Unlock the Power of 8 Serums In 1. Shop Now!
Unlock the Power of 8 Serums In 1. Shop Now!
8-IN-1 BIOSERUM | Pack of 3 | 2022

Pack of 3 (Mega Size, 1.5 fl oz)

Holiday PROMO ❄
Shop Gifts At DefenAge!

VALUE Pack of 3:
Third 8-in-1 BioSerum 1.5 fl oz in your shopping bag is FREE!

Holiday Promo


Limited time offer, until December 31st only or until supplies last.

A portion of the proceeds from DefenAge’s holiday sales will go towards a donation to the Monarch School of San Diego.

You can earn 396 points in DefenAge® Skin Club with this purchase.

8-IN-1 BIOSERUM | Pack of 3 | 2022

Pack of 3 (Mega Size, 1.5 fl oz)

Holiday PROMO ❄
Shop Gifts At DefenAge!

VALUE Pack of 3:
Third 8-in-1 BioSerum 1.5 fl oz in your shopping bag is FREE!

Holiday Promo


Limited time offer, until December 31st only or until supplies last.

A portion of the proceeds from DefenAge’s holiday sales will go towards a donation to the Monarch School of San Diego.

You can earn 396 points in DefenAge® Skin Club with this purchase.


Pay as low as $45/mo with Affirm. Use Amazon Pay at Checkout.

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Price above is shown for the bundle of 3 units (VALUE Pack of 3). Each unit in this bundle contains 1.5 fl oz (MEGA Size).

The 8-in-1 BioSerum is DefenAge's iconic bestseller. The remarkably smart formula seems to understand your skin’s needs better than your own DNA. Designed to activate, orchestrate and energize, this biologically-advanced anti aging cream-like serum concentrate provides an unprecedented concentration of defensin molecules contained in the Age-Repair Defensin® Complex. Dermatologists and aesthetic professionals name defensins as a perfect retinol alternative and the 8-in-1 BioSerum as a retinol serum replacement. The best part? Results are equal to 8 separate serums. Apply with the 24/7 Barrier Balance Cream to create smoother, younger looking skin. Patented technology. Get the best skin ever today!

Expert opinions


  • •  Rejuvenates smoothness. Improves overall visible skin health and quality.
  • •  Minimizes the look of fine lines, wrinkles, pores, and skin pigmentation and discolorations.
  • •  Promotes radiance and revives the skin’s natural moisture for an ultimate glow.
  • •  Brightens the overall skin tone and clarity and enhances skin luminosity.
  • •  Renews the feeling of skin firmness, elasticity, and texture.
  • •  Helps improve the appearance of skin redness.
  • •  Promotes the skin barrier and immunity.


Why it’s different

  • •  Advanced targeted cosmetic treatment with an established and validated science. A unique mechanism of action.
  • •  Contains 5 times more defensin-molecules than any other formulas.
  • •  Light-weight application; “you don't feel it when you're wearing it”.
  • •  Effective and safe for the entire face, including the delicate skin around the eyes and lips, and the neck and décolleté. High-performing on the crepey thin skin on the neck and arms.
  • •  Fast acting anti-aging – first results are seen within a few weeks.
  • •  Perfect as a daily skincare product for both men and women.
  • •  Effective for both early and late stages of skin aging, including people above 70.
  • •  Non-irritating and gentle on sensitive skin overall, and over retinols.
  • •  Tolerated by all skin types. Good for rosacea and melasma patients, can be combined with other treatments for rosacea patients.
  • •  Highly effective for pre- and post- aesthetic procedures to achieve the optimal outcomes, including microneedling and fractional and resurfacing/ablative laser treatments. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.  
  • •  Effective to prep the skin and enhance filler results, recommended to use 4-6 weeks before a filler procedure.
  • •  DefenAge's most “likable” product with the most impressive consumer feedback.
  • •  Mega size, 1.5 fl oz, is now available.


Made in the U.S.A.



10 specific ways leading dermatologists recommend using the 8-in-1 BioSerum:


  1. For daily use. It’s lightweight. “You can’t even feel it when you’re wearing it.” Dermatologist Vivian Bucay, MD


  1. For sensitive skin. It delivers anti-aging results but it’s “not irritating like a retinol or acids.” Dermatologist Anne Chapas, MD


  1. For older age. Even old skin has young dormant cells that can be turned on by defensins. “We saw a marked difference at 2 months” in a 73-year-old patient. Dermatologist Angela Bowers, MD


  1. For better skin quality, including firmer skin, fewer fine lines, more luminosity and clarity, and a reduced appearance of pores. Dermatologist Anne Chapas, MD


  1. After microneedling, patients are “less likely to break out with acne post treatment.” Dermatologist Vivian Bucay, MD


  1. “4 to 6 weeks before having filler procedures” to prep the skin and enhance results. Dermatologist Kathleen Welsh, MD


  1. Before and after ablative skin treatments, which “primes skin to respond more quickly and robustly, healing faster.” Dermatologist Steven Swengel, MD


  1. To target specific areas, including around the eyes and lips. Dermatologist Angela Bowers, MD


  1. Beyond the face: on the neck and décolleté. Dermatologist Steven Swengel, MD


  1. For crepey thin skin on the neck and arms. Dermatologist Kathleen Welsh, MD



Add an Anti Aging Cream to Your Skincare Regimen

Dermatologists agree, if you do one nice thing for your skin this year - introduce it to defensin-molecules. Defensins can be incorporated into your existing skincare regimen and do not conflict or compete with other skincare. Whether it’s CHANEL or Clinique, incorporating DefenAge + Defensins can actually enhance the skincare you already know and love.


Consumer survey says that 93% of consumers who use CHANEL

skincare also like the results they see with DefenAge!

/ Survey 2019, data on file /


“Why do CHANEL users like DefenAge? – this is simple – DefenAge’s defensins multiply the effect of other skincare. …Ironically, DefenAge skin care has no competition on the skincare market because it enhances any other skin care brands. Much like laser treatments and microneedling, the topical application of defensins causes our body to message ‘preserved,’ healthy cells to create visibly new skin. I recommend the BioSerum to my patients to activate their “skin’s memory”, triggering skin to look younger, twice a day – in the morning and evening by applying just one drop of DefenAge BioSerum over the moisturizer of their choice,”

-Board-certified dermatologist Natalie M. Curcio, M.D., M.P.H.


Check with us, what other skincare than CHANEL can be combined with DefenAge's defensins for more glowing skin.  




Opinions and Stories


Healthy, Simple, and Safe Skincare Routines with Defensins from Supermodel Veronica Webb

by Veronica Webb, supermodel mom and influencer

Aging powerfully is as much about your attitude as it is about the skincare products you use. Veronica Webb, supermodel, mom, influencer, and beauty writer talks dermatologist recommended anti-aging clean beauty serums, moisturizers, and cleansers. Veronica shares her take simple safe and healthy confidence-boosting skincare routines that make a daily difference. Read more ...


How Effective Is Combining Products From Different Skincare Lines?

by Eliza Cabana, aesthetic and skin rejuvenation guru

Don’t want to give up your Chanel (or other) skincare product for something new? With DefenAge, you don’t have to! One expert explains how you can combine your favorite products with the DefenAge line to get all the benefits of both. Read more ...


The Secret to Effective 'Anti-Aging'

by Eliza Cabana, aesthetic and skin rejuvenation guru

Who doesn’t love a good anti-aging cream? But will it actually turn back the clock for your skin? One expert shares her perspective on the “anti-aging” misnomer as well as tips for what steps you can take to get the most out of your skincare routine. Read more...


Introduce Your Skin to the Benefits of DefenAge’s 8-in-1 BioSerum This Year

DefenAge’s 8-in-1 BioSerum may be lightweight, but it packs more Defensin molecules than any of DefenAge’s other products. Age-Repair Defensins wake up dormant cells to make brand-new, healthy cells. The result is skin that looks brighter, smoother, and firmer. If you don’t want to use retinol, try the dermatologist recommended skin care from DefenAge, including 8-in-1 BioSerum. Age-Repair Defensins are just as effective as retinol. Read more...


How to Get the Best Results From Your Anti-Aging Skin Care Products

The best anti aging skin care products will help your skin look brighter, smoother, plumper, and reduce the appearance of wrinkles. But if you want to truly maximize the product’s effectiveness, there are several things to keep in mind. Using skin care products that address signs of aging is a commitment, but it’s worth it when you start seeing results. Read more...


DefenAge’s Anti-Aging Serum: A Spring Skin Care Must-Have

The 8-in-1 BioSerum, anti-aging serum, from DefenAge is a best-selling product with the highest concentration of Age-Repair Defensins. Defensins are molecules that prompt dormant cells to make brand-new, healthy skin cells. DefenAge is the only brand to use Age-Repair Defensins, a proprietary ingredient. The result is new skin cells that look younger and healthier. DefenAge’s products don’t merely cover signs of visible aging.



8-in-1 BioSerum - Mega Size

STEP THREE | 8-in-1 BioSerum 

Daily: AM | PM

Place 1 pump of 8-in-1 BioSerum (bio serum) onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.

Suitable for all skin types.





For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 7 clinical studies.



The 8-in-1 BioSerum | Concept Anti Aging Cream was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.

Additional opthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.

The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.

All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.

We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile.  

Concept Ant-Aging Cream | 8-in-1 BioSerum




Age-Repair Defensins® | 5X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.

Hyaluronic Acid | Low Molecular Weight

• hydration •

Promotes hydration and improves texture for remarkably smooth and even skin.

Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Natural Antioxidants, Enzymes

and Hydrating Technologies

antioxidants • hydration • soothing

Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.


The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excused from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.



The bottle, box and package components are fully recyclable, please recycle.

We do not test products on animals.


8-in-1 BioSerum | Concept Anti Aging Cream

Water (Aqua), Cyclopentasiloxane, Glycerin, Niacinamide, Sinorhizobium Meliloti Ferment Filtrate, Dimethicone, Polysorbate 20, Dimethicone/Vinyl Dimethicone Crosspolymer, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phospholipids, Alpha-Defensin 5, Beta-Defensin 3, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Arabidopsis Thaliana Extract, Sea Whip Extract, Ergothioneine, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Offinalis (Rosemary) Leaf Extract, Tocopheryl Acetate, Ubiquinone, Leuconostoc/Radish Root Ferment Filtrate, Albumin, L-Alanyl-L-Glutamine, Caprylic/Capric Triglyceride, Cetyl Hydroxyethylcellulose, Lecithin, Hydroxypropyl Cyclodextrin, Phytic Acid, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Sodium Chloride.
Fragrance free.

This product does not contain retinol and should not be considered as a retinol serum.



Quality guaranteed ONLY when 8-in-1 BioSerum is sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



8-in-1 BioSerum | Concept Anti Aging Cream (bio serum) is qualified for the Money Back Guarantee.
Return Policy ►


What makes this serum effective for anti-aging and rejuvenation?
The effectiveness of our 8-in-1 BioSerum in anti-aging and rejuvenation stems from its unique blend of potent ingredients and advanced technology. Central to its formula is the Age-Repair Defensin® Complex, which contains defensin molecules. These bio-synthesized molecules are key to the serum’s effectiveness as they tap into skin's natural regenerative processes. Here's how the serum works to combat aging and visibly rejuvenate your skin: Comprehensive Formulation: Unlike traditional serums, our 8-in-1 BioSerum combines the benefits of eight specialized serums in one. Each 'serum' within targets specific aging concerns, from hydration to collagen boosting, offering a complete anti-aging solution. Advanced Defensin Technology: The serum's high concentration of Alpha-Defensin 5 and Beta-Defensin 3, exclusive to DefenAge, actively help to rejuvenate skin by promoting new, younger-looking skin and enhancing skin's natural barrier. These molecules are recognized as a safe and effective alternative to retinol, making the serum suitable for even sensitive skin types. Multi-Dimensional Benefits: The 8-in-1 BioSerum addresses various visible signs of aging – it smoothens fine lines and wrinkles, improves skin texture, boosts hydration, enhances firmness, and provides potent antioxidant protection. This comprehensive approach ensures visible rejuvenation of the skin. Proven Results: Supported by dermatologists and aesthetic professionals, our serum is not just a product but a scientifically-backed solution. Its efficacy in anti-aging and visible skin rejuvenation has been proven through rigorous clinical studies and real-world use. By integrating these advanced components and science-backed ingredients, the 8-in-1 BioSerum stands out as a highly effective product for both anti-aging and visible skin rejuvenation, delivering noticeable results that are both rapid and long-lasting.