improve visible skin firmness and overall skin quality.
  • •  Recommended in pairing with skin rejuvenation treatments (i.e., peels, IPL, microneedling, and lasers) to amplify results in the reduction of the look of pigmentation, sun damage, crepeness, and mild skin laxity.


Why it’s different

  • • Contains defensin-molecules. Encompasses 7-year knowledge and research collected on the clinical performance of defensins compared to retinol anti-aging tightening lotions.
  • • Provides anti-aging benefits on a global scale.
  • • Promotes new ‘younger’ skin.
  • • Effective on both the hands and body.
  • • Fast acting: first results from ‘immediate’ to 1 week, full range of results in 6 weeks.
  • • Non-irritating retinol alternative. Delivers retinol-like results.
  • • Rich luxurious texture, elegant feel, clean smell of natural ingredients. Fragrance free.
  • • Absorbs quickly, not sticky or tacky, and does not leave a greasy feeling.
  • • Four-pillar formulation strategy:
  • Global anti-aging (defensin-molecules)
  • Natural moisturization & comprehensive barrier repair (Ophiopogon japonicus root extract, Sinorhizobium meliloti ferment)
  • Soothing & calming via anti-inflammation (sea whip, panthenol)
  • DefenAge’s hero blend of ingredients proven to be well-paired with defensins (including niacinamide and squalane)
  • • Advanced clean beauty standards, No PEGs or animal- or human-derived ingredients.
  • • Developed in response to demand by the medical community, aesthetic service providers, and customers.


Made in the U.S.A.




DefenAge Unveils First-Ever Body Cream Containing Defensin-Molecules

Carlsbad, CA – September 01, 2021 – DefenAge® Skincare, manufacturer and distributor of revolutionary, evidence-based, anti-aging products, today announces the launch of its long-awaited 10 Luxe Hand & Body Cream, developed in response to the demand by aesthetic medical professionals and customers. Infused with DefenAge’s famed and exclusive defensin-molecules, the new hand and body cream bathes skin in the most powerful age-reversal skincare technology on the market. Read more




10 Luxe Hand & Body Cream | Anti-Aging Firming Lotion

STEP TWO - BODY | 10 Luxe Hand & Body Cream 

Daily: AM | PM

Apply once or twice daily after showering or bathing. Smooth and lightly massage the cream from ankles to waist, then hands, arms, and shoulders, followed by rest of the body. Apply 8-in-1 BioSerum on elbows, knees, and other challenging areas to maximize results.

Suitable for all skin types.




For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The 10 Luxe Hand & Body Cream is dermatologist tested.


Robust Multi-Function

"I love it. It is rich, and penetrates well, and I love that the pump gives you a lot in one draw. Most anti-aging body creams just make a simple lotion and add their hero ingredient. By creating a body cream with barrier repair and anti-inflammatory ingredients in addition to defensins, the 10 Luxe Hand & Body Cream gives me confidence I am recommending the very best anti-aging body cream to my patients due to its robust multi-function."

- Dermatologist Amy Forman Taub, MD


"The new DefenAge body cream addresses an unmet need in the beauty industry. It has the same evidence-based science as the legacy products. It takes advantage of anti-aging ingredients paired with the defensin-molecules to revive aging skin."

- Dermatologist Sue Ellen Cox, MD


"I’m a surgeon and wear sterile gloves for hours. My hands and fingers often become irritated. Use of the new 10 Luxe Hand & Body Cream has relieved the irritation and left my hands soft and smooth."

- Plastic Surgeon Gregory Keller, MD


Crepey Skin | Study

"Our patients have been waiting for a topical solution to address crepey skin that actually does more than a store-bought moisturizer. I finally have a scientifically proven option with DefenAge’s 10 Luxe Hand & Body Cream. In our split inner arm and lower thigh testing, patients have seen a difference on the treated side within 2 weeks that continues to improve over the next 12 weeks."

- Dermatologist Suneel Chilukuri, MD


"So many patients are complaining about creping changes to their arms and legs, and while previously I suggested they use a pump of DefenAge 8-in-1 BioSerum mixed with their favorite body lotion, the new body cream will encourage the use of body-specific products instead of trying to fit facial products on body areas."

- Dermatologist Steven Swengel, MD


"After trying the 10 Luxe Hand & Body Cream, my dry skin instantly looks and feels better; it is perfect for crepey skin, especially in a dry climate. The defensin-based technology can actually reverse the appearance of aging skin, so much so that areas that might otherwise be covered, such as the upper arms, elbows and knees, can now be exposed again. The texture is perfect, thick enough without feeling too heavy. Application is smooth without feeling greasy.I plan to pair the 10 Luxe Hand & Body Cream with BBL Hero (Sciton) treatments. The device by Sciton can reduce pigment, sun damage, crepiness, and mild skin laxity in a manner similar to using DefenAge post microneedling. The thermal effect of the device on skin will be amplified by the post-treatment application of the DefenAge body cream. I plan to instruct patients to use the 10 Luxe Hand & Body Cream two to three times a day following four weekly treatments with the BBL."

- Plastic Surgeon Diane Duncan, MD


'Immediate' effect

"I am thrilled to introduce the 10 Luxe Hand & Body Cream to my patients. The feeling is elegant. The smell is pleasant and clean. It absorbs fairly quickly and is not at all sticky or tacky. It moisturizes, hydrates, and immediately, the skin feels firmer and plumper. I only recommend skincare products that are backed by science. All DefenAge products, including the new body cream, contain ingredients that are clinically proven to rejuvenate, hydrate, and brighten skin."

- Dermatologist Melda Isaac, MD


Elbows and Knees

"The defensin-based technology can actually reverse the appearance of aging skin, so much so that areas that might otherwise be covered, such as the upper arms, elbows, and knees, can now be exposed again."

- Plastic Surgeon Diane Duncan, MD


"Being almost 60, with gardening as a hobby, kneeling and using my gardening tools caused my knees and arms to become rough and almost ‘calloused.’ I saw a dramatic improvement in my crepey skin and roughness just a few days after I started using DefenAge’s new body cream. There is no doubt that I will recommend my patients to use the 10 Luxe Hand & Body Cream on their elbows and knees, who are already asking how I got such an improvement."

- Partner at Keller Plastic Surgery Pamela Keller, RN


Safe Retinol Alternative

Dermatologist Stephen Friedman, MD, of Malibu, California, conducted a dorsal arm bilateral comparison of the 10 Luxe Hand & Body Cream to an advanced retinol-containing body lotion, additionally supplemented with hydrating and barrier repair ingredients. Dr. Friedman concluded that DefenAge’s new body cream produced comparable clinical benefits to the retinol lotion. “In the brief open clinical trial, there is no perceptible difference in the appearance of the right and left dorsal arms. The degree of hydration, texture, and color were identical.”

- Dermatologist Stephen Friedman, MD


Pairs With Body Contouring Procedures And Skin Rejuvenation Treatments

"The non-surgical body contouring industry is increasing significantly. The 10 Luxe Hand & Body Cream with defensin technology has been shown to improve the quality of the skin long after we reduce the patient’s fat and tone their muscle. Defensins help us to ‘ice the cake’ on the patient’s overall quality of the result. It has been a welcome addition to my armamentarium of body treatments. It also fits into our new ‘biostimulatory’ story for skin improvement. I have been using defensin technology in my offices since the inception of DefenAge. My patients made me a believer, as without exception any patient who uses DefenAge sees an improvement in the tone, quality, and clarity of their skin."

- Facial Plastic and Reconstructive Surgeon Gregory Chernoff, MD


"The new DefenAge 10 Luxe Hand & Body Cream is a very exciting addition to this incredibly luxurious and effective line of skincare products. Like the face and neck products, the body cream contains the coveted defensins in addition to a strong lineup of active ingredients to target stubborn crepey skin on the body, while enriching the skin barrier and providing excellent emollition. When used alongside radiofrequency microneedling, such as Cutera Secret RF, which is one of my go-to procedures for firming and resurfacing of arms, legs, abdomen, and more, the DefenAge body cream ingredients add anti-aging benefits while simultaneously ameliorating the healing process. I cannot wait to offer this innovative product to my patients."

- Dermatologist, Jessica Weiser, MD


A Must Have Product

"We consider DefenAge an essential skincare product. The new 10 Luxe Hand & Body Cream is a wonderful addition that we will all be using! It has a great texture, is an excellent moisturizer, and improves both the sun damage and aging part of our skin."

- Dermatologist Angela Bowers, MD


"DefenAge has been working on developing, improving, and refining defensin skincare technology over the last 7 years. I have had the pleasure of being not only a happy consumer of all of their products, but also a board-certified cosmetic dermatologist who has seen the entire product line grow with impressive product after product with cutting-edge technologies that I have had the pleasure of sharing with many patients who have benefited from this exclusive skincare. From the face to the eyes to the neck and décolleté, DefenAge has changed the way we view the possibilities for topical skincare, and similarly the way in which we see ourselves every day in the mirror. The time has arrived to ‘turn the clock back’ with DefenAge on aging hand and body skin just as we have been doing already with other DefenAge products on our faces, eyes, and neck. After reviewing the science, it is easy to understand why DefenAge’s new hand and body cream feels great when applied to the skin, relieves dryness and itching (even in dry, sensitive skin like mine), and enables moisturization that lasts and lasts while contributing to anti-aging and improving the look and feel of the skin itself. It is with great enthusiasm that I welcome the 10 Luxe Hand & Body Cream. For many of us… it has been a long-awaited arrival!"

- Dermatologist Natalie M. Curcio, MD, MPH


"My patients are looking for effective anti-aging solutions for the face and the body. With the new DefenAge body cream, they have an option that goes beyond typical moisturizers to improve the appearance of their skin and help to reverse the aging process."

- Dermatologist, Anne Chapas, MD


"DefenAge’s Body Cream meets the long-awaited need for a body cream that is both an effective anti-aging product as well a luxurious, feel-good product. The addition of this cream to the curated products aesthetic practices carry in-house is a must"

- Aesthetic Physician, Monica Bonakdar, MD


Advanced Skincare

"The future of Aesthetics is regenerative medicine, and this includes new advances in skincare products. DefenAge’s new body cream reprograms your dormant cells to create new skin cells from head to toe. My skin is now mainly comprised of young cells,and it shows."

- Dermatologist Shino Bay Aguilera, MD


"As a dermatologist who strives to care for both the medical and cosmetic concerns of my patients, good skincare is not limited to the face and neck. It includes the entire body. An ingredient and evidence-based approach to skincare makes sense to me and allows me to explain the benefits of a particular product to my patients. Several years ago, I became a fan of DefenAge, an innovative skincare line that leverages defensins, molecules that have the ability to stimulate a subset of dormant stem cells to create a more youthful epidermis. A few months ago, I had the opportunity to try DefenAge’s 10 Luxe Hand & Body Cream, which feels very lightweight and absorbs quickly while still delivering long-lasting hydration. What really appeals to me are the 4 pillars that are the foundation of the formulation: anti-aging on a global scale provided by defensins; hydration and barrier repair by Ophiopogon japonicus root extract and Sinorhizobium meliloti ferment; soothing and calming by sea whip and panthenol; and a hero blend of ingredients that are compatible with defensins, including niacinamide (aka multitasking vitamin B3 that plays a key role in skin immunology, barrier function, and pigmentation, to name a few) and squalane"

- Dermatologist Vivian Bucay, MD



Source: Backed by Science, New Body Cream Redefines Expectations of Aesthetic Medical Professionals | Dermatology Times 



Age-Repair Defensins® | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


firmness & elasticity • brightening • hydration

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone. It is a part of DefenAge's hero blend of ingredients that are well established to work together with defensins.


Sea Whip

skin calming & soothing • double-dose

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea. The 10 Luxe Hand & Body Cream contains an amplified concentration of Sea Whip.

Ophiopogon Japonicus Root Extract and

Sinorhizobium Meliloti Ferment

skin's barrier balance • natural hydration

Our “know-how”-protected, advanced, and powerful blend of natural extracts balances the skin’s barrier, save the skin’s natural moisture, and promote the levels of Natural Moisturization Factors (NMFs).



moisturization • antioxidant 

Energizes skin hydration. Prevents moisture loss while restoring visible skin’s suppleness and flexibility. Fights skin damage and free radicals.




soothing • protection

Helps the skin build up a barrier against irritation and improves visible elasticity and smooth appearance. Hydrates the skin from within. Proven humectant.



The body cream formula exceeds most, if not all, industry and beauty standards for clean skincare. In addition to the extended list of ingredients that are restricted for use in DefenAge, the 10 Luxe Hand & Body Cream also does not contain silicones, PEGs, and is free from fragrance. To learn more about DefenAge’s clean skincare standards, please visit our Clean Beauty page.


The bottle and box are fully recyclable, please recycle.

Not tested on animals.


10 Luxe Hand & Body Cream

Water (Aqua), Aloe Barbadensis Leaf Juice, Butyrospermum Parkii (Shea) Butter, C13-15 Alkane, Caprylic/Capric Triglyceride, Propanediol, Sinorhizobium Meliloti Ferment Filtrate, Niacinamide, Cetyl Alcohol, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Stearyl Alcohol, Simmondsia Chinensis (Jojoba) Seed Oil, Squalane, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Sea Whip Extract, Tetrahexyldecyl Ascorbate, Ophiopogon Japonicus Root Extract, Tocopheryl Acetate, Panthenol, Kappaphycus Alvarezii Extract, Caesalpinia Spinosa Fruit Extract, Ubiquinone, Albumin, l-Alanyl-L-Glutamine, Palmitic Acid, Sodium Stearoyl Glutamate, Glycerin, Methyl Glucose Sesquistearate, Polyacrylate Crosspolymer-6, Cetyl Hydroxyethylcellulose, Lecithin, Leuconostoc/Radish Root Ferment Filtrate, Phytic Acid, Sodium Phytate, Caprylhydroxamic Acid, 1,2-Hexanediol, Sorbic Acid, Sodium Chloride.



Quality guaranteed ONLY when 10 Luxe Hand & Body Cream is sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



10 Luxe Hand & Body Cream is qualified for the Money Back Guarantee.
Return Policy ►


Can I layer this product with other products?
Yes, in fact when you add DefenAge to any existing skincare regimen, results are enhanced as a result of the Defensin-molecules that trigger the body’s natural response to activate new skin cells creating noticeable improvement in tone, texture and radiance.
How long will it take to see results?
Results can be seen from immediate to 1 week and the full range results can be see in 6 weeks.
What helps with dry, wrinkled hands?
If you’re suffering from the discomfort of dry hands, elbows, knees, or other body parts and struggle with your confidence due to aging skin, an anti-aging body lotion is exactly what you need. Not only can a hand and body cream alleviate the itching and discomfort associated with dryness, but it can also plump and hydrate skin with a crepey appearance.
Is anti-aging hand cream important?
While you’re young, you probably don’t give much thought to your hands. But as you grow older, the skin on your hands slowly begins to wrinkle and show signs of your age. For many adults, this is a cause for insecurity. Anti-aging hand cream is important to start using early in life, so your skin is slower to age. As you keep your hands moisturized regularly, you’ll enjoy youthful, healthy skin for longer.
When should you start using hand and body cream?
It’s never too early to start using a hand and body lotion. In fact, the earlier, the better! People of any age can reap the benefits of moisturized skin — especially those who live in extremely hot, cold, or dry climates. Every time you shower or wash your hands, dry them thoroughly and follow them up with a moisturizing hand and body cream to lock in moisture and prevent the dryness that leads to wrinkles. Keep some hand cream within arm’s reach in your backpack, car console, desk drawer, bathroom, purse, and anywhere else you might need it for instantly softer skin.
What type of firming body cream do dermatologists recommend?
Dermatologists advise the use of products that have been tested by skincare professionals for efficacy and safety. When the medical community approves a skincare product, it means that skincare doctors have used it themselves or on a patient and experienced good results. Seek out a dermatologist-tested anti-aging body lotion with wholesome ingredients that have proven to be effective in clinical trials.
How long does it take for anti-aging body cream to work?
You should start to feel a difference in your skin's hydration level within minutes. The 10-Luxe Hand & Body Cream provides both instant and long-lasting hydration including in dry climates. It's fast-acting; first results tend to appear one week after the first use, with the full range of results becoming visible in six weeks. It boosts natural moisture retention and skin will feel firmer and plumper immediately. You’ll still need to reapply consistently, so the moisturizer has a chance to heal and repair cracked, dehydrated skin and the Age-Repair Defensins® have a chance to stimulate new skin. TIP: Exfoliate skin to see results faster. DefenAge's exfoliation solution is the 2-Minute Reveal Masque. You can get our 10 Luxe Hand & Body Cream and 2-Minute Reveal Masque + our 8-in-1 BioSerum for a discounted price in our Ultimate Hand Trio.
What’s the best way to apply anti-aging hand cream?
After cleansing, start by applying a dime-sized amount of the best lotion for aging skin to the back of your hand. Rub together until no hand cream remains, making sure to cover the knuckles and other areas of the hands that are prone to dryness. For optimal results, wear gloves on your hands overnight to ensure all the cream is absorbed into the skin.
How do you stop your skin from aging?
There are many measures you can take on a daily basis to help slow down the signs of aging. You have probably heard of and practice most of them: applying sunscreen daily, eating healthy foods, staying active, drinking plenty of water, managing your stress levels, and getting enough sleep. You also want to make sure you are using effective anti-aging skin care products, such as DefenAge's range of cleansers, creams and serum with defensins. The Age-Repair Defensins® help regenerate and make skin grow young again by triggering a backup copy of young skin cells that our body already possesses.
How do I get rid of dry skin on my elbows and knees?
Firstly, avoid using alkaline soaps and surfactants. Moisturize daily with a lotion for dry skin, such as our 10 Luxe Hand & Body Cream which is effective on elbows and knees by visibly reviving their smooth texture and revitalizing softness. Gently exfoliate your skin to remove dead skin cells. Our 2-Minute Reveal Masque can help with this step. Nourish your skin from the inside out with proper nutrition and hydration.
Why are my elbows dark and rough?
People who have naturally darker skin tones are more likely to develop dark elbows. According to the American Academy of Dermatology, a condition or substance that triggers the skin to create additional melanin can cause dark spots and patches on the skin. Melanin is the substance responsible for giving skin its color.
What is the best thing to do for crepey skin?
You want to use an effective anti-aging body moisturizer daily, such as our 10 Luxe Hand & Body Cream. It contains Age-Repair Defensins® to promote new skin, shea butter for ultimate hydration, Ophiopogon Japonicus Root Extract and Sinorhizobium Meliloti Ferment to help balance the skin’s barrier, and a double-dose of skin soothing sea whip. This lotion for aging skin is beneficial in combination with body-contouring procedures to improve visible skin firmness and overall skin quality. We recommended pairing our firming body cream with skin rejuvenation treatments (i.e., peels, IPL, microneedling, and lasers) to amplify results in reducing the look of pigmentation, sun damage crepiness, and mild skin laxity. If you do opt for a medical procedure, you would definitely want to use our body cream to prepare your skin for the procedure and for maintenance of the skin after the procedure.
What ingredients should I avoid in a lotion for aging skin?
Skincare science has found that ingredients such as parabens, fragrances, synthetic dyes, retinol, alcohols, and mineral oil can be irritating and damaging to the skin. The best body lotion for aging skin will not contain any of these substances but will instead be formulated with antioxidants, moisturizing agents, retinol alternatives, and nourishing ingredients from nature.