The BEST Neck Cream Award | NewBeauty Neck Cream Award | People


“The often-neglected area gets some serious TLC from DefenAge 6-Week Perfection Neck Cream, an intense, treatment-like cream that has the ability to strengthen fragile skin on the neck," - states Santa Monica, CA dermatologist Ava Shamban, M.D., in the Award inaugural article.

Neck-Tightening Cream Description

The DefenAge 6-Week Perfection Neck Tightening Cream is a luxe anti-aging neck-firming cream formulated using leading scientific advances. It has become the best neck-firming cream in the industry for its ability to correct the challenging deep lines, folds, and impacts of gravity on the fragile skin of the neck, where aging is often more noticeable. Expert opinions

  • •  As one of the few neck creams that work, it reverses a comprehensive range of neck-specific visible signs of skin aging; designed to produce treatment-like results.
  • •  This neck-firming formula soothes the look of deep lines and folds and visibly reduces fine lines. It gives the neck a smooth appearance, making it the best cream for neck wrinkles.
  • •  The firming cream visibly lifts, firms, and tightens sagging neck skin.
  • •  Our skin-tightening cream for the neck brightens your complexion and improves visible skin thickness.
  • •  It softens and improves the surface skin texture.
  • •  Use this firming neck cream for ultra-rich moisturization.
  • •  It will always leave the neck looking and feeling youthful.

Why Our Neck-Firming Cream Is Different

  • •  This neck-firming cream is designed for the neck's skin, which ages differently than other parts of our skin.
  • •  Neck-tightening cream is ideal for both early and late stages of neck aging.
  • •  This fast-acting neck-tightening cream delivers the first results within two weeks and the full range of effects in six weeks.
  • •  It’s gentle on the sensitive neck skin over retinol.
  • •  As the best neck cream for wrinkles, it has a scientifically validated, high-performing formula.
  • •  DefenAge exceeds clean beauty standards. No PEGs or animal- or human-derived ingredients are found in our products. Our skincare line is also fragrance-free.
  • •  This neck-firming cream offers a silky application and smooth, luxurious texture. It spreads evenly without a “sticky” feeling.
  • •  Mega size: 1.5 oz

Made in the U.S.A.

Add These to Your Neck TIghtening Cream Routine:

Opinions and Stories

It’s all about the neck.

by Veronica Webb, supermodel mom, and influencer

Runway model, featured magazine cover star, and the first African-American to earn major cosmetics contracts, Veronica Webb shares her insights for picture-perfect skin. Read more ...

Correct the Look of Challenging Deep Lines with DefenAge’s Neck Tightening Cream

The 6-Week Perfection Neck Tightening Cream from DefenAge is formulated to target the skin on your neck. Neck-specific signs of aging, such as deep lines and folds, may seem challenging to combat or keep at bay. However, DefenAge’s firming neck cream is scientifically validated to offer results. The powerful formula supports the visible texture of your skin using DefenAge’s propriety Age-Repair Defensins technology. You can target the delicate skin on your neck using this luxurious DefenAge formula and support the appearance of youthful-looking skin.



Neck Tightening Cream | 6-WEEK PERFECTION NECK CREAM by DefenAge

STEP TWO - NECK| 6-Week Perfection Neck Cream 

Daily: AM | PM

Twice daily after cleansing, place 1 pump of the neck tightening cream onto fingertips. While skin is still moist, lightly massage cream onto the skin with short lifting motions using fingers of right hand to apply to left side of neck and décolleté, and vice versa. Start above breast line and work up to jawline and back of neck. Wait 30 seconds, then apply 8-in-1 BioSerum | STEP THREE.

Suitable for all skin types.




For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.


The 6-Week Perfection Neck Cream is dermatologist tested.


It is a valuable addition to the DefenAge line to treat the fragile skin of the neck, which can typically get irritated from standard anti-aging creams like retinol. Using the advanced technology they have pioneered, the new neck cream can bring brightness, improve the visible thickness of the skin, and reduce the wrinkling on the neck where aging is often more noticeable,

- Dermatologist Amy Forman Taub, MD


“My favorite neck cream is the new 6-Week Perfection Neck Cream. Scientifically proven defensin molecules result in skin looks firmer, smoother, and more even toned."

- Dermatologist Vivian Bucay, MD


“Many neck creams have proprietary peptides addressing early laxity but with different ingredients. The combo of defensins, as well as peptides, in this product can be a game changer; the defensins’ entire impact on the epidermis is more than peptides alone. An increase in blood supply and dermal support to a more robust epidermis can be critical. A lot of early neck changes start with the epidermis and superficial dermis. I also recommend adding an extra pump of DefenAge’s 8-in-1 BioSerum to apply on the neck to my patients like I do with my own skin care regimen,"

- Dermatologist Steven Swengel, MD


“I have tried the DefenAge anti-aging neck cream twice a day for one week and love it. The texture is smooth, so it spreads easily and evenly. I love that it is very hydrating and it seems to immediately reduce visible fine lines, giving the neck a smooth appearance,”

- Dermatologist Melda Isaac, MD


“After just 11 days of my patients using the neck cream, I was impressed to see the softening of lines and skin texture, and a visible tightening effect,"

- Clinical Professor of Surgery at UCLA, Gregory Keller, MD


“The 6-Week Perfection Neck Cream has a very luxurious texture and is a superb moisturizer, and an excellent addition to the DefenAge product range that I recommend to my patients. They can also use it on their hands and arms,”

- Dermatologist Angela Bowers, MD


DefenAge does it again! Another great product harnessing their defensin technology. I’m excited to be able to add this new innovation to my portfolio and recommend DefenAge’s neck cream to my patients.

- Dermatologist Sue Ellen Cox, MD


“Finally, the neck cream we have all been waiting for, loaded with the defensin technology we know gives visible results that last. This light but luxurious-feeling cream is hydrating without the sticky feeling often associated with other neck creams. It goes on smoothly, leaving my neck looking and feeling more youthful,”

- Linda Pitt, Master Aesthetician, Signature Medical Spa


Source: Neck Tightening Cream Article | Modern Aesthetics Magazine ►



Age-Repair Defensins® | 1X  | DefenAge's Exclusive

promotes new skin • anti-aging on a global scale • retinol alternative

Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.


hydration • firmness & elasticity • brightening

Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone.


Sea Whip

• skin calming & soothing •

Keeps skin calm. Strongest, fastest, most effective soothing ingredient from the sea.

Fine Blends of Advanced Peptides and Natural Extracts

anti-wrinkle • hydration • visible tightening

Our “know-how”-protected, advanced, and powerful blends of peptides and natural extracts have been shown to be effective in visible tightening of sagging neck skin.



• skin-replenishing •

Energize skin hydration. One of nature’s most powerful retainers of moisturization.


Vitamin E

• antioxidant •

Proven antioxidant, address environmental cell damage and defend against free radicals. Clarify and energize the skin for a revitalized radiance and luminosity.



The neck cream formula exceeds most, if not all, industry and beauty standards for clean skincare. In addition to the extended list of ingredients that are restricted for use in DefenAge, the 6-Week Perfection Neck Tightening Cream also does not contain silicones, PEGs, and is free from fragrance. To learn more about DefenAge’s clean skincare standards, please visit our Clean Beauty page.


The jar-bottle and box are fully recyclable, please recycle.

Not tested on animals.


6-Week Perfection Neck Cream

Water (Aqua), Butyrospermum Parkii (Shea) Butter, C13-15 Alkane, Caprylic / Capric Triglyceride, Propanediol, Niacinamide, Glycerin, Cetyl Alcohol, Phospholipids, Alpha-Defensin 5 (sh-Oligopeptide-109 SP), Beta-Defensin 3 (sh-Oligopeptide-108 SP), Stearyl Alcohol, Simmondsia Chinensis (Jojoba) Seed Oil, Squalane, Leontopodium Alpinum Callus Culture Extract, Palmitol Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sea Whip Extract, Ubiquinone, Tocopheryl Acetate, Panthenol, Albumin, l-Alanyl-l-Glutamine, Palmitic Acid, Sodium Stearoyl Glutamate, Methyl Glucose Sesquistearate, Polysorbate 20, Polyacrylate Crosspolymer-6, Xanthan Gum, Butylene Glycol, Carbomer, Phytic Acid, Sodium Phytate, Leuconostoc/Radish Root Ferment Filtrate, Caprylhydroxamic Acid, 1,2-Hexanediol, Sorbic Acid, Sodium Chloride.



Quality guaranteed ONLY when 6-Week Perfection Neck Cream is sold by defenage.com or authorized professionals, otherwise it may be counterfeit, black market, old or improperly stored or handled.
Quality is NOT guaranteed when sold by Amazon, eBay or other unauthorized sources. 



6-Week Perfection Neck Cream is qualified for the Money Back Guarantee.
Return Policy ►


Is neck cream important?
Even those who are diligent about their facial care often forget to take equally good care of the skin on their neck. Just as your face develops wrinkles over time, so too does your neck. As you age, you may start to develop sagging skin, vertical muscle bands, and unwanted fat deposits due to repetitive muscle movement and a decline in collagen production. Neck-firming cream is important to incorporate into your skincare routine to lift the skin of the neck and make it appear tighter and firmer.
When should you start using neck cream for wrinkles?
It is recommended that you start using neck-tightening cream from your early 30s onward. Even if you don’t see signs of aging at this point in life, skin-tightening cream for the neck is a great preventative measure to help delay the onset of wrinkles and sagging skin that tends to appear in a person’s late 30s and early 40s.
Do neck-tightening creams really work?
Although there’s a lot of false advertising out there, there are in fact, some neck creams that work — especially when you use them correctly and consistently. Our award-winning 6-Week Neck Tightening Cream is one of the few neck creams that work and has become the best neck-firming cream in the industry. It is infused with Age-Repair Defensins®, brightening niaciniamide, calming seawhip, a fine blend of natural antioxidants, enzymes, and hydrating technologies that help visibly lift, firm, and tighten sagging neck skin.
Is retinol good for neck wrinkles?
Although retinol can be helpful in treating neck wrinkles, a lot of people experience sensitivity to it. With the neck having thinner skin than other areas of the body, the probability for a negative reaction increases. We recommend seeking retinol alternatives that are formulated specifically for use on the neck. Our 6-Week Neck Tightening Cream is infused with Age-Repair Defensins® which are more gentle on the sensitive neck skin over retinol. It has also been specifically designed for the neck's skin, which ages differently than other parts of our skin.
Can you reverse neck wrinkles?
While extreme cases may require dermatological intervention via injections or surgical procedures, early wrinkles can be treated at home with specially formulated skin care products. Skincare science has proven time and time again that wrinkles can be diminished with help from the consistent proper use of the best neck-firming creams.
At what age does turkey neck start?
Most people notice neck skin beginning to sag and wrinkle in their late 30's or early 40's. “Turkey neck” occurs when the neck muscles start to weaken, and your skin elasticity dissipates, losing its capability to stretch and tighten.
Can neck skin be tightened naturally?
Nonsurgical, minimally invasive procedures aren't as dramatic as surgical treatments. They can, however, help improve skin tone and texture, reduce the appearance of wrinkles and neck folds, and give the contour of your neck a more youthful look. Getting a hot massage can help in repairing wrinkles and dryness, as well as replenishing the skin. Nourishing your body with a well-balanced diet can help improve your skin including drinking water which is one of the most effective ways to keep your skin tight. Drinking more mineral water can help as well! Maintaining a healthy weight as well as having a regular exercise regimen can help with the skin's elasticity.
How do dermatologists tighten neck skin?
There are multiple procedures and treatments that dermatologists recommend to tighten neck skin, including laser treatments, radiofrequency, micro-needling, chemical peels, and more. Even if you have a procedure done such as micro-needling, you still want to use an effective neck cream afterwards to maintain the results. Furthermore, with its scientifically-advanced formula infused with Age-Repair Defensins®, our 6-Week Neck Tightening Cream is designed to produce treatment-like results.
What to look for when shopping for the best neck cream.
The skin on the neck is fragile and can be thinner and more sensitive than the skin on your face so we need to treat that area with extra care. Try to look for products that contain ingredients that help protect your skin from elements like the sun and pollution. Moisturizing ingredients are a must! Look out for products that keep the skin hydrated that also contain anti-aging peptides. Fragrances might be harsher in this area so try to find fragrance-free products and be sure to find a cream that is animal-cruelty free as well.
Why trust DefenAge?
We started DefenAge to care for your skin’s deepest needs and share our cutting-edge anti -aging skincare system. Clean skincare is our philosophy and we pride ourselves on making products that are safe and free from animal and human derived ingredients. Our promise is to ensure we meet the highest standards in every way.