Unlock the Power of 8 Serums In 1. Shop Now!
Unlock the Power of 8 Serums In 1. Shop Now!
8-IN-1 BIOSERUM | VIP Trial - Mailer

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

This product is covered by U.S. Patent No. 11,491,096.

8-IN-1 BIOSERUM | VIP Trial - Mailer

Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.

This product is covered by U.S. Patent No. 11,491,096.

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The Multifaceted Anti-Aging Serum

Embrace the extraordinary capabilities of the 8-in-1 BioSerum, our multifunctional marvel in anti-aging skincare. Intuitively meeting your skin’s unique needs, this DefenAge's iconic bestseller is designed to deliver visible, targeted rejuvenation. As a biologically advanced serum concentrate, it features an unprecedented concentration of defensin molecules from the Age-Repair Defensin® Complex, affirming its position as a superior anti-aging serum. Esteemed by dermatologists as an excellent retinol alternative, the 8-in-1 BioSerum serves as a premier rejuvenation serum, either alone or in combination with retinol or bakuchiol serums. Experience the cumulative benefits of eight distinct serums and unveil your best skin ever with this rejuvenating serum.

The Standalone Skincare Wonder

Ideal as a solo skincare powerhouse, the 8-in-1 BioSerum is renowned as a "treatment multiplier" and likened to "microneedling in a bottle." Dermatologists recommend this rejuvenation serum for enhancing the results of aesthetic procedures such as microneedling, RF-microneedling, fractional and ablative laser treatments, and Sofwave. Explore how this anti-aging serum can amplify your treatment outcomes in the Clinical Studies tab.

Read expert opinions here.

Eight Serums in One: Embark on a Journey of Eightfold Rejuvenation

Dive deeper into the unique fusion offered by the 8-in-1 BioSerum. This innovative formula masterfully brings together the benefits of eight specialized serums, delivering a holistic approach to skincare that’s comprehensive and unparalleled:

  • 1. Anti-Oxidants Serum: A robust blend of antioxidants, including Ergothioneine, combats environmental damage while brightening and energizing the skin.
  • 2. Niacinamide Serum: Rich in high-performance Niacinamide (Vitamin B3), it soothes, hydrates, revitalizes the skin’s moisture barrier, and promotes a uniform skin tone.
  • 3. Hyaluronic Acid (HA) Serum: Infused with low-weight Hyaluronic Acid for deep hydration, supplemented by a suite of intense moisturizers.
  • 4. Collagen Serum: Enhanced with beta-defensin 3, the BioSerum boosts collagen, improves elasticity and firmness, and diminishes sagging.
  • 5. Calming Serum: Contains Sea Whip extract, the sea’s most potent and swift anti-inflammatory agent, effectively addressing inflamm’aging.
  • 6. Peptide Serum: A bespoke blend of peptides, including Palmitoyl Tripeptide-38, targets critical aging areas, smoothing wrinkles and refining skin texture.
  • 7. DNA-Repair Enzyme Serum: Features enzymes from Mediterranean Arabidopsis, renowned for repairing common DNA damage.
  • 8. Retinol-Alternative Serum: The crowning jewel of the 8-in-1 BioSerum is the highest concentration achievable of Alpha-Defensin 5—DefenAge’s exclusive and revolutionary ingredient. This bio-synthesized molecule marks a triumph in regenerative biology, renowned for its unparalleled ability to activate age-repair pathways, foster new skin development, and serve as a safe, highly effective alternative to retinol. The inclusion of Alpha-Defensin 5 represents not merely an advancement in skincare, but a paradigm shift in our approach to skin rejuvenation and anti-aging. The presence of this potent ingredient in the serum parallels the benefits of traditional retinol serums with a gentler approach, minimizing potential irritation and making it suitable for all skin types.

The 8-in-1 BioSerum transcends traditional skincare, unifying eight essential benefits for a youthful, radiant complexion. It's not just an anti-aging serum; it’s a complete solution for visible skin rejuvenation.

How Our BioSerum Works: The Essence of Anti-Aging and Rejuvenation

Experience the transformative effects of DefenAge's 8-in-1 BioSerum, an exceptional anti-aging and rejuvenation serum. This unique formula improves the overall health and appearance of your skin by:

  • •  Rejuvenating Smoothness: Enhancing visible skin health and quality.
  • •  Reducing Signs of Aging: Minimizing the look of fine lines, wrinkles, pores, and pigmentation.
  • •  Promoting Radiance: Reviving skin’s natural moisture for a luminous glow.
  • •  Brightening Skin Tone: Improving overall clarity and luminosity.
  • •  Renewing the Feeling of Firmness and Elasticity: Restoring texture for a youthful feel.
  • •  Calming Redness: Beneficial for sensitive skin, Helps improve the appearance of skin redness.
  • •  Promoting Skin Barrier and Immunity: Helps to Strengthen skin’s natural defenses for optimal health.

Why Choose Our 8-in-1 BioSerum: A Cut Above the Rest

Our rejuvenation serum stands out as a superior alternative to retinol and bakuchiol serums. The 8-in-1 BioSerum combines advanced, targeted treatment with validated science, creating an unparalleled skincare product:

  • •  Rich in Defensins: Contains five times more defensin molecules than other skincare formulas.
  • •  Feather-Light Feel: Offers a lightweight application for a comfortable wear.
  • •  Versatile Use: Safe and effective for the entire face, skin around eyes, lips, neck, and décolleté.
  • •  Targets Crepey Skin: Excelling on thin skin areas like the neck and arms.
  • •  Rapid Anti-Aging Effects: Delivers visible results within a few weeks.
  • •  Suitable for All: Ideal for daily use, for both men and women, and for all adult ages, including people above 70.
  • •  Gentle for Sensitive Skin: Non-irritating, retinol.
  • •  Broad Tolerance: Effective for diverse skin types, including those with rosacea and melasma.
  • •  Highly effective for pre- and post- aesthetic procedures: Enhances outcomes of aesthetic treatments like microneedling, fractional and ablative laser therapy. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
  • •  Pre-Filler Prime: Ideal for preparing skin before fillers — start using four to six weeks before procedures.
  • •  Customer Favorite: Known as DefenAge's most liked product with impressive feedback.

Made in the U.S.A.

Add These Moisturizers to Your BioSerum Routine:

Ten Specific Ways Leading Dermatologists Recommend Using the 8-in-1 BioSerum:

  1. For daily use. It’s lightweight. “You can’t even feel it when you’re wearing it.” Dermatologist Vivian Bucay, MD
  1. For sensitive skin. It delivers anti-aging results but it’s “not irritating like a retinol or acids.” Dermatologist Anne Chapas, MD
  1. For older age. Even old skin has young dormant cells that can be turned on by defensins. “We saw a marked difference at 2 months” in a 73-year-old patient. Dermatologist Angela Bowers, MD
  1. For better skin quality, including firmer skin, fewer fine lines, more luminosity and clarity, and a reduced appearance of pores. Dermatologist Anne Chapas, MD
  1. After microneedling, patients are “less likely to break out with acne post treatment.” Dermatologist Vivian Bucay, MD
  1. “4 to 6 weeks before having filler procedures” to prep the skin and enhance results. Dermatologist Kathleen Welsh, MD
  1. Before and after ablative skin treatments, which “primes skin to respond more quickly and robustly, healing faster.” Dermatologist Steven Swengel, MD
  1. To target specific areas, including around the eyes and lips. Dermatologist Angela Bowers, MD
  1. Beyond the face: on the neck and décolleté. Dermatologist Steven Swengel, MD
  1. For crepey thin skin on the neck and arms. Dermatologist Kathleen Welsh, MD

Dermatologists weigh in on DefenAge’s 8-in-1 BioSerum: Patient outcomes, optimal use. The Dermatology Digest (2021) January, p. 40-42.

FAQ: What makes this serum effective for anti-aging and rejuvenation?

The effectiveness of our 8-in-1 BioSerum in anti-aging and rejuvenation stems from its unique blend of potent ingredients and advanced technology. Central to its formula is the Age-Repair Defensin® Complex, which contains defensin molecules. These bio-synthesized molecules are key to the serum’s effectiveness as they tap into skin's natural regenerative processes. Here's how the serum works to combat aging and visibly rejuvenate your skin:

  • •  Comprehensive Formulation: Unlike traditional serums, our 8-in-1 BioSerum combines the benefits of eight specialized serums in one. Each 'serum' within targets specific aging concerns, from hydration to collagen boosting, offering a complete anti-aging solution.
  • •  Advanced Defensin Technology: The serum's high concentration of Alpha-Defensin 5 and Beta-Defensin 3, exclusive to DefenAge, actively help to rejuvenate skin by promoting new, younger-looking skin and enhancing skin's natural barrier. These molecules are recognized as a safe and effective alternative to retinol, making the serum suitable for even sensitive skin types.
  • •  Multi-Dimensional Benefits: The 8-in-1 BioSerum addresses various visible signs of aging – it smoothens fine lines and wrinkles, improves skin texture, boosts hydration, enhances firmness, and provides potent antioxidant protection. This comprehensive approach ensures visible rejuvenation of the skin.
  • •  Proven Results: Supported by dermatologists and aesthetic professionals, our serum is not just a product but a scientifically-backed solution. Its efficacy in anti-aging and visible skin rejuvenation has been proven through rigorous clinical studies and real-world use.

By integrating these advanced components and science-backed ingredients, the 8-in-1 BioSerum stands out as a highly effective product for both anti-aging and visible skin rejuvenation, delivering noticeable results that are both rapid and long-lasting.

FAQ: How and Why You Should Add the 8-in-1 BioSerum to Your Skincare Regimen?

Dermatologists agree, if you do one nice thing for your skin this year - introduce it to defensin-molecules. Defensins can be incorporated into your existing skincare regimen and do not conflict or compete with other skincare. Whether it’s CHANEL or Clinique, incorporating DefenAge + Defensins can actually enhance the skincare you already know and love.

Consumer survey says that 93% of consumers who use CHANEL

skincare also like the results they see with DefenAge!

/ Survey 2022, data on file /

“Why do CHANEL users like DefenAge? – this is simple – DefenAge’s defensins multiply the effect of other skincare. …Ironically, DefenAge skin care has no competition on the skincare market because it enhances any other skin care brands. Much like laser treatments and microneedling, the topical application of defensins causes our body to message ‘preserved,’ healthy cells to create visibly new skin. I recommend the BioSerum to my patients to activate their “skin’s memory”, triggering skin to look younger, twice a day – in the morning and evening by applying just one drop of DefenAge BioSerum over the moisturizer of their choice,”

-Board-certified dermatologist Natalie M. Curcio, M.D., M.P.H.

Check with us, what other skincare than CHANEL can be combined with DefenAge's defensins for more glowing skin.  

Opinions and Stories

Healthy, Simple, and Safe Skincare Routines with Defensins from Supermodel Veronica Webb

by Veronica Webb, supermodel mom and influencer

Aging powerfully is as much about your attitude as it is about the skincare products you use. Veronica Webb, supermodel, mom, influencer, and beauty writer talks dermatologist recommended anti-aging clean beauty serums, moisturizers, and cleansers. Veronica shares her take simple safe and healthy confidence-boosting skincare routines that make a daily difference. Read more ...

How Effective Is Combining Products From Different Skincare Lines?

by Eliza Cabana, aesthetic and skin rejuvenation guru

Don’t want to give up your Chanel (or other) skincare product for something new? With DefenAge, you don’t have to! One expert explains how you can combine your favorite products with the DefenAge line to get all the benefits of both. Read more ...

The Secret to Effective 'Anti-Aging'

by Eliza Cabana, aesthetic and skin rejuvenation guru

Who doesn’t love a good anti-aging cream? But will it actually turn back the clock for your skin? One expert shares her perspective on the “anti-aging” misnomer as well as tips for what steps you can take to get the most out of your skincare routine. Read more...

Introduce Your Skin to the Benefits of DefenAge’s 8-in-1 BioSerum This Year

DefenAge’s 8-in-1 BioSerum may be lightweight, but it packs more Defensin molecules than any of DefenAge’s other products. Age-Repair Defensins wake up dormant cells to make brand-new, healthy cells. The result is skin that looks brighter, smoother, and firmer. If you don’t want to use retinol, try the dermatologist recommended skin care from DefenAge, including 8-in-1 BioSerum. Age-Repair Defensins are just as effective as retinol. Read more...

How to Get the Best Results From Your Anti-Aging Skin Care Products

The best anti aging skin care products will help your skin look brighter, smoother, plumper, and reduce the appearance of wrinkles. But if you want to truly maximize the product’s effectiveness, there are several things to keep in mind. Using skin care products that address signs of aging is a commitment, but it’s worth it when you start seeing results. Read more...

DefenAge’s Anti-Aging Serum: A Spring Skin Care Must-Have

The 8-in-1 BioSerum, anti-aging serum, from DefenAge is a best-selling product with the highest concentration of Age-Repair Defensins. Defensins are molecules that prompt dormant cells to make brand-new, healthy skin cells. DefenAge is the only brand to use Age-Repair Defensins, a proprietary ingredient. The result is new skin cells that look younger and healthier. DefenAge’s products don’t merely cover signs of visible aging.



8-in-1 BioSerum

Daily: AM | PM

Place a pea-size amount of serum onto fingertips. While skin is still moist, lightly massage with fingertips first around eyes, then over entire face. Use a second drop on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.






For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 7 clinical studies.


The 8-in-1 BioSerum was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.

Additional ophthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.

The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.

All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.

We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile. Because of the exceptional results seen with the use of the 8-in-1 BioSerum and the unique mechanism of action of Defensin-molecules, the 8-in-1 BioSerum is commonly called "microneedling in a bottle."

Before and After

Before and After


Microneedling and RF-Microneedling: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Fractional laser: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Ablative laser: 7 days post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.

Safewave and other non-invasive procedures: Immediately post-procedure, apply Clinical Power Trio for 2-4 weeks.

Before and After

Before and After



Age-Repair Defensins® | 5X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone. The 8-in-1 BioSerum is named 'Best Niacinamide and Hyaluronic Acid Serum of 2024' by Good Housekeeping magazine.

Hyaluronic Acid | Low Molecular Weight

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excused from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.


The package is fully recyclable, please recycle.

Not tested on animals.


8-in-1 BioSerum

Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Sea Whip Extract, Ergothioneine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Offinalis (Rosemary) Leaf Extract, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Albumin, L-Alanyl-L-Glutamine, Caprylic/Capric Triglyceride, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride.
Fragrance free.

This product does not contain retinol and should not be considered as a retinol serum.



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